Case study on survival analysis:prediction of secondary cardiovascular events

  • E.W. Steyerberg
Part of the Statistics for Biology and Health book series (SBH)


Survival is an important long-term outcome in prognostic research, including medical areas such as cardiovascular disease and oncology. We consider a model for the occurrence of vascular events in patients with symptomatic cardiovascular disease. Patient data were from the second manifestations of arterial disease (SMART) study. We go through the seven steps of the checklist for developing valid prediction models, as presented in Part II. The final model looks promising, but needs external validation to prove its actual value. The data set and R code is made available at the book's Web site.


Abdominal Aortic Aneurysm Peripheral Arterial Disease Blood Pressure Measurement Abdominal Aortic Aneurysm Intima Media Thickness 
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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • E.W. Steyerberg
    • 1
  1. 1.Department of Public HealthErasmus MCRotterdamThe Netherlands

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