Skip to main content

Monoclonal Antibodies as Therapeutic Agents

  • Chapter
  • First Online:
Immunopharmacology
  • 856 Accesses

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 69.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 89.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Bibliography

  • Albanell J, Codony J, Rovira A, Mellado B, et al. 2003. Mechanism of action of anti-HER2 monoclonal antibodies: Scientific update on trastuzumab and 2C4. Adv Exp Med Biol. 532:253–268.

    PubMed  CAS  Google Scholar 

  • Baca M, Presta LG, O’Connor SJ, Wells JA. 1997. Antibody humanization using monovalent phage display. J Biol Chem. 272:10678–10684.

    PubMed  CAS  Google Scholar 

  • Bartelds GM, Wijbrandts CA, Nurmohamed MT, Stapel S, et al. 2007. Clinical response to adalimumab: Relationship to anti-adalimumab antibodies and serum adalimumab concentrations in rheumatoid arthritis. Ann Rheum Dis. 66:921–926.

    PubMed  CAS  Google Scholar 

  • Bennett JM, Kaminski MS, Leonard JP, Vase JM, et al. 2005. Assessment of treatment-related myelodysplastic syndromes and acute myeloid leukemia in patients with non-Hodgkin lymphoma treated with tositumomab and Iodine I 131 tositumomab. Blood. 1052: 4576–4582.

    Google Scholar 

  • Bielekova B, Richert N, Howard T, Blevins G, et al. 2004. Humanized anti-CD25 (daclizumab) inhibits disease activity in multiple sclerosis patients failing to respond to interferon beta. Proc Natl Acad Sci. 101:8705–8708.

    Google Scholar 

  • Binder M, Otto F, Mertelsmann R, Veelken H, et al. 2006. The epitope recognized by rituximab. Blood. 108:1975–1978.

    PubMed  CAS  Google Scholar 

  • Bonner JA, Harari PM, Giralt J, Azarmia N, et al. 2006. Radiotherapy plus centuximab for squamous-cell carcinoma of the head and neck. NEJM. 354:567–578.

    PubMed  CAS  Google Scholar 

  • Bordigoni P, Dimicoli S, Clement L, Baumann C. 2006. Daclizumab, an efficient treatment for steroid-refractory acute graft-versus-host disease. Br J Hematol. 135:382–385.

    CAS  Google Scholar 

  • Borro JM, De-la-Torre M, Miguelez C, Fernandez R, et al. 2005. Comparative study of basiliximab treatment in lung transplantation. Transplant Proc. 37:3996–3998.

    Google Scholar 

  • Boulianne GL, Hozumi N, Shulman MJ. 1984. Production of functional chimeric mouse/human antibody. Nature. 312:643–646.

    PubMed  CAS  Google Scholar 

  • Boyne J, Elter T, Engert A. 2003. An overview of the current clinical use of the anti-CD20 monoclonal antibody rituximab. 14:520–535.

    Google Scholar 

  • Braendstrup P, Bjerrum OW, Nielsen OJ, Jensen BA, et al. 2005. Rituximab chimeric anti-CD20 monoclonal antibody treatment for adult refractory idiopathic thrombocytopenic purpura. Am J Hematol. 78:275–280.

    PubMed  CAS  Google Scholar 

  • Brennan DC, Daller JA, Lake KD, Cibrik D. 2006. Rabbit antithymocyte globulin versus basiliximab in renal transplantation. NEJM. 355:1967–1977.

    PubMed  CAS  Google Scholar 

  • Bruggemann M, Witner G, Waldmann H, Neuberger MS. 1989. The immunogenicity of chimeric antibodies. J Exp Med. 170:2153–2157.

    PubMed  CAS  Google Scholar 

  • Burton C, Kaczmarski R, Jan-Mohamed R. 2003. Interstitial pneumonitis related to rituximab therapy. NEJM. 348:2690–2691.

    PubMed  Google Scholar 

  • Carter P, Presta L, Gorman CM, Ridgway JB, et al. 1992. Humanization of anti-p185HER2 antibody for human cancer therapy. Proc Natl Acad Sci USA. 89:4285–4289.

    Google Scholar 

  • Carter PJ. 2006. Potent antibody therapeutics by design. Nat Rev Immunol. 6:343–357.

    PubMed  CAS  Google Scholar 

  • Cartron G, Watier H, Golay J, Solal-Celigny P. 2004. From bench to the bedside: Ways to improve rituximab efficacy. Blood. 104:2635–2642.

    PubMed  CAS  Google Scholar 

  • Chothia C, Lesk AM, Tramontano A, Levitt M, et al. 1989. Conformations of immunoglobulin hypervariable regions. Nature. 342:877–883.

    PubMed  CAS  Google Scholar 

  • Choy EH, Pnaayi GS. 2001. Cytokine pathways and joint inflammation in rheumatoid arthritis. NEJM. 344:907–916.

    PubMed  CAS  Google Scholar 

  • Clark M. 2000. Antibody humanization: A case of the “emperor’s new clothes?” Immunol. Today. 21:397–402.

    CAS  Google Scholar 

  • Coiffier B, Lepage E, Briere J, Herbrecht R, et al. 2002. CHOP chemotherapy plus rituximab compared with CHOP alone in elderly patients with diffuse large-B-cell lymphoma. NEJM. 346:235–242.

    PubMed  CAS  Google Scholar 

  • Connors JM. 2005. Radioimmunotherapy – hot new treatment for lymphoma. NEJM. 352: 496–498.

    PubMed  CAS  Google Scholar 

  • Cosimi AB, Burton RD, Colvin RB, Goldstein G. 1981. Treatment of cute renal allograft rejection with OKT3 monoclonal antibody. Transplantation. 32:535–539.

    PubMed  CAS  Google Scholar 

  • Cunningham D, Humblet Y, ,Siena S, Khayat D, et al. 2004. Centuximab monotherapy and centuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer. NEJM. 351: 337–345.

    PubMed  CAS  Google Scholar 

  • Davies AJ, Rohatiner AZ, Howell S, Britton KE, et al. 2004. Tositumomab and Iodine I 131 tositumomab for recurrent indolent and transformed B cell non-Hodgkin’s lymphoma. J Clin Oncol. 22:1469–1479.

    PubMed  CAS  Google Scholar 

  • Davis TA, White CA, Grillo-Lopez AJ, Velasquez WS, et al. 1999. Single-agent monoclonal antibody efficacy in bulky non-Hodgkin’s lymphoma: Results of a phase II trial of Rituximab. J Clin Onc. 17:1851–1857.

    CAS  Google Scholar 

  • Dedrick RL, Walicke P, Garovoy M. 2002. Anti-adhesion antibodies efalizumab, a humanized anti-CD11a monoclonal antibody. Transplant Immunol. 9:181–186.

    CAS  Google Scholar 

  • Edwards J, Szczepanski L, Szechinski J, Filipowicz-Sosnowaska A, et al. 2004. Efficacy of B-cell-targeted therapy with rituximab in patients with rheumatoid arthritis. NEJM. 350:2572–2581.

    PubMed  CAS  Google Scholar 

  • Ettenger RB, Marik J, Rosenthal JT, Fine RN, et al. 1988. OKT3 for rejection reversal in pediatric renal transplantation. Clin Transplant. 2:180–184.

    Google Scholar 

  • Foote J, Winter G. 1992. Antibody framework residues affecting the conformation of the hypervariable loops. J Mol biol. 224:487–499.

    PubMed  CAS  Google Scholar 

  • Francis RJ, Sharma SK, Springer C, Green AJ, et al. 2002. A phase I trial of antibody directed enzyme prodrug therapy (ADEPT) in patients with advanced colorectal carcinoma or other CEA producing tumours. Br J Cancer. 87:600–607.

    PubMed  CAS  Google Scholar 

  • Gaston RS, Deierhoi MH, Patterson T, Prasthofer E, et al. 1991. OKT3 first-dose reaction: Association with T cell subsets and cytokine release. Kid Internat. 39:141–148.

    CAS  Google Scholar 

  • Goldberg RM. 2006. Therapy for metastatic colorectal cancer. The Oncologist. 11:981–987.

    PubMed  CAS  Google Scholar 

  • Goldman M, Abramowicz D, DePauw L, Alelgre M, et al. 1989. OKT3-induced cytokine released attenuation by high-dose methylprednisolone. Lancet. 2:802–803.

    PubMed  CAS  Google Scholar 

  • Goldstein G, Fuccello AJ, Norman DJ, Sheild CF, et al. 1986. OKT3 monoclonal antibody plasma levels during therapy and the subsequent development of host antibodies to OKT3. Transplantation. 42:507–511.

    PubMed  CAS  Google Scholar 

  • Goncalves LF, Ribeiro AR, Berdichevski R, Joelsons G. 2007. Basiliximab improves graft survival in renal transplant recipients with delayed graft function. Transplant Proc. 39:437–438.

    Google Scholar 

  • Graves JE, Nunley K, Heffernan MP. 2007. Off-label uses of biologics in dermatology: Rituximab, omalizumab, infliximab, etanercept, adalimumab, efalizumab and alefacept. J Am Acad Dermatol. 56:e55–e79.

    PubMed  Google Scholar 

  • Griggen JG. 2007. How I treat indolent lymphoma. Blood. 109:4617–4626.

    Google Scholar 

  • Hale G, Dyer MJS, Clark MR, Phillips JM, et al. 1988. Remission induction in non-Hodgkin lymphoma with reshaped human monoclonal antibody CAMPATH-1 H. Lancet. 2:1394–1399.

    PubMed  CAS  Google Scholar 

  • Hericourt J, Richet CH. 1895. de la serotherapie dans la traitement du cancer, Physologie Pathologique. 120:567–569.

    Google Scholar 

  • Hershberger RE, Randall SC, Eisen HJ, Bergh C-H, et al. 2005. Daclizumab to prevent rejection after cardiac transplantation. NEJM. 352:2705–2713.

    PubMed  CAS  Google Scholar 

  • Himmelweit F. 1960. The Collected Papers of Paul Erlich, Vol. 3,59, Pergmon, London.

    Google Scholar 

  • Hoogenboom HR. 2005. Selecting and screening recombinant antibody libraries. Nat Biotech. 23:1117–1125.

    Google Scholar 

  • Hooks MA, Wade CS, Millikan WJ. 1991. Muromonab CD-3: A review of its pharmacology, pharmacokinetics, and clinical use in transplantation. Pharmacotherapy. 11:26–37.

    PubMed  CAS  Google Scholar 

  • Hortobagyi GN. 2005. Trastuzumab in the treatment of breast cancer. NEJM. 353:1734–1736.

    PubMed  CAS  Google Scholar 

  • Hosenpud JD. 2005. Immunosuppression in cardiac transplantation. NEJM. 352:2749–2750.

    PubMed  CAS  Google Scholar 

  • Hudis CA. 2007. Trastuzumab-mechanism of action and use in clinical practice. NEJM. 357:39–51.

    PubMed  CAS  Google Scholar 

  • Hudson PJ, Souriau C. 1992. Engineered antibodies. Nat Med. 9:129–134.

    Google Scholar 

  • Hurwitz H, Fehrenbacher L, Novotny W, Cartwright T, et al. 2004. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. NEJM. 350:2335–2342.

    PubMed  CAS  Google Scholar 

  • Janeway C, Travers P, Walport M, Schlomchik M. 2001. Immunobiology, Fifth Edition, Garland Science, New York and London.

    Google Scholar 

  • Jazirehi AR, Bonavida B. 2005. Cellular and molecular signal transduction pathways modulated by rituximab (Rituxan, anti-CD20 mab) in non-Hodgkin’s lymphoma: Implications in characterization of therapeutic intervention. Oncogene. 24:2121–2143.

    PubMed  CAS  Google Scholar 

  • Jensen M, Klehr M, Vogel A, Schmitz S, et al. 2007. One step generation of fully chimeric antibodies using C gamma 1 and C kappa mutant mice. J Immunother. 30:338–349.

    PubMed  CAS  Google Scholar 

  • Jones PT, Dear PH, Foote J, Neuberger MS, et al. 1986. Replacing the complementarity-determining regions in a human antibody with those from a mouse. Nature. 321:522–525.

    PubMed  CAS  Google Scholar 

  • Kaminski MS, Tuck M, Estes J, Kolstad A, et al. 2005. 131I-Tositumomab therapy as initial treatment for follicular lymphoma. NEJM. 352:441–449.

    PubMed  CAS  Google Scholar 

  • Kapic E, Becic F, Kusturica J. 2004. Basiliximab, mechanism of action and pharmacological properties. Med Arch. 58:373–376.

    Google Scholar 

  • King DJ, Adair JR, Angal S, Low DC, et al. 1992. Expression, purification and characterization of a mouse-human chimeric antibody and chimeric Fab fragment. Biochem J. 281:317–323.

    PubMed  CAS  Google Scholar 

  • Knight DM, Trinh H, Le J, Siegel S, et al. 1993. Construction and initial characterization of a mouse-human chimeric anti-TNF antibody. Mol Immunol. 30:1443–1453.

    PubMed  CAS  Google Scholar 

  • Kohler G, Milstein C. 1975. Continuous culture of fused cells secreting antibody of predefined specificity. Nature. 256:495–497.

    PubMed  CAS  Google Scholar 

  • Krauss WC, park JW, Kirpotin DB, Hong K, Benz CC. 2002. Emerging antibody-based HER2 (ErbB-2/neu) therapeutics. Breast Dis. 11:113–124.

    Google Scholar 

  • Leahy MF, Seymour JF, Hicks RJ, Turner JH. 2006. Multicenter phase II clinical study of Iodine-131-Rituximab radiotherapy in relapsed or refractory indolent non-Hodgkin’s lymphoma. J Clin Oncol. 24:4418–4425.

    PubMed  CAS  Google Scholar 

  • Lind P, Lechner P, Hausmann B. 1991. Development of human anti-mouse antibodies (HAMA) after single and repeated diagnostic application of intact murine monoclonal antibodies. Antibody Immunoconjug Radiopharm. 4:811–818.

    Google Scholar 

  • Littlejohns P. 2006. Trastuzumab for early breast cancer: Evolution or revolution? Lancet Oncol. 7:22–23.

    PubMed  Google Scholar 

  • Lo-Coco F, Cimino G, Breccia M, Noguera NI, et al. 2004. Gemtuzumab ozogamicin (Mylotarg) as a single agent for molecularly relapsed acute promyelocytic leukemia. Blood. 104: 1995–1999.

    PubMed  CAS  Google Scholar 

  • Mascelli MA, Zhou H, Sweet R, Getsy J, et al. 2007. Molecular, biologic and pharmacokinetic properties of monoclonal antibodies: Impact of these parameters on early clinical development. J Clin Pharmacol. 47:553–565.

    PubMed  CAS  Google Scholar 

  • McArthur HL, Chia S. 2007. Cardiotoxicity of trastuzumab in clinical practice. NEJM. 357:94–95.

    PubMed  CAS  Google Scholar 

  • McCune SL, Gockerman JP, Rizzieri DA. 2001. Monoclonal antibody therapy in the treatment of non-Hodgkin’s lymphoma. JAMA. 286:1149–1152.

    PubMed  CAS  Google Scholar 

  • McLaughlin P, Grillo-Lopez AJ, Link BK, Levy R, et al. 1998. Rituximab chimeric anti-CD20 monoclonal antibody therapy for relapsed indolent lymphoma: Half of patients respond to a four-dose treatment program. J Clin Oncol. 16:2825–2833.

    PubMed  CAS  Google Scholar 

  • Menter A, Leonardi CL, Sterry W, Bos JD. 2006. Long-term management of plaque psoriasis with continuous efalizumab therapy. J Am Acad Dermatol. 54:S182–S188.

    PubMed  Google Scholar 

  • Morris JA, Hanson JE, Steffen BJ, Chu AH, et al. 2005. Daclizumab is associated with decreased rejection and improved patient survival in renal transplant patients. Clin Transplant. 19:340–345.

    PubMed  CAS  Google Scholar 

  • Morrison SL, Johnson MJ, Herzenberg LA, Oi VT. 1984. Chimeric human antibody molecules: Mouse antigen binding domains with human constant region domains. Proc Natl Acad Sci USA. 81:6851–6855.

    Google Scholar 

  • Nadler LM, Stashenko P, Hardy R, Kaplan WB, et al. 1980. Serotherapy of a patient with a monoclonal antibody directed against a human lymphoma associated antigen. Cancer Res. 40:3147–3154.

    PubMed  CAS  Google Scholar 

  • O’Dell JR. 2004. Therapeutic strategies for rheumatoid arthritis. NEJM. 350:2591–2602.

    PubMed  Google Scholar 

  • Okamoto H. 2006. Effect of rituximab in refractory SLE: Inhibition of Th1. Rheumatology. 45:121–122.

    PubMed  CAS  Google Scholar 

  • Olsen NJ, Stein CM 2004. New drugs for rheumatoid arthritis. NEJM. 350:2167–2179.

    PubMed  CAS  Google Scholar 

  • Ortho Multicenter Transplant Study Group. 1985. A randomized clinical trial of OKT3 monoclonal antibody for acute rejection of cadaveric renal transplants. NEJM. 313:337–342.

    Google Scholar 

  • Pegram M, Hsu S, Lewis G, Pietras R. 1999. Inhibitory effects of combination of HER-2/neu antibody and chemotherapeutic agents used for treatment of human breast cancer. Oncogene. 18:2241–2251.

    PubMed  CAS  Google Scholar 

  • Pendley C, Schantz A, Wagner C. 2003. Immunogenicity of therapeutic monoclonal antibodies. Curr Opin Mol Ther. 5:172–179.

    PubMed  CAS  Google Scholar 

  • Penichet ML, Morrison SL. 2004. Designing and engineering human forms of monoclonal antibodies. Drug Deve Res. 61:121–136.

    CAS  Google Scholar 

  • Piccart-Gebhart MJ, Procter M, Leyland-Jones B, Goldhirsch A, et al. 2005. Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer. NEJM. 353:1659–1672.

    PubMed  CAS  Google Scholar 

  • Piccoli R, Olson KA, Vallee BL, Fett JW. 1998. Chimeric anti-angiogenin antibody cAb 26-2F inhibits the formation of human breast cancer xenograft in athymic mice. PNAS USA. 95:4579–4583.

    PubMed  CAS  Google Scholar 

  • Posner MR, Wirth LJ. 2006. Centuximab and radiotherapy for head and neck cancer. NEJM. 354:634–636.

    PubMed  CAS  Google Scholar 

  • Present D, Rutgeerts P, Targan S, Hanauer S, et al. 1999. Infliximab for the treatment of fistulas in patients with Crohn’s disease. NEJM. 340:1398–1405.

    PubMed  CAS  Google Scholar 

  • Presta LG, Lahr SJ, Shields RI, Porter JP, et al. 1993. Humanization of an antibody directed against IgE J Immunol. 151:2623–2632.

    PubMed  CAS  Google Scholar 

  • Przepiorka D, Kernan NA, Ipppoliti C, Papandopoulas EB, et al. 2000. Daclizumab, a humanized anti-interleukin-2 receptor alpha chain antibody, for the treatment of acute graft-versus-host disease Blood. 2000:83–89.

    Google Scholar 

  • Queen C, Schneider WP, Selick HE, Payne PW, et al. 1989. A humanized antibody that binds to the interleukin 2 receptors. PNAS USA. 86:10029–10033.

    PubMed  CAS  Google Scholar 

  • Rai KR, Freter CD, Mercier RJ, Cooper MR. 2002. Alemtuzumab in previously treated chronic lymphocytic leukemia patients who also had received Fludarabine. J Clin Oncol. 20:3891–3897.

    PubMed  CAS  Google Scholar 

  • Ramirez CB, Marino IR. 2007. The role of basiliximab induction therapy in organ transplantation. Expert Opin Biol Ther. 7:137–148.

    PubMed  CAS  Google Scholar 

  • Rawstron AC, Kennedy B, Moreton P, Dickinson AJ, et al. 2004. Early prediction of outcome and response to alemtuzumab therapy in chronic lymphocytic leukemia. Blood. 103:2027–2031.

    PubMed  CAS  Google Scholar 

  • Riechmann L, Clark M, Waldmann H, Winter G. 1988. Reshaping human antibodies for therapy. Nature. 332:323–327.

    PubMed  CAS  Google Scholar 

  • Ritz J, Schlossman SF. 1982. Utilization of monoclonal antibodies in the treatment of leukemia and lymphoma. Blood. 59:1–11.

    PubMed  CAS  Google Scholar 

  • Roskos LK, Davis CG, Schwag GM. 2004. The clinical pharmacology of therapeutic monoclonal antibodies. Drug Dev Res. 61:108–120.

    CAS  Google Scholar 

  • Rutgeerts P, Sanborn WJ, Feagan BG, Reinisch W, et al. 2005. Infliximab for induction and maintenance therapy for ulcerative colitis. NEJM. 353:2462–2476.

    PubMed  CAS  Google Scholar 

  • St. Clair EW. 2002. Infliximab treatment for rheumatic disease. Clinical and radiological efficacy. Ann Rehum Dis. 61:ii67–ii69.

    Google Scholar 

  • Sands B, Anderson F, Bernstein C, Chey W, et al. 2004. Infliximab maintenance therapy for fistulizing Crohn’s disease. NEJM. 350:876–885.

    PubMed  CAS  Google Scholar 

  • Scheinberg DA, Chapman BA. 1995. In: Birch JR, Lennox ES, Eds. Monoclonal Antibodies: Principles and Applications, Wiley-Liss, New York, pp. 45–105.

    Google Scholar 

  • Schmidt-Hieber M, Fietz T, Knauf W, Uharek L. 2005. Efficacy of the interleukin-2 receptor antagonist basiliximab in steroid refractory graft-versus-host disease. Br J Hemtaol. 130:568–574.

    CAS  Google Scholar 

  • Schmitz U, Versmold A, Kaufmann P, Frank HG. 2000. Phage display: A molecular tool for the generation of antibodies – a review. Placenta. 21:S106–S112.

    PubMed  Google Scholar 

  • Schrag D. 2004. The price tag on progress – chemotherapy for colorectal cancer. NEJM. 351:317–319.

    PubMed  CAS  Google Scholar 

  • Schroeder TJ, Michael AT, First MR, Hariharan S, et al. 1994. Variations in serum OKT3 concentration based upon age, sex, transplanted organ, treatment regimen and anti-OKT3 status. Ther Drug Monit. 16:361–367.

    PubMed  CAS  Google Scholar 

  • Sfikakis PP. 2002. Behcet’s disease: A new target for anti-tumour necrosis factor treatment. Ann Rheum Dis. 61:ii51–ii56.

    PubMed  Google Scholar 

  • Sharkey RM, GHoodenberg DM. 2006. Targeted therapy of cancer: New prospects for antibodies and immuno conjugates. CA Cancer J Clin. 56:226–243.

    PubMed  Google Scholar 

  • Shields CJ, Winter DC, Becker JM, Prushik SG, et al. 2006. Infliximab for ulcerative colitis. NEJM. 354:1424–1426.

    PubMed  CAS  Google Scholar 

  • Shimoni A, Zwas ST, Oksman Y, Hardan I, et al. 2007. Yttrium-90-ibritumomab tiuxetan (Zevalin) combined with high-dose BEAM chemotherapy and autologous stem cell transplantation for chemo-refractory aggressive non-Hodgkin’s lymphoma. Exp Hematol. 35:534–540.

    PubMed  CAS  Google Scholar 

  • Smith I, Procter M, Gelber RD, Guillaume S, et al. 2007. 2-year follow-up of trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer: A randomized controlled trial. Lancet. 369:29–36.

    PubMed  CAS  Google Scholar 

  • Song H, Du Y, Sgouros G, Prideaux A, et al. 2007. Therapeutic potential of 90Y and 131I-labeled anti-CD20 monoclonal antibody in treating non-Hodgkin’s lymphoma with pulmonary involvement. JNM. 48:150–157.

    PubMed  Google Scholar 

  • Stern M, Herrmann R. 2005. Overview of monoclonal antibodies in cancer therapy: Present and promise. Crit Rev Oncol Hematol. 54:11–29.

    PubMed  CAS  Google Scholar 

  • Tan P, Mitchell DA, Buss TN, Holmes MA, et al. 2002. Super humanized antibodies: Reduction of immunogenic potential by complementarity-determining region grafting with human germline sequences: Application to an anti-CD28. J Immunol. 169:1119–1125.

    PubMed  CAS  Google Scholar 

  • Topol EJ, Moliterno DJ, Hermann HC, Powers ER, et al. 2001. Comparison of two platelet glycoproteins IIb/IIIa inhibitors, Tirofiban and abciximab, for the prevention of ischemic events with precutaneous coronary revascularization. NEJM. 344:1888–1894.

    PubMed  CAS  Google Scholar 

  • Valabrega G, Montemurro F, Aglietta M. 2007. Trastuzumab: Mechanism of action, resistance and future perspectives in HER2-overexpressing breast cancer. Ann Oncol. 18:977–984.

    PubMed  CAS  Google Scholar 

  • Verbeek WHM, Mulder CJJ, Zweegman S, Vivas S, et al. 2006. Alemtuzumab for refractory celiac disease. NEJM. 355:1396–1397.

    PubMed  CAS  Google Scholar 

  • Verhoeyen M, Milstein C, Winter G. 1988. Reshaping human antibodies: Grafting an antilysozyme activity. Science. 239:1534–1536.

    PubMed  CAS  Google Scholar 

  • Vincenti F, Kirkman R, Light S, Bumgardner G, et al. 1998. Interleuin-2 receptor blockade with daclizumab to prevent acute rejection in renal transplantation. NEJM. 338:161–165.

    PubMed  CAS  Google Scholar 

  • Vivas S, Morales JM, Ramos F, Suarez-Vilela D. 2006. Alemtuzumab for refractory celiac disease in a patient at risk for enteropathy-associated T-cell lymphoma. NEJM. 354:23–24.

    Google Scholar 

  • Waldmann T.A. 1991. Monoclonal antibodies in diagnosis and treatment. Science. 252:1657–1662.

    PubMed  CAS  Google Scholar 

  • Waldmann TA, Levy R, Coller BS. 2000. Emerging therapies: Spectrum of applications of monoclonal antibody therapy. Hematology. 2000:394–408.

    Google Scholar 

  • Waldmann TA. 2003. Immunotherapy: Past, present and future. Nat Med. 9:269–277.

    PubMed  CAS  Google Scholar 

  • Waldmann TA. 2007. Anti-Tac (daclizumab, Zenapax) in the treatment of leukemia, autoimmune diseases and the prevention of allograft rejection: A 25-year personal odyssey. J Clin Immunol. 27:1–18.

    PubMed  CAS  Google Scholar 

  • Wellington K, Perry CM. 2005. Efalizumab. Am J clin Dermatol. 6:113–118.

    PubMed  Google Scholar 

  • White CA. 2004. Radioimmunotherapy in non-Hodgkin’s lymphoma: Focus on 90Y-ibritumonomab tiuxetan (Zevalin). J Exp Ther Oncol. 4:305–316.

    PubMed  CAS  Google Scholar 

  • Wiseman GA, Witzig, TE. 2005. Yttrium-90 (90Y) ibritumonomab tiuxetan (Zevalin) induces long-term durable responses in patients with relapsed or refractory B-cell non-Hodgkin’s lymphoma. Cancer Biother Radiopharm. 20:185–188.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Manzoor M. Khan Ph.D. .

Rights and permissions

Reprints and permissions

Copyright information

© 2008 Springer Science+Business Media, LLC

About this chapter

Cite this chapter

Khan, M.M. (2008). Monoclonal Antibodies as Therapeutic Agents. In: Immunopharmacology. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-77976-8_5

Download citation

Publish with us

Policies and ethics