Abstract
Chirality, meaning handedness, pervades much of modern science, from the physics of elementary particles to the chemistry of life. The amino acids and sugars from which the central molecules of life—proteins and nucleic acids—are constructed exhibit homochirality, which is expected to be a key biosignature in astrobiology. This article provides a brief review of molecular chirality and its significance for the detection of extant or extinct life on other worlds. Fundamental symmetry aspects are emphasized since these bring intrinsic physical properties of the universe to bear on the problem of the origin and role of homochirality in the living world.
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References
M. Avalos, R. Babiano, P. Cintas, J.L. Jiménez, J.C. Palacios, L.D. Barron, Chem. Rev. 98, 2391 (1998)
M. Avalos, R. Babiano, P. Cintas, J.L. Jiménez, J.C. Palacios, Orig. Life 34, 391 (2004a)
M. Avalos, R. Babiano, P. Cintas, J.L. Jiménez, J.C. Palacios, Tet. Asym. 15, 3171 (2004b)
V.A. Avetisov, V.I. Goldanskii, V.V. Kuz’min, Phys. Today, July, 33 (1991)
J.L. Bada, G.D. McDonald, Icarus 114, 139 (1995)
J. Bailey, A. Chryosostomou, J.H. Hough, T.M. Gledhill, A. McCall, S. Clark, F. Ménard, M. Tamura, Science 281, 672 (1998)
P. Ball, Nature 436, 1084 (2005)
L.D. Barron, J. Am. Chem. Soc. 108, 5539 (1986)
L.D. Barron, Chem. Phys. Lett. 135, 1 (1987)
L.D. Barron, Chem. Phys. Lett. 221, 311 (1994a)
L.D. Barron, Science 266, 1491 (1994b)
L.D. Barron, Nature 405, 895 (2000)
L.D. Barron, in Chirality in Natural and Applied Science, ed. by W.J. Lough, I.W. Wainer (Blackwell, Oxford, 2002), p. 53
L.D. Barron, Molecular Light Scattering and Optical Activity, 2nd edn (Cambridge University Press, Cambridge, 2004)
L.D. Barron, F. Zhu, L. Hecht, G.E. Tranter, N.W. Isaacs, J. Mol. Struct. 834, 7 (2007)
J.-P. Behr (ed.) The Lock and Key Principle (Wiley, New York, 1994)
V.B. Berestetskii, E.M. Lifshitz, L.P. Pitaevskii, Quantum Electrodynamics (Pergamon, Oxford, 1982)
W.A. Bonner, Top. Stereochem. 18, 1 (1988)
M.A. Bouchiat, C. Bouchiat, Rep. Prog. Phys. 60, 1351 (1997)
A. Brack, Adv. Space Res. 24, 417 (1999)
P. Cintas, Ang. Chem. Int. Ed. 41, 1139 (2002)
R.N. Compton, R.M. Pagni, Adv. At. Mol. Opt. Phys. 48, 219 (2002)
J.J.L.M. Cornelissen, A.E. Rowan, R.J.M. Nolte, N.A.J.M. Sommerdijk, Chem. Rev. 101, 4039 (2001)
J.R. Cronin, S. Pizzarello, Science 275, 951 (1997)
P. Curie, J. Phys. (Paris) 3, 393 (1894)
B.L. Feringa, R.A. van Delden, Angew. Chem. Int. Ed. 38, 3418 (1999)
N. Fujii, Orig. Life 32, 103 (2002)
K. Gottfried, V.F. Weisskopf, Concepts of Particle Physics, vol. 1 (Clarendon Press, Oxford, 1984)
M.M. Green, N.C. Peterson, T. Sato, A. Teramoto, R. Cook, S. Lifson, Science 268, 1860 (1995)
R.M. Hazen, T.R. Filley, G.A. Goodfriend, Proc. Natl. Acad. Sci. USA 98, 5487 (2001)
R.A. Hegstrom, D.W. Rein, P.G.H. Sandars, J. Chem. Phys. 73, 2329 (1980)
F.M. Jaeger, Optical Activity and High-Temperature Measurements (McGraw-Hill, New York, 1930)
G.F. Joyce, G.M. Visser, C.A.A. van Boeckel, J.H. van Boom, L.E. Orgel, J. van Westresen, Nature 310, 602 (1984)
Lord Kelvin, Baltimore Lectures (C.J. Clay & Sons, London, 1904)
L. Keszthelyi, Quart. Rev. Biophys. 28, 473 (1995)
M. Klussman, H. Iwamura, S.P. Mathew, D.H. Wells Jr., U. Pandya, A. Armstrong, D.G. Blackmond, Nature 441, 621 (2006)
D.K. Kondepudi, K. Asakura, Accs. Chem. Res. 34, 946 (2001)
R. Konno, H. Brückner, A. D’Aniello, G.H. Fisher, N. Fujii, H. Homma (eds.), D-Amino Acids: A New Frontier in Amino Acid and Protein Research – Practical Methods and Protocols (Nova Science Publishers, New York, 2007)
M. Lahav, I. Weissbuch, E. Shavit, C. Reiner, G.J. Nicholson, V. Schurig, Orig. Life 36, 151 (2006)
A.J. MacDermott, in Chirality in Natural and Applied Science, ed. by W.J. Lough, I.W. Wainer (Blackwell, Oxford, 2002), p. 23
S.F. Mason, Chem. Soc. Rev. 17, 347 (1988)
U.J. Meierhenrich, L. Nahon, C. Alcarez, J.H. Bredehöft, S.V. Hoffman, B. Barbier, A. Brack, Ang. Chem. Int. Ed. 44, 5630 (2005)
C.A. Orme, A. Noy, A. Wierzbicki, M.T. McBride, M. Grantham, H.H. Teng, P.M. Dove, J.J. DeYoreo, Nature 411, 775 (2001)
R.M. Pagni, R.N. Compton, Cryst. Growth Des. 2, 249 (2002)
L. Pasteur, Bull. Soc. Chim. France 41, 219 (1884)
R.H. Perry, C. Wu, M. Nefliu, R.G. Cooks, Chem. Commun., 2007, p. 1071
S. Pizzarello, Accs. Chem. Res. 39, 231 (2006)
S. Pizzarello, M. Zolensky, K.A. Turk, Geochim. Cosmochim. Acta 67, 1589 (2003)
J. Popp, M. Schmitt, J. Raman Spectrosc. 35, 429 (2004)
M. Quack, Ang. Chem. Int. Ed. 41, 4618 (2002)
G.L.J.A. Rikken, E. Raupach, Nature 405, 932 (2000)
I. Rubinstein, R. Eliash, G. Bolbach, I. Weissbuch, M. Lahav, Ang. Chem. Int. Ed. 46, 1 (2007)
A.M. Skelley, R.A. Mathies, J. Chromatogr. A1021, 191 (2003)
W.B. Sparks, J.H. Hough, L.E. Bergeron, Astrobiology 5, 737 (2005)
G.H. Wagnière, A. Meir, Chem. Phys. Lett. 93, 78 (1982)
R. Wesendrup, J.K. Laerdahl, R.N. Compton, P. Schwerdtfeger, J. Phys. Chem. A 107, 6668 (2003)
I. Weissbuch, L. Leiserowitz, M. Lahav, Top. Curr. Chem. 259, 123 (2005)
E. Westhof (ed.), Water and Biological Macromolecules (CRC, Boca Raton, 1993)
D.C.B. Whittet, Dust in the Galactic Environment (Institute of Physics Publishing, Bristol, 1992)
R.D. Wolstencroft, G.E. Tranter, D.D. Le Pevelen, IAU Symp. 213, 149 (2002)
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Barron, L. (2008). Chirality and Life. In: Botta, O., Bada, J.L., Gomez-Elvira, J., Javaux, E., Selsis, F., Summons, R. (eds) Strategies of Life Detection. Space Sciences Series of ISSI, vol 25. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-77516-6_13
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