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Nanotechnology for Cancer Vaccine Delivery

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Nanotechnology in Drug Delivery

Part of the book series: Biotechnology: Pharmaceutical Aspects ((PHARMASP,volume X))

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References

  • Akira, S., Takeda, K., & Kaisho, T. (2001). Toll-like receptors: Critical proteins linking innate and acquired immunity. Nat Immunol, 2(8), 675–680.

    CAS  PubMed  Google Scholar 

  • Alas, S., & Bonavida, B. (2003). Inhibition of constitutive stat3 activity sensitizes resistant non-Hodgkin's lymphoma and multiple myeloma to chemotherapeutic drug-mediated apoptosis. Clin Cancer Res, 9(1), 316–326.

    CAS  PubMed  Google Scholar 

  • Albert, M. L., Sauter, B., & Bhardwaj, N. (1998). Dendritic cells acquire antigen from apoptotic cells and induce class i-restricted ctls. Nature, 392(6671), 86–89.

    CAS  PubMed  Google Scholar 

  • Albertsson, P. A., Basse, P. H., Hokland, M., Goldfarb, R. H., Nagelkerke, J. F., Nannmark, U., et al. (2003). Nk cells and the tumour microenvironment: Implications for nk-cell function and anti-tumour activity. Trends Immunol, 24(11), 603–609.

    CAS  PubMed  Google Scholar 

  • Banchereau, J., & Palucka, A. K. (2005). Dendritic cells as therapeutic vaccines against cancer. Nat Rev Immunol, 5(4), 296–306.

    CAS  PubMed  Google Scholar 

  • Banchereau, J., & Steinman, R. M. (1998). Dendritic cells and the control of immunity. Nature, 392(6673), 245–252.

    CAS  PubMed  Google Scholar 

  • Bernards, R., Destree, A., McKenzie, S., Gordon, E., Weinberg, R. A., & Panicali, D. (1987). Effective tumor immunotherapy directed against an oncogene-encoded product using a vaccinia virus vector. Proc Natl Acad Sci USA, 84(19), 6854–6858.

    Google Scholar 

  • Beutler, B. (2004). Inferences, questions and possibilities in toll-like receptor signalling. Nature, 430(6996), 257–263.

    CAS  PubMed  Google Scholar 

  • Blaskovich, M. A., Sun, J., Cantor, A., Turkson, J., Jove, R., & Sebti, S. M. (2003). Discovery of jsi-124 (cucurbitacin i), a selective janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice. Cancer Res, 63, 1270–1279.

    CAS  PubMed  Google Scholar 

  • Borst, J., Hendriks, J., & Xiao, Y. (2005). Cd27 and cd70 in t cell and b cell activation. Curr Opin Immunol, 17(3), 275–281.

    CAS  PubMed  Google Scholar 

  • Bousso, P., & Robey, E. (2003). Dynamics of cd8+ t cell priming by dendritic cells in intact lymph nodes. Nat Immunol, 4(6), 579–585.

    CAS  PubMed  Google Scholar 

  • Brandacher, G., Winkler, C., Schroecksnadel, K., Margreiter, R., & Fuchs, D. (2006). Antitumoral activity of interferon-gamma involved in impaired immune function in cancer patients. Curr Drug Metab, 7(6), 599–612.

    CAS  PubMed  Google Scholar 

  • Brigl, M., & Brenner, M. B. (2004). Cd1: Antigen presentation and t cell function. Annu Rev Immunol, 22, 817–890.

    CAS  PubMed  Google Scholar 

  • Cady, S. G., & Sono, M. (1991). 1-methyl-dl-tryptophan, beta-(3-benzofuranyl)-dl-alanine (the oxygen analog of tryptophan), and beta-[3-benzo(b)thienyl]-dl-alanine (the sulfur analog of tryptophan) are competitive inhibitors for indoleamine 2,3-dioxygenase. Arch Biochem Biophys, 291(2), 326–333.

    CAS  PubMed  Google Scholar 

  • Casadevall, A. (1999). Passive antibody therapies: Progress and continuing challenges. Clin Immunol, 93(1), 5–15.

    CAS  PubMed  Google Scholar 

  • Cella, M., Engering, A., Pinet, V., Pieters, J., & Lanzavecchia, A. (1997). Inflammatory stimuli induce accumulation of mhc class ii complexes on dendritic cells. Nature, 388(6644), 782–787.

    CAS  PubMed  Google Scholar 

  • Chang, D. H., Osman, K., Connolly, J., Kukreja, A., Krasovsky, J., Pack, M., et al. (2005). Sustained expansion of nkt cells and antigen-specific t cells after injection of alpha-galactosyl-ceramide loaded mature dendritic cells in cancer patients. J Exp Med, 201(9), 1503–1517.

    CAS  PubMed  Google Scholar 

  • Chaux, P., Moutet, M., Faivre, J., Martin, F., & Martin, M. (1996). Inflammatory cells infiltrating human colorectal carcinomas express hla class ii but not b7-1 and b7-2 costimulatory molecules of the t-cell activation. Lab Invest, 74(5), 975–983.

    CAS  PubMed  Google Scholar 

  • Cheng, F., Wang, H. W., Cuenca, A., Huang, M., Ghansah, T., Brayer, J., et al. (2003). A critical role for stat3 signaling in immune tolerance. Immunity, 19(3), 425–436.

    CAS  PubMed  Google Scholar 

  • Chiu, Y. L., Ali, A., Chu, C. Y., Cao, H., & Rana, T. M. (2004). Visualizing a correlation between sirna localization, cellular uptake, and rnai in living cells. Chem Biol, 11(8), 1165–1175.

    CAS  PubMed  Google Scholar 

  • Cooper, M. A., Fehniger, T. A., Fuchs, A., Colonna, M., & Caligiuri, M. A. (2004). Nk cell and dc interactions. Trends Immunol, 25(1), 47–52.

    CAS  PubMed  Google Scholar 

  • Copland, M. J., Baird, M. A., Rades, T., McKenzie, J. L., Becker, B., Reck, F., et al. (2003). Liposomal delivery of antigen to human dendritic cells. Vaccine, 21(9–10), 883–890.

    CAS  PubMed  Google Scholar 

  • Cumberbatch, M., & Kimber, I. (1995). Tumour necrosis factor-alpha is required for accumulation of dendritic cells in draining lymph nodes and for optimal contact sensitization. Immunology, 84(1), 31–35.

    CAS  PubMed  Google Scholar 

  • Datta, S. K., Redecke, V., Prilliman, K. R., Takabayashi, K., Corr, M., Tallant, T., et al. (2003). A subset of toll-like receptor ligands induces cross-presentation by bone marrow-derived dendritic cells. J Immunol, 170(8), 4102–4110.

    CAS  PubMed  Google Scholar 

  • De Vries, I. J., Krooshoop, D. J., Scharenborg, N. M., Lesterhuis, W. J., Diepstra, J. H., Van Muijen, G. N., et al. (2003). Effective migration of antigen-pulsed dendritic cells to lymph nodes in melanoma patients is determined by their maturation state. Cancer Res, 63(1), 12–17.

    PubMed  Google Scholar 

  • Degli-Esposti, M. A., & Smyth, M. J. (2005). Close encounters of different kinds: Dendritic cells and nk cells take centre stage. Nat Rev Immunol, 5(2), 112–124.

    CAS  PubMed  Google Scholar 

  • Dermime, S., Armstrong, A., Hawkins, R. E., & Stern, P. L. (2002). Cancer vaccines and immunotherapy. Br Med Bull, 62, 149–162.

    PubMed  Google Scholar 

  • Dhodapkar, M. V., Steinman, R. M., Krasovsky, J., Munz, C., & Bhardwaj, N. (2001). Antigen-specific inhibition of effector t cell function in humans after injection of immature dendritic cells. J Exp Med, 193(2), 233–238.

    CAS  PubMed  Google Scholar 

  • Diehl, L., den Boer, A. T., Schoenberger, S. P., van der Voort, E. I., Schumacher, T. N., Melief, C. J., et al. (1999). Cd40 activation in vivo overcomes peptide-induced peripheral cytotoxic t-lymphocyte tolerance and augments anti-tumor vaccine efficacy. Nat Med, 5(7), 774–779.

    CAS  PubMed  Google Scholar 

  • Diwan, M., Elamanchili, P., Cao, M., & Samuel, J. (2004). Dose sparing of cpg oligodeoxynucleotide vaccine adjuvants by nanoparticle delivery. Curr Drug Deliv, 1(4), 405–412.

    CAS  PubMed  Google Scholar 

  • Diwan, M., Elamanchili, P., Lane, H., Gainer, A., & Samuel, J. (2003). Biodegradable nanoparticle mediated antigen delivery to human cord blood derived dendritic cells for induction of primary t cell responses. J Drug Target, 11(8–10), 495–507.

    CAS  PubMed  Google Scholar 

  • Elamanchili, P., Lutsiak, C., Hamdy, S., Diwan, M., & Samuel, J. (2007). Pathogen-mimicking' nanoparticles for vaccine delivery to dendritic cells. J Immunother, 30(4), 378–395.

    Google Scholar 

  • Elamanchili, P., Diwan, M., Cao, M., & Samuel, J. (2004). Characterization of poly(d,l-lactic-co-glycolic acid) based nanoparticulate system for enhanced delivery of antigens to dendritic cells. Vaccine, 22(19), 2406–2412.

    CAS  PubMed  Google Scholar 

  • Enk, A. H., Jonuleit, H., Saloga, J., & Knop, J. (1997). Dendritic cells as mediators of tumor-induced tolerance in metastatic melanoma. Int J Cancer, 73(3), 309–316.

    CAS  PubMed  Google Scholar 

  • Fehervari, Z., & Sakaguchi, S. (2004). Control of foxp3+ cd25+cd4+ regulatory cell activation and function by dendritic cells. Int Immunol, 16(12), 1769–1780.

    CAS  PubMed  Google Scholar 

  • Foged, C., Sundblad, A., & Hovgaard, L. (2002). Targeting vaccines to dendritic cells. Pharm Res, 19(3), 229–238.

    CAS  PubMed  Google Scholar 

  • Friberg, M., Jennings, R., Alsarraj, M., Dessureault, S., Cantor, A., Extermann, M., et al. (2002). Indoleamine 2,3-dioxygenase contributes to tumor cell evasion of t cell-mediated rejection. Int J Cancer, 101(2), 151–155.

    CAS  PubMed  Google Scholar 

  • Fujii, S., Shimizu, K., Smith, C., Bonifaz, L., & Steinman, R. M. (2003). Activation of natural killer t cells by alpha-galactosylceramide rapidly induces the full maturation of dendritic cells in vivo and thereby acts as an adjuvant for combined cd4 and cd8 t cell immunity to a coadministered protein. J Exp Med, 198(2), 267–279.

    CAS  PubMed  Google Scholar 

  • Gabrilovich, D. I., Corak, J., Ciernik, I. F., Kavanaugh, D., & Carbone, D. P. (1997). Decreased antigen presentation by dendritic cells in patients with breast cancer. Clin Cancer Res, 3(3), 483–490.

    CAS  PubMed  Google Scholar 

  • Gao, L., Zhang, L., Hu, J., Li, F., Shao, Y., Zhao, D., et al. (2005a). Down-regulation of signal transducer and activator of transcription 3 expression using vector-based small interfering rnas suppresses growth of human prostate tumor in vivo. Clin Cancer Res, 11(17), 6333–6341.

    CAS  Google Scholar 

  • Gao, L. F., Xu, D. Q., Wen, L. J., Zhang, X. Y., Shao, Y. T., & Zhao, X. J. (2005b). Inhibition of stat3 expression by sirna suppresses growth and induces apoptosis in laryngeal cancer cells. Acta Pharmacol Sin, 26(3), 377–383.

    CAS  Google Scholar 

  • Gao, L. F., Wen, L. J., Yu, H., Zhang, L., Meng, Y., Shao, Y. T., et al. (2006). Knockdown of stat3 expression using rnai inhibits growth of laryngeal tumors in vivo. Acta Pharmacol Sin, 27(3), 347–352.

    CAS  PubMed  Google Scholar 

  • Garg, S., Oran, A., Wajchman, J., Sasaki, S., Maris, C. H., Kapp, J. A., et al. (2003). Genetic tagging shows increased frequency and longevity of antigen-presenting, skin-derived dendritic cells in vivo. Nat Immunol, 4(9), 907–912.

    CAS  PubMed  Google Scholar 

  • Gaspari, P., Banerjee, T., Malachowski, W. P., Muller, A. J., Prendergast, G. C., DuHadaway, J., et al. (2006). Structure-activity study of brassinin derivatives as indoleamine 2,3-dioxygenase inhibitors. J Med Chem, 49(2), 684–692.

    CAS  PubMed  Google Scholar 

  • Geng, D., Joshi, S. K., Podolsky, R., & She, J. X. (2007). Gcsf receptor regulates antigen uptake and expression of cytokines and costimulatory molecules in dendritic cells. Mol Immunol, 44(4), 521–529.

    CAS  PubMed  Google Scholar 

  • Gerosa, F., Baldani-Guerra, B., Nisii, C., Marchesini, V., Carra, G., & Trinchieri, G. (2002). Reciprocal activating interaction between natural killer cells and dendritic cells. J Exp Med, 195(3), 327–333.

    CAS  PubMed  Google Scholar 

  • Godfrey, D. I., & Kronenberg, M. (2004). Going both ways: Immune regulation via cd1d-dependent nkt cells. J Clin Invest, 114(10), 1379–1388.

    CAS  PubMed  Google Scholar 

  • Gong, J., Chen, D., Kashiwaba, M., & Kufe, D. (1997). Induction of antitumor activity by immunization with fusions of dendritic and carcinoma cells. Nat Med, 3(5), 558–561.

    CAS  PubMed  Google Scholar 

  • Hamdy, S., Elamanchili, P., Alshamsan, A., Molavi, O., Satou, T., & Samuel, J. (2007). Enhanced antigen-specific primary cd4+ and cd8+ responses by co-delivery of ovalbumin and toll-like receptor ligand monophosphoryl lipid a in poly(d,l-lactic-co-glycolic acid) nanoparticles. J Biomed Mater Res A, 81(3), 652–662.

    Google Scholar 

  • Heikenwalder, M., Polymenidou, M., Junt, T., Sigurdson, C., Wagner, H., Akira, S., et al. (2004). Lymphoid follicle destruction and immunosuppression after repeated cpg oligodeoxynucleotide administration. Nat Med, 10(2), 187–192.

    CAS  PubMed  Google Scholar 

  • Heit, A., Huster, K. M., Schmitz, F., Schiemann, M., Busch, D. H., & Wagner, H. (2004). Cpg-DNA aided cross-priming by cross-presenting b cells. J Immunol, 172(3), 1501–1507.

    CAS  PubMed  Google Scholar 

  • Hertz, C. J., Kiertscher, S. M., Godowski, P. J., Bouis, D. A., Norgard, M. V., Roth, M. D., et al. (2001). Microbial lipopeptides stimulate dendritic cell maturation via toll-like receptor 2. J Immunol, 166(4), 2444–2450.

    CAS  PubMed  Google Scholar 

  • Hill, J. A., Ichim, T. E., Kusznieruk, K. P., Li, M., Huang, X., Yan, X., et al. (2003). Immune modulation by silencing il-12 production in dendritic cells using small interfering rna. J Immunol, 171(2), 691–696.

    CAS  PubMed  Google Scholar 

  • Hirao, M., Onai, N., Hiroishi, K., Watkins, S. C., Matsushima, K., Robbins, P. D., et al. (2000). Cc chemokine receptor-7 on dendritic cells is induced after interaction with apoptotic tumor cells: Critical role in migration from the tumor site to draining lymph nodes. Cancer Res, 60(8), 2209–2217.

    CAS  PubMed  Google Scholar 

  • Howard, K. A., Rahbek, U. L., Liu, X., Damgaard, C. K., Glud, S. Z., Andersen, M. O., et al. (2006). Rna interference in vitro and in vivo using a novel chitosan/sirna nanoparticle system. Mol Ther, 14(4), 476–484.

    CAS  PubMed  Google Scholar 

  • Hwu, P., Du, M. X., Lapointe, R., Do, M., Taylor, M. W., & Young, H. A. (2000). Indoleamine 2,3-dioxygenase production by human dendritic cells results in the inhibition of t cell proliferation. J Immunol, 164(7), 3596–3599.

    CAS  PubMed  Google Scholar 

  • Itaka, K., Kanayama, N., Nishiyama, N., Jang, W. D., Yamasaki, Y., Nakamura, K., et al. (2004). Supramolecular nanocarrier of sirna from peg-based block catiomer carrying diamine side chain with distinctive pka directed to enhance intracellular gene silencing. J Am Chem Soc, 126(42), 13612–13613.

    CAS  PubMed  Google Scholar 

  • Iwasaki, A., & Medzhitov, R. (2004). Toll-like receptor control of the adaptive immune responses. Nat Immunol, 5(10), 987–995.

    CAS  PubMed  Google Scholar 

  • Jonuleit, H., Schmitt, E., Schuler, G., Knop, J., & Enk, A. H. (2000). Induction of interleukin 10-producing, nonproliferating cd4(+) t cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells. J Exp Med, 192(9), 1213–1222.

    CAS  PubMed  Google Scholar 

  • Kakizawa, Y., Furukawa, S., & Kataoka, K. (2004). Block copolymer-coated calcium phosphate nanoparticles sensing intracellular environment for oligodeoxynucleotide and sirna delivery. J Control Release, 97(2), 345–356.

    CAS  PubMed  Google Scholar 

  • Kamath, A. T., Sheasby, C. E., & Tough, D. F. (2005). Dendritic cells and nk cells stimulate bystander t cell activation in response to tlr agonists through secretion of ifn-alpha beta and ifn-gamma. J Immunol, 174(2), 767–776.

    CAS  PubMed  Google Scholar 

  • Kaufman, H. L., & Disis, M. L. (2004). Immune system versus tumor: Shifting the balance in favor of dcs and effective immunity. J Clin Invest, 113(5), 664–667.

    CAS  PubMed  Google Scholar 

  • Kawano, T., Cui, J., Koezuka, Y., Toura, I., Kaneko, Y., Motoki, K., et al. (1997). Cd1d-restricted and tcr-mediated activation of valpha14 nkt cells by glycosylceramides. Science, 278(5343), 1626–1629.

    CAS  PubMed  Google Scholar 

  • Khaled, A., Guo, S., Li, F., & Guo, P. (2005). Controllable self-assembly of nanoparticles for specific delivery of multiple therapeutic molecules to cancer cells using rna nanotechnology. Nano Lett, 5(9), 1797–1808.

    CAS  PubMed  Google Scholar 

  • Khan, A., Benboubetra, M., Sayyed, P. Z., Ng, K. W., Fox, S., Beck, G., et al. (2004). Sustained polymeric delivery of gene silencing antisense odns, sirna, dnazymes and ribozymes: In vitro and in vivo studies. J Drug Target, 12(6), 393–404.

    CAS  PubMed  Google Scholar 

  • Kitamura, H., Iwakabe, K., Yahata, T., Nishimura, S., Ohta, A., Ohmi, Y., et al. (1999). The natural killer t (nkt) cell ligand alpha-galactosylceramide demonstrates its immunopotentiating effect by inducing interleukin (il)-12 production by dendritic cells and il-12 receptor expression on nkt cells. J Exp Med, 189(7), 1121–1128.

    CAS  PubMed  Google Scholar 

  • Konnikova, L., Kotecki, M., Kruger, M. M., & Cochran, B. H. (2003). Knockdown of stat3 expression by rnai induces apoptosis in astrocytoma cells. BMC Cancer, 3, 23.

    PubMed  Google Scholar 

  • Kortylewski, M., Kujawski, M., Wang, T., Wei, S., Zhang, S., Pilon-Thomas, S., et al. (2005). Inhibiting stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity. Nat Med, 11(12), 1314–1321.

    CAS  PubMed  Google Scholar 

  • Kowalczyk, D. W., Wysocki, P. J., & Mackiewicz, A. (2003). Cancer immunotherapy using cells modified with cytokine genes. Acta Biochim Pol, 50(3), 613–624.

    CAS  PubMed  Google Scholar 

  • Kubo, T., Hatton, R. D., Oliver, J., Liu, X., Elson, C. O., & Weaver, C. T. (2004). Regulatory t cell suppression and anergy are differentially regulated by proinflammatory cytokines produced by tlr-activated dendritic cells. J Immunol, 173(12), 7249–7258.

    CAS  PubMed  Google Scholar 

  • Kunisawa, J., Masuda, T., Katayama, K., Yoshikawa, T., Tsutsumi, Y., Akashi, M., et al. (2005). Fusogenic liposome delivers encapsulated nanoparticles for cytosolic controlled gene release. J Control Release, 105(3), 344–353.

    CAS  PubMed  Google Scholar 

  • Laderach, D., Compagno, D., Danos, O., Vainchenker, W., & Galy, A. (2003). Rna interference shows critical requirement for nf-kappa b p50 in the production of il-12 by human dendritic cells. J Immunol, 171(4), 1750–1757.

    CAS  PubMed  Google Scholar 

  • Lathe, R., Kieny, M. P., Gerlinger, P., Clertant, P., Guizani, I., Cuzin, F., et al. (1987). Tumour prevention and rejection with recombinant vaccinia. Nature, 326(6116), 878–880.

    CAS  PubMed  Google Scholar 

  • Lee, J. R., Dalton, R. R., Messina, J. L., Sharma, M. D., Smith, D. M., Burgess, R. E., et al. (2003). Pattern of recruitment of immunoregulatory antigen-presenting cells in malignant melanoma. Lab Invest, 83(10), 1457–1466.

    CAS  PubMed  Google Scholar 

  • Lee, S. O., Lou, W., Qureshi, K. M., Mehraein-Ghomi, F., Trump, D. L., & Gao, A. C. (2004). Rna interference targeting stat3 inhibits growth and induces apoptosis of human prostate cancer cells. Prostate, 60(4), 303–309.

    CAS  PubMed  Google Scholar 

  • Liu, G., Ng, H., Akasaki, Y., Yuan, X., Ehtesham, M., Yin, D., et al. (2004). Small interference rna modulation of il-10 in human monocyte-derived dendritic cells enhances the th1 response. Eur J Immunol, 34(6), 1680–1687.

    CAS  PubMed  Google Scholar 

  • Lutsiak, C. M., Sosnowski, D. L., Wishart, D. S., Kwon, G. S., & Samuel, J. (1998). Use of a liposome antigen delivery system to alter immune responses in vivo. J Pharm Sci, 87(11), 1428–1432.

    CAS  PubMed  Google Scholar 

  • Lutsiak, M. E., Kwon, G. S., & Samuel, J. (2006). Biodegradable nanoparticle delivery of a th2-biased peptide for induction of th1 immune responses. J Pharm Pharmacol, 58(6), 739–747.

    CAS  PubMed  Google Scholar 

  • Mack, C. A., Song, W. R., Carpenter, H., Wickham, T. J., Kovesdi, I., Harvey, B. G., et al. (1997). Circumvention of anti-adenovirus neutralizing immunity by administration of an adenoviral vector of an alternate serotype. Hum Gene Ther, 8(1), 99–109.

    CAS  PubMed  Google Scholar 

  • Means, T. K., Hayashi, F., Smith, K. D., Aderem, A., & Luster, A. D. (2003). The toll-like receptor 5 stimulus bacterial flagellin induces maturation and chemokine production in human dendritic cells. J Immunol, 170(10), 5165–5175.

    CAS  PubMed  Google Scholar 

  • Melief, C. J., Van Der Burg, S. H., Toes, R. E., Ossendorp, F., & Offringa, R. (2002). Effective therapeutic anticancer vaccines based on precision guiding of cytolytic t lymphocytes. Immunol Rev, 188, 177–182.

    CAS  PubMed  Google Scholar 

  • Mercer, J. C., Ragin, M. J., & August, A. (2005). Natural killer t cells: Rapid responders controlling immunity and disease. Int J Biochem Cell Biol, 37(7), 1337–1343.

    CAS  PubMed  Google Scholar 

  • Mesa, C., & Fernandez, L. E. (2004). Challenges facing adjuvants for cancer immunotherapy. Immunol Cell Biol, 82(6), 644–650.

    CAS  PubMed  Google Scholar 

  • Muller, A. J., DuHadaway, J. B., Donover, P. S., Sutanto-Ward, E., & Prendergast, G. C. (2005). Inhibition of indoleamine 2,3-dioxygenase, an immunoregulatory target of the cancer suppression gene bin1, potentiates cancer chemotherapy. Nat Med, 11(3), 312–319.

    CAS  PubMed  Google Scholar 

  • Muller, A. J., & Prendergast, G. C. (2005). Marrying immunotherapy with chemotherapy: Why say ido? Cancer Res, 65(18), 8065–8068.

    CAS  PubMed  Google Scholar 

  • Munn, D. H., & Mellor, A. L. (2004). Ido and tolerance to tumors. Trends Mol Med, 10(1), 15–18.

    CAS  PubMed  Google Scholar 

  • Munn, D. H., Sharma, M. D., Hou, D., Baban, B., Lee, J. R., Antonia, S. J., et al. (2004). Expression of indoleamine 2,3-dioxygenase by plasmacytoid dendritic cells in tumor-draining lymph nodes. J Clin Invest, 114(2), 280–290.

    CAS  PubMed  Google Scholar 

  • Murthy N, C. J., Fausto N, Hoffman AS, Stayton PS. (2003). Bioinspired ph-responsive polymers for the intracellular delivery of biomolecular drugs. Bioconjug Chem, 14(2), 412–419.

    Google Scholar 

  • Neeson, P., & Paterson, Y. (2006). Effects of the tumor microenvironment on the efficacy of tumor immunotherapy. Immunol Invest, 35(3–4), 359–394.

    CAS  PubMed  Google Scholar 

  • Nefedova, Y., Cheng, P., Gilkes, D., Blaskovich, M., Beg, A. A., Sebti, S. M., et al. (2005a). Activation of dendritic cells via inhibition of jak2/stat3 signaling. J Immunol, 175(7), 4338–4346.

    CAS  Google Scholar 

  • Nefedova, Y., Nagaraj, S., Rosenbauer, A., Muro-Cacho, C., Sebti, S. M., & Gabrilovich, D. I. (2005b). Regulation of dendritic cell differentiation and antitumor immune response in cancer by pharmacologic-selective inhibition of the janus-activated kinase 2/signal transducers and activators of transcription 3 pathway. Cancer Res, 65(20), 9525–9535.

    CAS  Google Scholar 

  • Nefedova, Y., Huang, M., Kusmartsev, S., Bhattacharya, R., Cheng, P., Salup, R., et al. (2004). Hyperactivation of stat3 is involved in abnormal differentiation of dendritic cells in cancer. J Immunol, 172(1), 464–474.

    CAS  PubMed  Google Scholar 

  • Nestle, F. O., Alijagic, S., Gilliet, M., Sun, Y., Grabbe, S., Dummer, R., et al. (1998). Vaccination of melanoma patients with peptide- or tumor lysate-pulsed dendritic cells. Nat Med, 4(3), 328–332.

    CAS  PubMed  Google Scholar 

  • Nestle, F. O., Banchereau, J., & Hart, D. (2001). Dendritic cells: On the move from bench to bedside. Nat Med, 7(7), 761–765.

    CAS  PubMed  Google Scholar 

  • Newman, K. D., Samuel, J., & Kwon, G. (1998). Ovalbumin peptide encapsulated in poly(d,l lactic-co-glycolic acid) microspheres is capable of inducing a t helper type 1 immune response. J Control Release, 54(1), 49–59.

    CAS  PubMed  Google Scholar 

  • Nicchitta, C. V. (2003). Re-evaluating the role of heat-shock protein-peptide interactions in tumour immunity. Nat Rev Immunol, 3(5), 427–432.

    CAS  PubMed  Google Scholar 

  • Nishioka, Y., & Yoshino, H. (2001). Lymphatic targeting with nanoparticulate system. Adv Drug Deliv Rev, 47(1), 55–64.

    CAS  PubMed  Google Scholar 

  • Niu, G., Heller, R., Catlett-Falcone, R., Coppola, D., Jaroszeski, M., Dalton, W., et al. (1999). Gene therapy with dominant-negative stat3 suppresses growth of the murine melanoma b16 tumor in vivo. Cancer Res, 59, 5059–5063.

    CAS  PubMed  Google Scholar 

  • O'Hagan D, S. M. (2003). Microparticles as vaccine adjuvants and delivery systems. Expert Rev Vaccines, 2, 269–283.

    PubMed  Google Scholar 

  • O'Hagan, D. T., & Valiante, N. M. (2003). Recent advances in the discovery and delivery of vaccine adjuvants. Nat Rev Drug Discov, 2(9), 727–735.

    PubMed  Google Scholar 

  • Orabona, C., Belladonna, M. L., Vacca, C., Bianchi, R., Fallarino, F., Volpi, C., et al. (2005). Cutting edge: Silencing suppressor of cytokine signaling 3 expression in dendritic cells turns cd28-ig from immune adjuvant to suppressant. J Immunol, 174(11), 6582–6586.

    CAS  PubMed  Google Scholar 

  • Oussoren, C., & Storm, G. (1997). Lymphatic uptake and biodistribution of liposomes after subcutaneous injection: Iii. Influence of surface modification with poly(ethyleneglycol). Pharm Res, 14(10), 1479–1484.

    CAS  PubMed  Google Scholar 

  • Oussoren, C., & Storm, G. (2001). Liposomes to target the lymphatics by subcutaneous administration. Adv Drug Deliv Rev, 50(1–2), 143–156.

    CAS  PubMed  Google Scholar 

  • Palmer, M., Parker, J., Modi, S., Butts, C., Smylie, M., Meikle, A., et al. (2001). Phase i study of the blp25 (muc1 peptide) liposomal vaccine for active specific immunotherapy in stage iiib/iv non-small-cell lung cancer. Clin Lung Cancer, 3(1), 49–57; discussion 58.

    CAS  PubMed  Google Scholar 

  • Pasare, C., & Medzhitov, R. (2003). Toll pathway-dependent blockade of cd4+cd25+ t cell-mediated suppression by dendritic cells. Science, 299(5609), 1033–1036.

    CAS  PubMed  Google Scholar 

  • Pinzon-Charry, A., Maxwell, T., & Lopez, J. A. (2005). Dendritic cell dysfunction in cancer: A mechanism for immunosuppression. Immunol Cell Biol, 83(5), 451–461.

    CAS  PubMed  Google Scholar 

  • Probst, H. C., Lagnel, J., Kollias, G., & van den Broek, M. (2003). Inducible transgenic mice reveal resting dendritic cells as potent inducers of cd8+ t cell tolerance. Immunity, 18(5), 713–720.

    CAS  PubMed  Google Scholar 

  • Razzaque, A., Dye, E., & Puri, R. K. (2000). Characterization of tumor vaccines during product development. Vaccine, 19(6), 644–647.

    CAS  PubMed  Google Scholar 

  • Reddy, S. T., Berk, D. A., Jain, R. K., & Swartz, M. A. (2006a). A sensitive in vivo model for quantifying interstitial convective transport of injected macromolecules and nanoparticles. J Appl Physiol, 101(4), 1162–1169.

    CAS  Google Scholar 

  • Reddy, S. T., Rehor, A., Schmoekel, H. G., Hubbell, J. A., & Swartz, M. A. (2006b). In vivo targeting of dendritic cells in lymph nodes with poly(propylene sulfide) nanoparticles. J Control Release, 112(1), 26–34.

    CAS  Google Scholar 

  • Reddy, S. T., Swartz, M. A., & Hubbell, J. A. (2006c). Targeting dendritic cells with biomaterials: Developing the next generation of vaccines. Trends Immunol, 27(12), 573–579.

    CAS  Google Scholar 

  • Rehor, A., Hubbell, J. A., & Tirelli, N. (2005). Oxidation-sensitive polymeric nanoparticles. Langmuir, 21(1), 411–417.

    CAS  PubMed  Google Scholar 

  • Richards Grayson, A. C., Doody, A. M., & Putnam, D. (2006). Biophysical and structural characterization of polyethylenimine-mediated sirna delivery in vitro. Pharm Res, 23(8), 1868–1876.

    Google Scholar 

  • Rosenberg, S. A., Yang, J. C., & Restifo, N. P. (2004). Cancer immunotherapy: Moving beyond current vaccines. Nat Med, 10(9), 909–915.

    CAS  PubMed  Google Scholar 

  • Schroder, M., & Bowie, A. G. (2005). Tlr3 in antiviral immunity: Key player or bystander? Trends Immunol, 26(9), 462–468.

    PubMed  Google Scholar 

  • Schulz, O., Diebold, S. S., Chen, M., Naslund, T. I., Nolte, M. A., Alexopoulou, L., et al. (2005). Toll-like receptor 3 promotes cross-priming to virus-infected cells. Nature, 433(7028), 887–892.

    CAS  PubMed  Google Scholar 

  • Schuster, M., Nechansky, A., & Kircheis, R. (2006). Cancer immunotherapy. Biotechnol J, 1(2), 138–147.

    CAS  PubMed  Google Scholar 

  • Shen, H., Ackerman, A. L., Cody, V., Giodini, A., Hinson, E. R., Cresswell, P., et al. (2006). Enhanced and prolonged cross-presentation following endosomal escape of exogenous antigens encapsulated in biodegradable nanoparticles. Immunology, 117(1), 78–88.

    CAS  PubMed  Google Scholar 

  • Smyth, M. J., Crowe, N. Y., Hayakawa, Y., Takeda, K., Yagita, H., & Godfrey, D. I. (2002). Nkt cells – conductors of tumor immunity? Curr Opin Immunol, 14(2), 165–171.

    CAS  PubMed  Google Scholar 

  • Smyth, M. J., Hayakawa, Y., Takeda, K., & Yagita, H. (2002). New aspects of natural-killer-cell surveillance and therapy of cancer. Nat Rev Cancer, 2(11), 850–861.

    CAS  PubMed  Google Scholar 

  • Takeda, K., Kaisho, T., & Akira, S. (2003). Toll-like receptors. Annu Rev Immunol, 21, 335–376.

    CAS  PubMed  Google Scholar 

  • Tamura, Y., Peng, P., Liu, K., Daou, M., & Srivastava, P. K. (1997). Immunotherapy of tumors with autologous tumor-derived heat shock protein preparations. Science, 278(5335), 117–120.

    CAS  PubMed  Google Scholar 

  • Terness, P., Chuang, J. J., Bauer, T., Jiga, L., & Opelz, G. (2005). Regulation of human auto- and alloreactive t cells by indoleamine 2,3-dioxygenase (ido)-producing dendritic cells: Too much ado about ido? Blood, 105(6), 2480–2486.

    CAS  PubMed  Google Scholar 

  • Tsujitani, S., Furukawa, T., Tamada, R., Okamura, T., Yasumoto, K., & Sugimachi, K. (1987). Langerhans cells and prognosis in patients with gastric carcinoma. Cancer, 59(3), 501–505.

    CAS  PubMed  Google Scholar 

  • Turkson, J., Ryan, D., Kim, J. S., Zhang, Y., Chen, Z., Haura, E., et al. (2001). Phosphotyrosyl peptides block stat3-mediated dna binding activity, gene regulation, and cell transformation. J Biol Chem, 276(48), 45443–45455.

    CAS  PubMed  Google Scholar 

  • Tuting, T., Storkus, W. J., & Lotze, M. T. (1997). Gene-based strategies for the immunotherapy of cancer. J Mol Med, 75(7), 478–491.

    CAS  PubMed  Google Scholar 

  • Uyttenhove, C., Pilotte, L., Theate, I., Stroobant, V., Colau, D., Parmentier, N., et al. (2003). Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase. Nat Med, 9(10), 1269–1274.

    CAS  PubMed  Google Scholar 

  • van Duin, D., Medzhitov, R., & Shaw, A. C. (2006). Triggering tlr signaling in vaccination. Trends Immunol, 27(1), 49–55.

    PubMed  Google Scholar 

  • Walter, E., Dreher, D., Kok, M., Thiele, L., Kiama, S. G., Gehr, P., et al. (2001). Hydrophilic poly(dl-lactide-co-glycolide) microspheres for the delivery of dna to human-derived macrophages and dendritic cells. J Control Release, 76(1–2), 149–168.

    CAS  PubMed  Google Scholar 

  • Walzer, T., Dalod, M., Robbins, S. H., Zitvogel, L., & Vivier, E. (2005). Natural-killer cells and dendritic cells: “l'union fait la force”. Blood, 106(7), 2252–2258.

    CAS  PubMed  Google Scholar 

  • Wan, T., Zhou, X., Chen, G., An, H., Chen, T., Zhang, W., et al. (2004). Novel heat shock protein hsp70l1 activates dendritic cells and acts as a th1 polarizing adjuvant. Blood, 103(5), 1747–1754.

    CAS  PubMed  Google Scholar 

  • Wang, D., Robinson, D. R., Kwon, G. S., & Samuel, J. (1999). Encapsulation of plasmid dna in biodegradable poly(d, l-lactic-co-glycolic acid) microspheres as a novel approach for immunogene delivery. J Control Release, 57(1), 9–18.

    CAS  PubMed  Google Scholar 

  • Warger, T., Osterloh, P., Rechtsteiner, G., Fassbender, M., Heib, V., Schmid, B., et al. (2006). Synergistic activation of dendritic cells by combined toll-like receptor ligation induces superior ctl responses in vivo. Blood, 108(2), 544–550.

    CAS  PubMed  Google Scholar 

  • Werth, S., Urban-Klein, B., Dai, L., Hobel, S., Grzelinski, M., Bakowsky, U., et al. (2006). A low molecular weight fraction of polyethylenimine (pei) displays increased transfection efficiency of dna and sirna in fresh or lyophilized complexes. J Control Release, 112(2), 257–270.

    CAS  PubMed  Google Scholar 

  • Xu, H., Chen, T., Wang, H. Q., Ji, M. J., Zhu, X., & Wu, W. X. (2006). Prolongation of rat intestinal allograft survival by administration of donor interleukin-12 p35-silenced bone marrow-derived dendritic cells. Transplant Proc, 38(5), 1561–1563.

    Google Scholar 

  • Yamaguchi, N., Hiraoka, S., Mukai, T., Takeuchi, N., Zhou, X. Y., Ono, S., et al. (2004). Induction of tumor regression by administration of b7-ig fusion proteins: Mediation by type 2 cd8+ t cells and dependence on il-4 production. J Immunol, 172(3), 1347–1354.

    CAS  PubMed  Google Scholar 

  • Yang, Y., Huang, C. T., Huang, X., & Pardoll, D. M. (2004). Persistent toll-like receptor signals are required for reversal of regulatory t cell-mediated cd8 tolerance. Nat Immunol, 5(5), 508–515.

    CAS  PubMed  Google Scholar 

  • Yee, C. (2005). Adoptive t cell therapy: Addressing challenges in cancer immunotherapy. J Transl Med, 3(1), 17.

    PubMed  Google Scholar 

  • Yuan, D., Koh, C. Y., & Wilder, J. A. (1994). Interactions between b lymphocytes and nk cells. Faseb J, 8(13), 1012–1018.

    CAS  PubMed  Google Scholar 

  • Yuan, D., Wilder, J., Dang, T., Bennett, M., & Kumar, V. (1992). Activation of b lymphocytes by nk cells. Int Immunol, 4(12), 1373–1380.

    CAS  PubMed  Google Scholar 

  • Zanoni, I., Foti, M., Ricciardi-Castagnoli, P., & Granucci, F. (2005). Tlr-dependent activation stimuli associated with th1 responses confer nk cell stimulatory capacity to mouse dendritic cells. J Immunol, 175(1), 286–292.

    CAS  PubMed  Google Scholar 

  • Zeid, N. A., & Muller, H. K. (1993). S100 positive dendritic cells in human lung tumors associated with cell differentiation and enhanced survival. Pathology, 25(4), 338–343.

    CAS  PubMed  Google Scholar 

  • Zou, W. (2005). Immunosuppressive networks in the tumour environment and their therapeutic relevance. Nat Rev Cancer, 5(4), 263–274.

    CAS  PubMed  Google Scholar 

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Hamdy, S., Alshamsan, A., Samuel, J. (2009). Nanotechnology for Cancer Vaccine Delivery. In: de Villiers, M.M., Aramwit, P., Kwon, G.S. (eds) Nanotechnology in Drug Delivery. Biotechnology: Pharmaceutical Aspects, vol X. Springer, New York, NY. https://doi.org/10.1007/978-0-387-77668-2_17

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