Surgery for Adrenocortical Carcinoma

  • James T. BroomeEmail author
  • Barbra S. Miller
  • Paul G. Gauger
  • Gerard M. Doherty


Surgery is the mainstay of therapy for adrenocortical carcinoma (ACC). It is thought that the first technically successful resection of an ACC was performed in 1889 by Thornton [1] (see Thompson history). Although reported as a sarcoma, it is likely this was an ACC based on the description of size (>20 pounds), accompanying hirsutism, and recurrence of disease with death 2 years later.


Adrenal Gland Inferior Vena Cava Superior Mesenteric Artery Tumor Thrombus Laparoscopic Adrenalectomy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    Thornton JK (1890) Abdominal nephrectomy for large sarcoma of the left suprarenal capsule: recovery. Trans Clin Soc Lond 23:150–153Google Scholar
  2. 2.
    Mayo CH (1927) Paroxysmal hypertension with tumour of retroperitoneal nerve. JAMA 89:1047–1050Google Scholar
  3. 3.
    von Langenbuch C (1882) Ein Fall von Exstirpation der Gallenblase. Berlin Klin Wochenschr 19:725–727Google Scholar
  4. 4.
    Wellbourn RB (1990) The history of endocrine surgery. Praeger, London, p 151 [Quoted]Google Scholar
  5. 5.
    Young HH (1936) Technique for simultaneous exposure and operation on the adrenals. Surg Gynaecol Obstet 63:179–188Google Scholar
  6. 6.
    Gagner M et al (1992) Laparoscopic adrenalectomy in Cushing’s syndrome and pheochromocytoma [letter]. N Engl J Med 327:1033CrossRefPubMedGoogle Scholar
  7. 7.
    Gagner M et al (1993) Early experience with laparoscopic approach for adrenalectomy. Surgery 114:1120–1125PubMedGoogle Scholar
  8. 8.
    Bilimoria KY et al (2008) Adrenocortical carcinoma in the United States: treatment utilization and prognostic factors. Cancer 1/113(11):3130–3136CrossRefGoogle Scholar
  9. 9.
    National Cancer Institute Cancer Center Programs.
  10. 10.
    Kendrick ML et al (2001) Adrenocortical carcinoma – surgical progress or status quo? Arch Surg 136:543–549CrossRefPubMedGoogle Scholar
  11. 11.
    Vassiolopoulou-Sellin R, Schultz PN (2001) Adrenocortical carcinoma – clinical outcome at the end of the 20th century. Cancer 92(5):1113–1121CrossRefGoogle Scholar
  12. 12.
    Doherty GM et al (1990 Dec) Time to recovery of the hypothalamic-pituitary-adrenal axis after curative resection of adrenal tumors in patients with Cushing’s syndrome. Surgery 108(6):1085–1090PubMedGoogle Scholar
  13. 13.
    Fassnacht M et al (2009) Limited prognostic value of the 2004 international union against cancer staging classification for adrenocortical carcinoma – proposal for a revised TNM classification. Cancer 115(2):243–250CrossRefPubMedGoogle Scholar
  14. 14.
    Paton BL et al (2006 Dec) Outcomes of adrenal cortical carcinoma in the United States. Surgery 140(6):914–920 [discussion 919–920]CrossRefPubMedGoogle Scholar
  15. 15.
    Kendrick ML et al (2001 May) Adrenocortical carcinoma: surgical progress or status quo? Arch Surg 136(5):543–549CrossRefPubMedGoogle Scholar
  16. 16.
    Dackiw AP et al (2001 Jul) Adrenal cortical carcinoma. World J Surg 25(7):914–926CrossRefPubMedGoogle Scholar
  17. 17.
    Icard P et al (2001) Adrenocortical carcinomas: surgical trends and results of a 253-patient series from the French association of endocrine surgeons study group. World J Surg 25:891–897CrossRefPubMedGoogle Scholar
  18. 18.
    Schulick RD, Brennan MF (1999) Long-term survival after complete resection and repeat resection in patients with adrenocortical carcinoma. Ann Surg Oncol 6(8):719–726CrossRefPubMedGoogle Scholar
  19. 19.
    Bellantone R et al (1997 Dec) Role of reoperation in recurrence of adrenal cortical carcinoma: results from 188 cases collected in the Italian National Registry for Adrenal Cortical Carcinoma. Surgery 122(6):1212–1218CrossRefPubMedGoogle Scholar
  20. 20.
    Schteingart DE et al (2005) Management of patients with adrenal cancer: recommendations of an international consensus conference. Endoc Relat Cancer 12:667–680CrossRefGoogle Scholar
  21. 21.
    Cianco G et al (2000) The use of liver transplant techniques to aid in the surgical management of urological tumors. J Urol 164:665–672CrossRefGoogle Scholar
  22. 22.
    Ekici S, Ciancio G (2004) Surgical management of large adrenal masses with or without thrombus extending into the inferior vena cava. J Urol 172:2340–2343CrossRefPubMedGoogle Scholar
  23. 23.
    Perry MO (2002) Injuries to the vena cava figure 25–4 and 25–8 pages 319 and 321. In: Thal ER et al (eds) Operative trauma management: an atlas, 2nd edn. McGraw Hill, Columbus, OHGoogle Scholar
  24. 24.
    Pachter HL (2002) Perihepatic venous injuries figure 20–5a, 5b, 5c page 253. In: Thal ER et al (eds) Operative trauma management: an atlas, 2nd edn. McGraw Hill, Columbus, OHGoogle Scholar
  25. 25.
    Schrock T et al (1968 May) Management of blunt trauma to the liver and hepatic veins. Arch Surg 96(5):698–704PubMedGoogle Scholar
  26. 26.
    Gonzalez RJ et al (2005) Laparoscopic resection of adrenal cortical carcinoma: a cautionary note. Surgery138:1078–1086CrossRefPubMedGoogle Scholar
  27. 27.
    Zafar SS, Abaza R (2008) Robot-assisted laparoscopic adrenalectomy for adrenocortical carcinoma: initial report and review of the literature. J Endourol 22(5):985–989CrossRefPubMedGoogle Scholar
  28. 28.
    Henry JF et al (2002) Results of laparoscopic adrenalectomy for large and potentially malignant tumors. World J Surg 26:1043–1047CrossRefPubMedGoogle Scholar
  29. 29.
    Miller BS et al (2010) Laparoscopic resection is inappropriate in patients with known or suspected adrenocortical carcinoma. World J Surg 34(6):1380–1385CrossRefPubMedGoogle Scholar
  30. 30.
    Castillo OA et al (2008) Laparoscopic adrenalectomy for adrenal masses: does size matter? Urology 71:1138–1141CrossRefPubMedGoogle Scholar
  31. 31.
    Palazzo FF et al (2006) Long-term outcome following laparoscopic adrenalectomy for large solid adrenal cortex tumors. World J Surg 30:893–898CrossRefPubMedGoogle Scholar
  32. 32.
    Guerrieri M et al (2008) The learning curve in laparoscopic adrenalectomy. J Endocrinol Invest 31:531–536PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • James T. Broome
    • 1
    Email author
  • Barbra S. Miller
    • 2
  • Paul G. Gauger
    • 2
  • Gerard M. Doherty
    • 3
  1. 1.Vanderbilt Endocrine Surgery CenterVanderbilt UniversityNashvilleUSA
  2. 2.Department of SurgeryUniversity of Michigan Health System, University of MichiganAnn ArborUSA
  3. 3.Department of SurgeryUniversity of Michigan Health System, The University of MichiganAnn ArborUSA

Personalised recommendations