Plasmalogens play important roles in mammalian brain (Lee, 1998; Nagan and Zoeller, 2001; Farooqui and Horrocks, 2001). Beside being a structural component of cellular membranes and a major reservoir for arachidonic and docosahexaenoic acids (AA and DHA), plasmalogens are also involved in transport of ions across plasma membranes (Gross, 1985), membrane fusion (Lohner, 1996), protection of cellular membranes against oxidative stress (Zoeller et al., 1988; Engelmann et al., 1994), and the efflux of cholesterol from cells mediated by high-density lipoprotein (HDL) (Fig. 5.1) (Mandel et al., 1998). Plasmalogens are also found in the nucleus, where they may be involved in cellular differentiation (Bichenkov and Ellingson, 1999; Albi et al., 2004). The occurrence of plasmalogens in the synaptic cleft suggests that these phospholipids not only play an important role in synaptogenesis, but may also be involved in vesicle formation during neurotransmitter release (Farooqui and Horrocks, 2001). Plasmalogens may also be important in membrane dynamics, allowing the formation of inverted hexagonal structures, a property that may not only contribute to membrane fusion property, but also be important in modulating the membrane fluidity and permeability (Lohner, 1996).
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(2008). Roles of Plasmalogens in Brain. In: Metabolism and Functions of Bioactive Ether Lipids in the Brain. Springer, New York, NY. https://doi.org/10.1007/978-0-387-77401-5_5
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