• Daniel J. Hodson
  • Martin Turner
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 633)

1 Introduction

The PI3K signal transduction pathway is employed by a wide variety of cells in organisms from yeasts to humans to regulate biological processes such as growth, metabolism and survival. In B cells the PI3K signalling pathway is activated downstream of the B cell receptor where, in contrast to cells outside the immune system, signalling appears particularly dependent upon the PI3K catalytic subunit known as p110δ. BCR-induced PI3K activity is believed to play an important role in the regulation of both B cell development and the B cell response to antigen. Although we have learned much from the use of gene-targeted mice several areas of uncertainty still exist. Our current knowledge of the role of PI3K signalling in the B cell antigen response will be discussed.

2 Background to the PI3K Signal Transduction Pathway

The phosphoinositide-3-kinases (PI3Ks) are a highly conserved family of lipid kinases that phosphorylate the 3′-hydroxyl group of phosphoinositide membrane...


Germinal Centre Marginal Zone PI3K Pathway Pleckstrin Homology PI3K Signalling 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



We thank our colleagues for many stimulating discussions. DJH is a Cancer Research UK McElwain Clinical Research Training Fellow and MT is a Senior Non-Clinical Fellow of the Medical Research Council. Both are additionally supported by the Biotechnology and Biological Sciences Research Council.


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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Daniel J. Hodson
    • 1
  • Martin Turner
  1. 1.Laboratory of Lymphocyte Signalling and DevelopmentBabraham InstituteCambridge CB22 2AT

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