Adrenocortical Cancer in Children

  • Carlos Rodriguez-GalindoEmail author
  • Gerard P. Zambetti
  • Raul C. Ribeiro


Adrenocortical cancer (ACC) is a rare but aggressive childhood endocrine neoplasm. Its incidence in children is extremely low (only 0.2% of pediatric cancers) [1], and most pediatric oncologists see few cases or none. Little is known about this malignancy and most available information has been learned from its more frequent adult counterpart. In recent years, an international registry has provided insight into the clinical characteristics and relevant management issues regarding pediatric ACC and tumor tissue for biological studies. These studies have resulted in the discovery of a novel mechanism of tumorigenesis [2], the gift to science by one of the rarest childhood cancers.


Congenital Adrenal Hyperplasia TP53 Mutation Adrenocortical Carcinoma Carney Complex Germline TP53 Mutation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Carlos Rodriguez-Galindo
    • 1
    Email author
  • Gerard P. Zambetti
    • 2
  • Raul C. Ribeiro
    • 3
  1. 1.Department of Pediatric OncologyDana-Farber Cancer Institute and Children’s HospitalBostonUSA
  2. 2.Department of BiochemistrySt. Jude Children’s Research HospitalMemphisUSA
  3. 3.Department of OncologySt. Jude Children’s Research HospitalMemphisUSA

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