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Induction of Drug-Metabolizing Enzymes: Contrasting Roles in Detoxification and Bioactivation of Drugs and Xenobiotics

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Advances in Bioactivation Research

Part of the book series: Biotechnology: Pharmaceutical Aspects ((PHARMASP,volume IX))

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Notes

  1. 1.

    PXR, or pregnane X receptor, is also known as the pregnane activated receptor (PAR) or the steroid and xenobiotic receptor (SXR). The majority of recent literature uses the name PXR, and hence this convention is followed herein.

  2. 2.

    AREs are also known as electrophile responsive elements, or EpREs.

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  1. Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research & Development, Groton, CT 06340, USA

    Sharon L. Ripp

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    Adnan Elfarra

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Ripp, S.L. (2008). Induction of Drug-Metabolizing Enzymes: Contrasting Roles in Detoxification and Bioactivation of Drugs and Xenobiotics. In: Elfarra, A. (eds) Advances in Bioactivation Research. Biotechnology: Pharmaceutical Aspects, vol IX. Springer, New York, NY. https://doi.org/10.1007/978-0-387-77300-1_4

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