Vitamin D Status and Cancer Incidence and Mortality

  • Edward Giovannucci
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 624)


The role of excessive sun exposure in increasing risk of skin cancers is well established. Less known, less established and more controversial is the potential role of sun exposure in reducing risk of several types of internal cancers. The hypothesis that sunlight may be beneficial against several types of cancer extends back almost seven decades. Initially, Peller and Stephenson observed higher rates of skin cancer, but lower rates of other malignancies in United States Navy personnel in the 1930s.1 Based on this observation, Peller and Stephenson hypothesized that acquiring skin cancer conferred immunity against other cancers. Several years later, Apperly observed an association between latitude and cancer mortality rate, which led him to state that “The presence of skin cancer is really an occasional accompaniment of a relative cancer immunity in some way related to the exposure to solar radiation”.2 However, no plausible mechanism was proffered and these observations were essentially ignored for about four decades. In 1980, Garland and colleagues hypothesized that the potential benefit of sun exposure was attributed to vitamin D.3 Initially, the hypothesis was centered on colon cancer,3 but later it was extended to breast cancer,4 ovarian cancer,5 prostate cancer,6,7 and to multiple cancer types.8


Prostate Cancer Prostate Cancer Risk Advanced Prostate Cancer Pancreatic Cancer Risk Nonmelanoma Skin Cancer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Landes Bioscience and Springer Science+Business Media 2008

Authors and Affiliations

  • Edward Giovannucci
    • 1
    • 2
    • 3
    • 4
  1. 1.Departments of Nutrition and EpidemiologyHarvard School of Public HealthUSA
  2. 2.Channing Laboratory Department of MedicineHarvard Medical SchoolUSA
  3. 3.Brigham and Women’s HospitalBostonUSA
  4. 4.Harvard School of Public Health and Brigham and Women’s HospitalBostonUSA

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