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Structural Basis of Antibody Protection Against West Nile Virus

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West Nile Encephalitis Virus Infection

Part of the book series: Emerging Infectious Diseases of the 21 Century ((EIDC))

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Abstract

The structural basis for antibody-mediated neutralization of West Nile virus infection has been investigated by a variety of biophysical and biochemical approaches that have begun to reveal the underlying mechanisms involved in this process. Crystallographic studies of E protein complexed with neutralizing monoclonal antibody Fab fragments have provided detailed information about the residues that are key to the process of antibody–epitope interaction. These studies have been mated to lower resolution cryo-electron microscopy studies that provide structures of bound Fab fragment to native flavivirus virions. The results suggest that antibody-mediated virus neutralization occurs in several different ways that impact the ability of the virus to go forward in its life cycle. Furthermore, these studies have highlighted the dynamic processes that flaviviruses undergo as part of their life cycle. Collectively, these studies suggest new approaches to the design of next generation flavivirus vaccines.

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Authors and Affiliations

  1. Department of Biological Sciences Markey Center for Structural Biology Purdue University West Lafayette, IN, USA

    Richard J. Kuhn

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  1. Richard J. Kuhn
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Kuhn, R.J. (2009). Structural Basis of Antibody Protection Against West Nile Virus. In: West Nile Encephalitis Virus Infection. Emerging Infectious Diseases of the 21st Century. Springer, New York, NY. https://doi.org/10.1007/978-0-387-79840-0_11

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