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Safety of Nanoparticles pp 209–235Cite as

Nanoparticles for Cancer Diagnosis and Therapy

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Part of the book series: Nanostructure Science and Technology ((NST))

Abstract

Nanotechnology enables unique approaches to the diagnosis and treatment of cancer. Over the last two decades, a large number of nanoparticle-based cancer diagnostics and therapeutics have been developed. These include superparamagnetic iron oxide nanoparticles, gold nanoparticles, liposomes and polymeric nanoparticles. While some of the liposomal and polymer-based therapeutic nanoparticles have advanced to clinical applications, a greater number of remaining nanoparticles platforms are currently in the preclinical stages of development. They have relatively incomplete toxicity profiles at this time. In this chapter, we will review the available preclinical and clinical toxicity data of a variety of nanoparticle platforms.

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Acknowledgments

We thank Drs. Philip Kantoff and Neil Bander for helpful discussions throughout this study. This work was supported by National Institutes of Health Grants CA119349 and EB003647 and Koch–Prostate Cancer Foundation Award in Nanotherapeutics.

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Authors and Affiliations

  1. Laboratory of Nanomedicine and Biomaterials, Department of Anesthesia, Brigham and Women’s Hospital, Harvard Medical School, Boston, USA

    Andrew Z. Wang

  2. Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, USA

    Frank X. Gu

  3. MIT-Harvard Center for Cancer Nanotechnology Excellence, Massachusetts Institute of Technology, Cambridge, MA, USA

    Frank X. Gu & Omid C. Farokhzad

  4. Laboratory of Nanomedicine and Biomaterials, Department of Anesthesia, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA

    Omid C. Farokhzad

Authors
  1. Andrew Z. Wang
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  2. Frank X. Gu
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  3. Omid C. Farokhzad
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Corresponding author

Correspondence to Andrew Z. Wang .

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Editors and Affiliations

  1. School of Engineering, Brown University, 182 Hope Street, Providence, 02912, Rhode Island, USA

    Thomas J. Webster

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Wang, A.Z., Gu, F.X., Farokhzad, O.C. (2009). Nanoparticles for Cancer Diagnosis and Therapy. In: Webster, T. (eds) Safety of Nanoparticles. Nanostructure Science and Technology. Springer, New York, NY. https://doi.org/10.1007/978-0-387-78608-7_10

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