THE ROLE OF PI3K SIGNALLING IN THE B CELL RESPONSE TO ANTIGEN

  • Daniel J. Hodson
  • Martin Turner
Chapter

References

  1. 1.
    Anderson, K.E., Coadwell, J., Stephens, L.R. Hawkins, P.T. (1998) Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B. Curr Biol, 8, 684–691CrossRefGoogle Scholar
  2. 2.
    Anzelon, A.N., Wu, H. Rickert, R.C. (2003) Pten inactivation alters peripheral B lymphocyte fate and reconstitutes CD19 function. Nat Immunol, 4, 287–294CrossRefGoogle Scholar
  3. 3.
    Bi, L., Okabe, I., Bernard, D.J. Nussbaum, R.L. (2002) Early embryonic lethality in mice deficient in the p110beta catalytic subunit of PI 3-kinase. Mamm Genome, 13, 169–172Google Scholar
  4. 4.
    Bi, L., Okabe, I., Bernard, D.J., Wynshaw-Boris, A. Nussbaum, R.L. (1999) Proliferative defect and embryonic lethality in mice homozygous for a deletion in the p110alpha subunit of phosphoinositide 3-kinase. J Biol Chem, 274, 10963–10968CrossRefGoogle Scholar
  5. 5.
    Bilancio, A., Okkenhaug, K., Camps, M., Emery, J.L., Ruckle, T., Rommel, C. Vanhaesebroeck, B. (2006) Key role of the p110delta isoform of PI3K in B-cell antigen and IL-4 receptor signaling: comparative analysis of genetic and pharmacologic interference with p110delta function in B cells. Blood, 107, 642–650CrossRefGoogle Scholar
  6. 6.
    Chantry, D., Vojtek, A., Kashishian, A., Holtzman, D.A., Wood, C., Gray, P.W., Cooper, J.A. Hoekstra, M.F. (1997) p110delta, a novel phosphatidylinositol 3-kinase catalytic subunit that associates with p85 and is expressed predominantly in leukocytes. J Biol Chem, 272, 19236–19241CrossRefGoogle Scholar
  7. 7.
    Clayton, E., Bardi, G., Bell, S.E., Chantry, D., Downes, C.P., Gray, A., Humphries, L.A., Rawlings, D., Reynolds, H., Vigorito, E. Turner, M. (2002) A crucial role for the p110delta subunit of phosphatidylinositol 3-kinase in B cell development and activation. J Exp Med, 196, 753–763CrossRefGoogle Scholar
  8. 8.
    Cozine, C.L., Wolniak, K.L. Waldschmidt, T.J. (2005) The primary germinal center response in mice. Curr Opin Immunol, 17, 298–302CrossRefGoogle Scholar
  9. 9.
    Del Nagro, C.J., Otero, D.C., Anzelon, A.N., Omori, S.A., Kolla, R.V. Rickert, R.C. (2005) CD19 function in central and peripheral B-cell development. Immunol Res, 31, 119–131CrossRefGoogle Scholar
  10. 10.
    Di Cristofano, A., Pesce, B., Cordon-Cardo, C. Pandolfi, P.P. (1998) Pten is essential for embryonic development and tumour suppression. Nat Genet, 19, 348–355CrossRefGoogle Scholar
  11. 11.
    Eickholt, B.J., Ahmed, A.I., Davies, M., Papakonstanti, E.A., Pearce, W., Starkey, M.L., Bilancio, A., Need, A.C., Smith, A.J., Hall, S.M., Hamers, F.P., Giese, K.P., Bradbury, E.J. Vanhaesebroeck, B. (2007) Control of axonal growth and regeneration of sensory neurons by the p110delta PI 3-kinase. PLoS ONE, 2, e869CrossRefGoogle Scholar
  12. 12.
    Fruman, D.A. (2004) Phosphoinositide 3-kinase and its targets in B-cell and T-cell signaling. Curr Opin Immunol, 16, 314–320CrossRefGoogle Scholar
  13. 13.
    Fruman, D.A., Snapper, S.B., Yballe, C.M., Davidson, L., Yu, J.Y., Alt, F.W. Cantley, L.C. (1999) Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85alpha. Science, 283, 393–397CrossRefGoogle Scholar
  14. 14.
    Hawkins, P.T., Anderson, K.E., Davidson, K. Stephens, L.R. (2006) Signalling through class I PI3Ks in mammalian cells. Biochem Soc Trans, 34, 647–662CrossRefGoogle Scholar
  15. 15.
    Hirsch, E., Katanaev, V.L., Garlanda, C., Azzolino, O., Pirola, L., Silengo, L., Sozzani, S., Mantovani, A., Altruda, F. Wymann, M.P. (2000) Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation. Science, 287, 1049–1053CrossRefGoogle Scholar
  16. 16.
    Jou, S.T., Carpino, N., Takahashi, Y., Piekorz, R., Chao, J.R., Carpino, N., Wang, D. Ihle, J.N. (2002) Essential, nonredundant role for the phosphoinositide 3-kinase p110delta in signaling by the B-cell receptor complex. Mol Cell Biol, 22, 8580–8591CrossRefGoogle Scholar
  17. 17.
    Maehama, T. Dixon, J.E. (1998) The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem, 273, 13375–13378CrossRefGoogle Scholar
  18. 18.
    Muto, A., Tashiro, S., Nakajima, O., Hoshino, H., Takahashi, S., Sakoda, E., Ikebe, D., Yamamoto, M. Igarashi, K. (2004) The transcriptional programme of antibody class switching involves the repressor Bach2. Nature, 429, 566–571CrossRefGoogle Scholar
  19. 19.
    Ochiai, K., Katoh, Y., Ikura, T., Hoshikawa, Y., Noda, T., Karasuyama, H., Tashiro, S., Muto, A. Igarashi, K. (2006) Plasmacytic transcription factor Blimp-1 is repressed by Bach2 in B cells. J Biol Chem, 281, 38226–38234CrossRefGoogle Scholar
  20. 20.
    Okada, T., Maeda, A., Iwamatsu, A., Gotoh, K. Kurosaki, T. (2000) BCAP: the tyrosine kinase substrate that connects B cell receptor to phosphoinositide 3-kinase activation. Immunity, 13, 817–827CrossRefGoogle Scholar
  21. 21.
    Okkenhaug, K., Bilancio, A., Farjot, G., Priddle, H., Sancho, S., Peskett, E., Pearce, W., Meek, S.E., Salpekar, A., Waterfield, M.D., Smith, A.J. Vanhaesebroeck, B. (2002) Impaired B and T cell antigen receptor signaling in p110delta PI 3-kinase mutant mice. Science, 297, 1031–1034Google Scholar
  22. 22.
    Okkenhaug, K. Vanhaesebroeck, B. (2003) PI3K in lymphocyte development, differentiation and activation. Nat Rev Immunol, 3, 317–330CrossRefGoogle Scholar
  23. 23.
    Oliver, A.M., Martin, F., Gartland, G.L., Carter, R.H. Kearney, J.F. (1997) Marginal zone B cells exhibit unique activation, proliferative and immunoglobulin secretory responses. Eur J Immunol, 27, 2366–2374CrossRefGoogle Scholar
  24. 24.
    Omori, S.A., Cato, M.H., Anzelon-Mills, A., Puri, K.D., Shapiro-Shelef, M., Calame, K. Rickert, R.C. (2006) Regulation of class-switch recombination and plasma cell differentiation by phosphatidylinositol 3-kinase signaling. Immunity, 25, 545–557CrossRefGoogle Scholar
  25. 25.
    Omori, S.A. Rickert, R.C. (2007) Phosphatidylinositol 3-kinase (PI3K) signaling and regulation of the antibody response. Cell Cycle, 6, 397–402Google Scholar
  26. 26.
    Petersen, S., Casellas, R., Reina-San-Martin, B., Chen, H.T., Difilippantonio, M.J., Wilson, P.C., Hanitsch, L., Celeste, A., Muramatsu, M., Pilch, D.R., Redon, C., Ried, T., Bonner, W.M., Honjo, T., Nussenzweig, M.C. Nussenzweig, A. (2001) AID is required to initiate Nbs1/gamma-H2AX focus formation and mutations at sites of class switching. Nature, 414, 660–665CrossRefGoogle Scholar
  27. 27.
    Phan, T.G., Paus, D., Chan, T.D., Turner, M.L., Nutt, S.L., Basten, A. Brink, R. (2006) High affinity germinal center B cells are actively selected into the plasma cell compartment. J Exp Med, 203, 2419–2424CrossRefGoogle Scholar
  28. 28.
    Scheid, M. (2002) PIP3 is essential but not sufficient for protein kinase B activation; PIP2 is required for PKB phosphorylation at ser-473. J Biol Chem, 277, 9027–9035CrossRefGoogle Scholar
  29. 29.
    Shapiro-Shelef, M. Calame, K. (2005) Regulation of plasma-cell development. Nat Rev Immunol, 5, 230–242CrossRefGoogle Scholar
  30. 30.
    Shen, W.H., Balajee, A.S., Wang, J., Wu, H., Eng, C., Pandolfi, P.P. Yin, Y. (2007) Essential role for nuclear PTEN in maintaining chromosomal integrity. Cell, 128, 157–170CrossRefGoogle Scholar
  31. 31.
    Suzuki, A., Pompa, J.L., de la Stambolic, V., Elia, A.J., Sasaki, T., Barco Barrantes, I., del Ho, A., Wakeham, A., Itie, A., Khoo, W., Fukumoto, M. Mak, T.W. (1998) High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice. Curr Biol, 8, 1169–1178CrossRefGoogle Scholar
  32. 32.
    Suzuki, A., Kaisho, T., Ohishi, M., Tsukio-Yamaguchi, M., Tsubata, T., Koni, P.A., Sasaki, T., Mak, T.W. Nakano, T. (2003) Critical roles of Pten in B cell homeostasis and immunoglobulin class switch recombination. J Exp Med, 197, 657–667CrossRefGoogle Scholar
  33. 33.
    Suzuki, H., Terauchi, Y., Fujiwara, M., Aizawa, S., Yazaki, Y., Kadowaki, T. Koyasu, S. (1999) Xid-like immunodeficiency in mice with disruption of the p85alpha subunit of phosphoinositide 3-kinase. Science, 283, 390–392CrossRefGoogle Scholar
  34. 34.
    Vanhaesebroeck, B., Welham, M.J., Kotani, K., Stein, R., Warne, P.H., Zvelebil, M.J., Higashi, K., Volinia, S., Downward, J. Waterfield, M.D. (1997) P110delta, a novel phosphoinositide 3-kinase in leukocytes. Proc Natl Acad Sci USA, 94, 4330–4335CrossRefGoogle Scholar
  35. 35.
    Vigorito, E., Bardi, G., Glassford, J., Lam, E.W., Clayton, E. Turner, M. (2004) Vav-dependent and vav-independent phosphatidylinositol 3-kinase activation in murine B cells determined by the nature of the stimulus. J Immunol, 173, 3209–3214Google Scholar
  36. 36.
    Vigorito, E. Turner, M. (2006) Differential requirements of PI3K subunits for BCR or BCR/CD19-induced ERK activation. Adv Exp Med Biol, 584, 43–52CrossRefGoogle Scholar
  37. 37.
    Yamazaki, T., Takeda, K., Gotoh, K., Takeshima, H., Akira, S. Kurosaki, T. (2002) Essential immunoregulatory role for BCAP in B cell development and function. J Exp Med, 195, 535–545CrossRefGoogle Scholar
  38. 38.
    Yoshida, C., Yoshida, F., Sears, D.E., Hart, S.M., Ikebe, D., Muto, A., Basu, S., Igarashi, K. Melo, J.V. (2007) Bcr-Abl signaling through the PI-3/S6 kinase pathway inhibits nuclear translocation of the transcription factor Bach2, which represses the antiapoptotic factor heme oxygenase-1. Blood, 109, 1211–1219CrossRefGoogle Scholar
  39. 39.
    Janas M, Hodson D et al. The effect of deleting p110delta on the phenotype and function of PTEN-deficient B cells. J. Immunol. 2008 Jan 15;180(2):739–46.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Daniel J. Hodson
    • 1
  • Martin Turner
  1. 1.Laboratory of Lymphocyte Signalling and DevelopmentBabraham InstituteCambridge CB22 2AT

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