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Controlled Release and Nanotechnology

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Nanotechnology in Drug Delivery

Part of the book series: Biotechnology: Pharmaceutical Aspects ((PHARMASP,volume X))

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References

  • Abo El Ola, S. M., R. Kotek, et al. (2004). “Studies on poly(trimethylene terephthalate) filaments containing silver.” J Biomater Sci Polym Ed 15(12): 1545–59.

    PubMed  Google Scholar 

  • Agnihotri, S. A., N. N. Mallikarjuna, et al. (2004). “Recent advances on chitosan-based micro- and nanoparticles in drug delivery.” J Control Release 100(1): 5–28.

    CAS  PubMed  Google Scholar 

  • Balogh, L., D. R. Swanson, et al. (2001). “Dendrimer-silver complexes and nanocomposites as antimicrobial agents.” Nano Lett 1(1): 18–21.

    CAS  Google Scholar 

  • Beyond Skin Science (2007). Corona, CA (March 20, 2007); http://www.beyondskinscience.com

  • Bhabak, K. P. and G. Mugesh (2007). “Synthesis, characterization, and antioxidant activity of some ebselen analogues.” Chem A Eur J 13(16): 4594–4601.

    Google Scholar 

  • Bhadra, D., S. Bhadra, et al. (2003). “A PEGylated dendritic nanoparticulate carrier of fluorouracil.” Int J Pharm 257: 111–124.

    CAS  PubMed  Google Scholar 

  • Bhattacharya, S. and A. Bajaj (2005). “Recent advances in lipid molecular design.” Curr Opin Chem Biol 9(6): 647–655.

    CAS  PubMed  Google Scholar 

  • Bontha, S., A. V. Kabanov, et al. (2006). “Polymer micelles with cross-linked ionic cores for delivery of anticancer drugs.” J Control Release 114(2): 163–74.

    CAS  PubMed  Google Scholar 

  • Borgia, S. L., Regehly, M., Sivaramakrishnan, R., Mehnert, W., Korting, H. C., Danker, K., Röder, B., Kramer, K. D. and Schäfer-Korting, M. (2005). “Lipid nanoparticles for skin penetration enhancement-correlation to drug localization within the particle matrix as determined by fluorescence and parelectric spectroscopy.” J Control Release, 110: 151–163.

    Google Scholar 

  • Brannon-Peppas, L. (1995). “Recent advances on the use of biodegradable microparticles and nanoparticles in controlled drug delivery.” Int J Pharm 116: 1–9.

    CAS  Google Scholar 

  • Brannon-Peppas, L. and J. O. Blanchette (2004). “Nanoparticle and targeted systems for cancer therapy.” Adv Drug Del Rev 56: 1649–1659.

    CAS  Google Scholar 

  • Brett, D. W. (2006). “A discussion of silver as an antimicrobial agent: alleviating the confusion.” Ostomy Wound Manage 52(1): 34–41.

    PubMed  Google Scholar 

  • Bromberg, L. E., D. K. Buxton, et al. (2001). “Novel periodontal drug delivery system for treatment of periodontitis.” J Control Release 71(3): 251–9.

    CAS  PubMed  Google Scholar 

  • Boutelet, K. and D. Candau (2006). Photoprotective/cosmetic compositions comprising sulfonic/hydrophobic amphiphilic polymers, USA, L' Oreal, Patent 7,045,120.

    Google Scholar 

  • Calvo, P., J. L. VilaJato, et al. (1996). “Comparative in vitro evaluation of several colloidal systems, nanoparticles, nanocapsules, and nanoemulsions, as ocular drug carriers.” J Pharm Sci 85(5): 530–536.

    CAS  PubMed  Google Scholar 

  • Caves, J. M. and E. L. Chaikof (2006). “The evolving impact of microfabrication and nanotechnology on stent design.” J Vasc Surg 44(6): 1363–1368.

    PubMed  Google Scholar 

  • Cengiz, E., Wissing, S. A., Müller, R. H. and Yazan, Y. (2006). Sunblocking efficiency of various ti)2-loaded solid lipid nanoparticle formulations. Int J Cosm Sci 28: 371–378.

    CAS  Google Scholar 

  • Chen, H., Chang, X., Du, D., Liu, W., Liu, J., Weng, T., Yang, Y., Xu, H. and Yang, X. (2006). Podophyllotoxin-loaded solid lipid nanoparticles for epidermal targeting. J Control Release, 110: 296–306.

    CAS  PubMed  Google Scholar 

  • D'Emanuele, A. and D. Attwood (2005). “Dendrimer-drug interactions.” Adv Drug Del Rev 57(15): 2147–2162.

    Google Scholar 

  • Devalapally, H., D. Shenoy, et al. (2007). “Poly(ethylene oxide)-modified poly(beta-amino ester) nanoparticles as a pH-sensitive system for tumor-targeted delivery of hydrophobic drugs: part 3. Therapeutic efficacy and safety studies in ovarian cancer xenograft model.” Cancer Chemo Pharmacol 59(4): 477–484.

    CAS  Google Scholar 

  • Duprey Cosmetics (2007). (March 10, 2007); St. Pete Beach, Fl.; http://www.dupreycosmetics.com/ nano_dulcine.html

  • Edelman, E. R., L. Brown, et al. (1987). “In vitro and in vivo kinetics of regulated drug release from polymer matrices by oscillating magnetic fields.” J Biomed Mater Res 21(3): 339–53.

    CAS  PubMed  Google Scholar 

  • Edelman, E. R., A. Fiorino, et al. (1992). “Mechanical deformation of polymer matrix controlled release devices modulates drug release.” J Biomed Mater Res 26(12): 1619–31.

    CAS  PubMed  Google Scholar 

  • Environmental Working Group (2006). Washington, DC (October 10, 2006); http://www.ewg.org/issues/cosmetics/20061010/table2.php

  • Fonseca, C., S. Simões, et al. (2002). “Paclitaxel-loaded PLGA nanoparticles: preparation, physiochemical characterization and in vitro anti-tumoral activity.” J Control Release 83: 273–286.

    CAS  PubMed  Google Scholar 

  • Fresta, M., G. Puglisi, et al. (1995). “Pefloxacine mesilate-loaded and ofloxacin-loaded polyethylcyanoacrylate nanoparticles- Characterization of the colloidal drug carrier formulations.” J Pharm Sci 84(7): 895–902.

    CAS  PubMed  Google Scholar 

  • Fu, J., X. Li, et al. (2002). “Encapsulation of phthalocyanines in biodegradable poly(sebacic anhydride) nanoparticles.” Langmuir 18(10): 3843–3847.

    CAS  Google Scholar 

  • Gaponik, N., I. L. Radtchenko, et al. (2004). “Luminescent polymer microcapsules addressable by a magnetic field.” Langmuir 20(4): 1449–52.

    CAS  PubMed  Google Scholar 

  • Georgakilas, V., K. Kordatos, et al. (2002). “Organic functionalization of carbon nanotubes.” J Am Chem Soc 124(5): 760–761.

    CAS  PubMed  Google Scholar 

  • Georgakilas, V., N. Tagmatarchis, et al. (2002). “Amino acid functionalization of water soluble carbon nanotubes.” Chem Communs 24: 3050–4051.

    Google Scholar 

  • Guo, Z. and P. Sadler (1999). “Metals in medicine.” Angewandte Chemie-International Edition 38(11): 1513–1531.

    Google Scholar 

  • Guzman, L. A., V. Labhasetwar, et al. (1996). “Local intraluminal infusion of biodegradable polymeric nanoparticles – A novel approach for prolonged drug delivery after balloon angioplasty.” Circulation 94(6): 1441–1448.

    CAS  PubMed  Google Scholar 

  • Handjani, R.-M. and Ribier, A. (2001). Compositions for the cosmetic and/or pharmaceutical treatment of the epidermis by topical application to the skin, and corresponding preparation process, USA, L' Oreal, Patent 6,203,802.

    Google Scholar 

  • Hansenne, I. and Rick, D. W. (2002). High SPF nontacky/nongreasy uv-photoprotecting compositions comprising particulates of MMA crosspolymers, USA, L' Oreal, Patent 6,432,389.

    Google Scholar 

  • Heller, J., J. Barr, et al. (2002). “Poly(ortho esters): synthesis, characterization, properties and uses.” Adv Drug Del Rev 54(7): 1015–1039.

    CAS  Google Scholar 

  • Hirsch, L. R., A. M. Gobin, et al. (2006). “Metal nanoshells.” Ann Biomed Eng 34(1): 15–22.

    PubMed  Google Scholar 

  • Horcajada, P., C. Marquez-Alvarez, et al. (2006). “Controlled release of ibuprofen from dealuminated faujasites ” Solid State Sciences 8(12): 1459–1465

    CAS  Google Scholar 

  • Horcajada, P., C. Serre, et al. (2006). “Metal-organic frameworks as efficient materials for drug delivery.” Angew Chem Int Ed Engl 45(36): 5974–8.

    CAS  PubMed  Google Scholar 

  • Hu, Y. X., J. Chang, et al. (2005). Preparation and evaluation of 5-FU/PLGA/gene nanoparticles. Asbm6: Advanced Biomaterials Vi. Zurich-Uetikon, Trans Tech Publications Ltd: 147–150.

    Google Scholar 

  • Huth, S., J. Lausier, et al. (2004). “Insights into the mechanism of magnetofection using PEI-based magnetofectins for gene transfer.” J Gene Med 6(8): 923–36.

    CAS  PubMed  Google Scholar 

  • Isab, A. A. and M. I. Wazeer (2007). “Synthesis and characterization of thiolate-Ag(I) complexes by solid-state and solution NMR and their antimicrobial activity.” Spectrochim Acta A Mol Biomol Spectrosc 66(2): 364–370.

    Google Scholar 

  • Jain, R. A. (2000). “The manufacturing techniques of various drug loaded biodegradable poly(lactide-co-glycolide) (PLGA) devices.” Biomaterials 21(23): 2475–2490.

    CAS  PubMed  Google Scholar 

  • Jee, J.-P., Lim, S.-J., Park, J.-S. and Kim, C.-K. (2006). “Stabilization of all-trans retinol by loading lipophilic antioxidants in solid lipid nanoparticles.” Eur J Pharm Biopharm, 63: 134–139.

    CAS  PubMed  Google Scholar 

  • Jenning, V., Gysler, A., Schäfer-Korting, M. and Gohla, S. H. (2000). “Vitamin A loaded solid lipid nanoparticles for topical use: Occlusive properties and drug targeting in the upper skin.” Eur J Pharm Biopharm, 49: 211–218.

    CAS  PubMed  Google Scholar 

  • Kam, N. W. and H. Dai (2005). “Carbon nanotubes as intracellular protein transporters: generally and biological functionality.” J Am Chem Soc 127(16): 6021–6026.

    CAS  PubMed  Google Scholar 

  • Karlov, A. V., I. A. Khlusov, et al. (2002). “Adhesion of Staphylococcus aureus to implants with different physicochemical characteristics.” Bull Exp Biol Med 134(3): 277–80.

    CAS  PubMed  Google Scholar 

  • Kost, J., R. Noecker, et al. (1985). “Magnetically controlled release systems: effect of polymer composition.” J Biomed Mater Res 19(8): 935–40.

    CAS  PubMed  Google Scholar 

  • Kost, J., J. Wolfrum, et al. (1987). “Magnetically enhanced insulin release in diabetic rats.” J Biomed Mater Res 21(12): 1367–73.

    CAS  PubMed  Google Scholar 

  • Kumar, R., S. Howdle, et al. (2005). “Polyamide/silver antimicrobials: effect of filler types on the silver ion release.” J Biomed Mater Res B Appl Biomater 75(2): 311–9.

    PubMed  Google Scholar 

  • Labhasetwar, V., C. X. Song, et al. (1998). “Arterial uptake of biodegradable nanoparticles: Effect of surface modifications.” J Pharm Sci 87(10): 1229–1234.

    CAS  PubMed  Google Scholar 

  • Lanza, G. M., X. Yu, et al. (2002). “Targeted antiproliferative drug delivery to vascular smooth muscle cells with a magnetic resonance imaging nanoparticle contrast agent implications for rational therapy of restenosis.” Circulation 106(22): 2842–2847.

    CAS  PubMed  Google Scholar 

  • Li, Y.-Y., X.-Z. Zhang, et al. (2006). “Novel stimuli-responsive micelle self-assembled from Y-shaped P(UA-Y-NIPAAm) copolymer for drug delivery.” Biomacromolecules 7(11): 2956–2960.

    CAS  PubMed  Google Scholar 

  • Lin, A. W., N. A. Lewinski, et al. (2005). “Optically tunable nanoparticle contrast agents for early cancer detection: model-based analysis of gold nanoshells.” J Biomed Opt 10(6): 064035.

    PubMed  Google Scholar 

  • Liu, J., Hu, W., Chen, H., Ni, Q., Xu, H. and Yang, X. (2007). “Isotretinoin-loaded solid lipid nanoparticles with skin targeting for topical delivery.” Int J Pharm, 328: 191–195.

    CAS  PubMed  Google Scholar 

  • Liu, M. J., K. Kono, et al. (2000). “Water-soluble dendritic unimolecular micelles: Their potential as drug delivery agents.” J Control Release 65(1–2): 121–131.

    CAS  PubMed  Google Scholar 

  • Lu, Z., J. Z. Bei, et al. (1999). “A method for the preparation of polymeric nanocapsules without stabilizer.” J Control Release 61(1–2): 107–112.

    CAS  PubMed  Google Scholar 

  • MacLachlan, M., I. Manners, et al. (2000). “New (inter)faces: Polymers and inorganic materials ” Adv Materials 12(9): 675–681.

    CAS  Google Scholar 

  • Mainardes, R. M. and L. P. Silva (2004). “Drug delivery systems: Past, present, and future.” Curr Drug Targets 5(5): 449–455.

    CAS  PubMed  Google Scholar 

  • Mitra, S., U. Gaur, et al. (2001). “Tumour targeted delivery of encapsulated dextran-doxorubicin conjugate using chitosan nanoparticles as carrier.” J Control Release 74: 317–323.

    CAS  PubMed  Google Scholar 

  • Muller, R. H., K. Mader, et al. (2000). “Solid lipid nanoparticles (SLN) for controlled drug delivery – a review of the state of the art.” Eur J Pharm Biopharm 50(1): 161–177.

    CAS  PubMed  Google Scholar 

  • Müller, R. H., Radtke, M. and Wissing, S. A. (2002). Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in cosmetic and dermatological preparations. Adv Drug Del Rev, 54: S131–S155.

    Google Scholar 

  • Nakayama, M., T. Okano, et al. (2006). “Molecular design of biodegradable polymeric micelles for temperature-responsive drug release.” J Control Release 115(1): 46–56.

    CAS  PubMed  Google Scholar 

  • Napoli, A., M. Valentini, et al. (2005). “Oxidation-responsive polymeric vesicles.” Nature Biomaterials 3(3): 183–189.

    Google Scholar 

  • Niwa, T., H. Takeuchi, et al. (1993). “Preparation of biodegradable nanospheres of water-soluble and insoluble drugs with D,L-lactide/glycolide copolymer by a novel spontaneous emulsification solvent diffusion method, and the drug release behavior.” J Control Release 25: 89–93.

    CAS  Google Scholar 

  • O'Reilly, R. K., C. J. Hawker, et al. (2006). “Cross-linked block copolymer micelles: functional nanostructures of great potential and versatility.” Chemical Society Reviews 35(11): 1068–1083.

    PubMed  Google Scholar 

  • Oh, K. T., T. K. Bronich, et al. (2006). “Block ionomer complexes as prospective nanocontainers for drug delivery.” J Control Release 115(1): 9–17.

    CAS  PubMed  Google Scholar 

  • Owens III, D. and N. Peppas (2006). “Integration of thermally responsive nanosphere hydrogels with gold nanoparticles for intelligent therapeutic applications.” Trans Soc Biomater 31: 150–151.

    Google Scholar 

  • Panyam, J., W.-Z. Zhou, et al. (2002). “Rapid endo-lysosomal escape of poly(D,L-lactide-co-glycolide) nanoparticles: implications for drug and gene delivery.” FASEB 16(10): 1217–1226.

    CAS  Google Scholar 

  • Pastorin, G., W. Wu, et al. (2006). “Double functionalization of carbon nanotubes for multimodal delivery.” Chem Commun 11: 1182–1184.

    Google Scholar 

  • Patton, J. N. and A. F. Palmer (2005). “Engineering temperature-sensitive hydrogel nanoparticles entrapping hemoglobin as a novel type of oxygen carrier.” Biomacromolecules 6(4): 2204–2212.

    CAS  PubMed  Google Scholar 

  • Plank, C., F. Scherer, et al. (2003). “Magnetofection: enhancing and targeting gene delivery with superparamagnetic nanoparticles and magnetic fields.” J Liposome Res 13(1): 29–32.

    CAS  PubMed  Google Scholar 

  • Plank, C., U. Schillinger, et al. (2003). “The magnetofection method: using magnetic force to enhance gene delivery.” Biol Chem 384(5): 737–47.

    CAS  PubMed  Google Scholar 

  • Potineni, A., D. M. Lynn, et al. (2003). “Poly(ethylene oxide)-modified poly(beta-amino ester) nanoparticles as a pH-sensitive biodegradable system for paclitaxel delivery.” J Control Release 86(2–3): 223–234.

    CAS  PubMed  Google Scholar 

  • Radwan, M. A. (1995). “In-vitro evaluation of polyisobutylcyanoacrylate nanoparticles as a controlled drug carrier for theophylline.” Drug Dev Ind Pharm 21(20): 2371–2375.

    CAS  Google Scholar 

  • Rehor, A., J. A. Hubbell, et al. (2005). “Oxidation-sensitive polymeric nanoparticles.” Langmuir 21(1): 411–417.

    CAS  PubMed  Google Scholar 

  • Rhim, J. W., S. I. Hong, et al. (2006). “Preparation and characterization of chitosan-based nanocomposite films with antimicrobial activity.” J Agric Food Chem 54(16): 5814–22.

    CAS  PubMed  Google Scholar 

  • Roskos, K. V., B. K. Fritzinger, et al. (1995). “Development of a drug-delivery system for the treatment of periodontal-disease based on bioerodible poly(ortho esters).” Biomaterials 16(4): 313–317.

    CAS  PubMed  Google Scholar 

  • Sajeesh, S. and C. P. Sharma (2005). “Novel pH responsive polymethacrylic acid-chitosan-polyethylene glycol nanoparticles for oral peptide delivery.” J Biomat Mater Res B: Appl Biomat 76B(2): 298–305.

    Google Scholar 

  • Sakurai, H., A. Katoh, et al. (2006). “Chemistry and biochemistry of insulin-mimetic vanadium and zinc complexes. Trial for treatment of diabetes mellitus.” Bull. Chem. Soc. Jpn. 79(11): 1645–1664

    CAS  Google Scholar 

  • Sambhy, V., M. M. MacBride, et al. (2006). “Silver bromide nanoparticle/polymer composites: dual action tunable antimicrobial materials.” J Am Chem Soc 128(30): 9798–808.

    CAS  PubMed  Google Scholar 

  • Sawant, R. M., J. P. Hurley, et al. (2006). ““SMART” drug delivery systems: double-targeted pH-responsive pharmaceutical nanocarriers.” Bioconjug Chem 17(4): 943–949.

    CAS  PubMed  Google Scholar 

  • Schierholz, J. M., L. J. Lucas, et al. (1998). “Efficacy of silver-coated medical devices.” J Hosp Infect 40(4): 257–62.

    CAS  PubMed  Google Scholar 

  • Schmaljohann, D. (2006). “Thermo- and pH-responsive polymers in drug delivery.” Adv Drug Del Rev 58(15): 1655–1670.

    CAS  Google Scholar 

  • Sershen, S. R., S. L. Westcott, et al. (2000). “Temperature-sensitive polymer-nanoshell composites for photothermally modulated drug delivery.” J Biomed Mater Res 51(3): 293–8.

    CAS  PubMed  Google Scholar 

  • Seymour, L. W., R. Duncan, et al. (1994). “Poly(ortho ester) matrices for controlled release of the antitumor agent 5-fluorouracil.” J Control Release 31: 201–206.

    CAS  Google Scholar 

  • Shenoy, D., S. Little, et al. (2005). “Poly(ethylene oxide)-modified poly(beta-amino ester) nanoparticles as a pH-sensitive system for tumor-targeted delivery of hydrophobic drugs. Part 1 In vitro evaluations.” Mol Pharmacy 2(5): 357–366.

    CAS  Google Scholar 

  • Shenoy, D., S. Little, et al. (2005). “Poly(ethylene oxide)-modified poly(beta-amino ester) nanoparticles as a pH-sensitive system for tumor-targeted delivery of hydrophobic drugs: Part 2. In vivo distribution and tumor localization studies.” Pharm Res 22(12): 2107–2114.

    CAS  PubMed  Google Scholar 

  • Shikata, F., H. Tokumitsu, et al. (2002). “In vitro cellular accumulation of gadolinium incorporated into chitosan nanoparticles designed for neutron-capture therapy of cancer.” Eur. J. Pharm Biopharm. 53: 57–63.

    CAS  PubMed  Google Scholar 

  • Simonnet, J.-T. and Richart, P. (2002). Nanocapsules based on dendritic polymers, USA, L' Oreal, Patent 6,379,683.

    Google Scholar 

  • Simonnet, J.-T., Richart, P. and Biatry, B. (2003). Nanocapsules based on poly(alkylene adipate), process for their preparation and cosmetic or dermatological compositions containing them, USA, L' Oreal, Patent 6,565,886.

    Google Scholar 

  • Singh, R., D. Pantarotto, et al. (2006). “Tissue biodistribution and blood clearance rates of intravenously administered carbon nanotube radiotracers.” PNAS 103(9): 3357–3362.

    CAS  PubMed  Google Scholar 

  • Smaihi, M., E. Gavilan, et al. (2004). “Colloidal functionalized calcined zeolite nanocrystals ” J Mater Chem 14(8): 1347–1351.

    Google Scholar 

  • Song, C. and Liu, S. (2005). “A new healthy sunscreen system for humans: Solid lipid nanoparticles as carrier for 3,4,5-trimethoxybenzoylchitin and the improvement by adding vitamin E.” Int J Bio Macromol, 36: 116–119.

    CAS  Google Scholar 

  • Soppimath, K. S. and T. M. Aminabhavi (2002). “Ethyl acetate as a dispersing solvent in the production of poly(DL-lactide-co-glycolide) microspheres: effect of process parameters and polymer type.” J Microencapsulation 19(3): 281–292.

    CAS  PubMed  Google Scholar 

  • Soppimath, K. S., T. M. Aminabhavi, et al. (2001). “Biodegradable polymeric nanoparticles as drug delivery devices.” J Controlled Release 70(1–2): 1–20.

    CAS  Google Scholar 

  • Soppimath, K. S., D. C.-W. Tan, et al. (2005). “pH-Triggered thermally responsive polymer core-shell nanoparticles for drug delivery.” Adv Mater 17(3): 318–323.

    CAS  Google Scholar 

  • Steinbrink, J., H. Wabnitz, et al. (2001). “Determining changes in NIR absorption using a layered model of the human head.” Phys Med Biol 46(3): 879–896.

    CAS  PubMed  Google Scholar 

  • Taha, E. I., Samy, A. M., Kassem, A. A. and Khan, M. A. (2005). Response surface methodology for the development of self-nanoemulsified drug delivery system (SNEDDS) of all-trans-retinol acetate. Pharm Dev Tech, 10: 363–370.

    CAS  Google Scholar 

  • Tirelli, N. (2006). “(Bio)responsive nanoparticles.” Curr Opin Colloidal & Interface Sci 11(4): 210–216.

    CAS  Google Scholar 

  • Tokumitsu, H., H. Ichikawa, et al. (1999). “Chitosan-gadopentetic acid complex nanoparticles for gadolinium neutron-capture therapy of cancer: Preparation by novel emulsion-droplet coalescence technique and characterization.” Pharm Res 16(12): 1830–1835.

    CAS  PubMed  Google Scholar 

  • Uhrich, K. E., S. M. Cannizzaro, et al. (1999). “Polymeric systems for controlled drug release.” Chem Rev 99(11): 3181–3198.

    CAS  PubMed  Google Scholar 

  • van Zutphen, S. and J. Reedijk (2005). “Targeting platinum anti-tumour drugs: Overview of strategies employed to reduce systemic toxicity.” Coordination Chem Rev 249(24): 2845–2853.

    Google Scholar 

  • Vaupel, P., F. Kallinowski, et al. (1989). “Blood flow, oxygen and nutrient supply and metabolic microenvironment of human tumors: a review.” Cancer Res 49(23): 6449–6465.

    CAS  PubMed  Google Scholar 

  • Verma, A. K., K. Sachin, et al. (2005). “Release kinetics from bio-polymeric nanoparticles encapsulating protein synthesis inhibitor - Cycloheximide, for possible therapeutic applications.” Curr Pharm Biotechnol 6(2): 121–130.

    CAS  PubMed  Google Scholar 

  • Wei, H., X.-Z. Zhang, et al. (2006). “Self-assembled thermo- and pH-responsive micelles of poly(10-undecenoic acid-b-N-isopropylacrylamide) for drug delivery.” J Control Release 116(3): 266–274.

    CAS  PubMed  Google Scholar 

  • Wike-Hooley, J. A., J. Haveman, et al. (1984). “The relevance of tumor pH to the treatment of malignant disease.” Radiother Oncol 2(4): 343–366.

    CAS  PubMed  Google Scholar 

  • Wissing, S. A. and Müller, R. H. (2003). “Cosmetic applications for solid lipid nanoparticles (SLN).” Int J Pharm, 254, 65–68.

    CAS  PubMed  Google Scholar 

  • Wojtowicz, H., K. Kloc, et al. (2004). “Azaanalogues of ebselen as antimicrobial and antiviral agents: synthesis and properties.” Farmaco 59(11): 863–8.

    CAS  PubMed  Google Scholar 

  • Wu, W., S. Wieckowski, et al. (2005). “Targeted delivery of amphotericin B to cells by using functionalized carbon nanotubes.” Angew. Chem. Int. Ed. 44(39): 6358–6362.

    CAS  Google Scholar 

  • Xu, P., E. A. Van Kirk, et al. (2006). “Anticancer Efficacies of Cisplatin-Releasing pH-Responsive Nanoparticles.” Biomacromolecules 7(3): 829–835.

    CAS  PubMed  Google Scholar 

  • Yoo, H. S., K. H. Lee, et al. (2000). “In vitro and in vivo anti-tumor activities of nanoparticles based on doxorubicin-PLGA conjugates.” J Control Release 68(3): 419–431.

    CAS  PubMed  Google Scholar 

  • Zhang, H., Y. Kim, et al. (2006). “Controlled release of paraquat from surface-modified zeolite Y.” Microporous and Mesoporous Materials 88(1–3): 312–318

    CAS  Google Scholar 

  • Zwiorek, K., J. Kloeckner, et al. (2004). “Gelatin nanoparticles as a new and simple gene delivery system.” J Pharm Pharmac Sci 7(4): 22–28.

    CAS  Google Scholar 

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Betancourt, T., Doiron, A., Homan, K.A., Brannon-Peppas, L. (2009). Controlled Release and Nanotechnology. In: de Villiers, M.M., Aramwit, P., Kwon, G.S. (eds) Nanotechnology in Drug Delivery. Biotechnology: Pharmaceutical Aspects, vol X. Springer, New York, NY. https://doi.org/10.1007/978-0-387-77668-2_10

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