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Cytogenetics of Melanoma and Nonmelanoma Skin Cancer

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Book cover Sunlight, Vitamin D and Skin Cancer

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 624))

Abstract

Cytogenetic analysis of melanoma and nonmelanoma skin cancers has revealed recurrent aberrations, the frequency of which is reflective of malignant potential. Highly aberrant karyotypes are seen in melanoma, squamous cell carcinoma, solar keratosis and Merkel cell carcinoma with more stable karyotypes seen in basal cell carcinoma, keratoacanthoma, Bowen’s disease, dermatofibrosarcomaprotuberans and cutaneous lymphomas. Some aberrations were common amongst a number of skin cancer types including rearrangements and numerical abnormalities of chromosome 1, −3p, +3q, partial or entire trisomy 6, trisomy 7, +8q, −9p, +9q, partial or entire loss of chromosome 10, −17p, + 17q and partial or entire gain of chromosome 20. Combination of cytogenetic analysis with other molecular genetic techniques has enabled the identification of not only aberrant chromosomal regions, but also the genes that contribute to a malignant phenotype. This review provides a comprehensive summary of the pertinent cytogenetic aberrations associated with a variety of melanoma and nonmelanoma skin cancers.

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Authors and Affiliations

  1. Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas, USA

    Melanie A. Carless

  2. Genomics Research Centre, School of Health Science, Griffith University Gold Coast, PMB 50 Gold Coast Mail Centre, Bundall, QLD, Australia

    Lyn R. Griffiths

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  1. Melanie A. Carless
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  1. Clinic for Dermatology, Venerology and Allergology, The Saarland University Hospital, Homburg/Saar, Germany

    Jörg Reichrath

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Carless, M.A., Griffiths, L.R. (2008). Cytogenetics of Melanoma and Nonmelanoma Skin Cancer. In: Reichrath, J. (eds) Sunlight, Vitamin D and Skin Cancer. Advances in Experimental Medicine and Biology, vol 624. Springer, New York, NY. https://doi.org/10.1007/978-0-387-77574-6_18

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