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Cyclin Dependent Kinase 5 (Cdk5) pp 191–210Cite as

The Structural Bases of CDK5 Activity

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Abstract

In the last 15 years, a wealth of structural investigations on protein kinases has been reported. These studies have revealed that the active states of protein kinases are usually structurally alike, a requirement imposed by the necessity to maintain the basic geometry of a highly conserved machinery required for good catalytic output. Conversely, the structures of the inactive states of kinase-family members can vary widely from each other, a principle that can be exploited to improve the specificity of kinase inhibitors. In this chapter, we discuss the activation mechanism of the CDK5 kinase within the general frame of reference of kinase activation mechanisms, and in comparison to other members of the CDK family. We explain how CDK5, not unlike other kinases, has made its own capricious decisions to design an original activation mechanism and distinguish itself from CDK-family relatives.

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  1. Department of Experimental Oncology, European Institute of Oncology, Via Adamello 16, I-20139, Milan, Italy

    Andrea Musacchio

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  1. Andrea Musacchio
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  1. Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China

    Nancy Y. Ip

  2. Department of Brain and Cognitive Science, Howard Hughes Medical Institute, Massachusetts Institute of Technology, 77 Massachusetts Avenue, 02139, Cambridge, MA, USA

    Li-Huei Tsai

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Musacchio, A. (2008). The Structural Bases of CDK5 Activity. In: Ip, N.Y., Tsai, LH. (eds) Cyclin Dependent Kinase 5 (Cdk5). Springer, Boston, MA. https://doi.org/10.1007/978-0-387-78887-6_14

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