The Insulin-Like Growth Factor System in Adrenocortical Growth Control and Carcinogenesis

  • Christian Fottner
  • Ina M. Niederle
  • Matthias M. WeberEmail author


In recent years there has been growing evidence for a central role of the insulin-like growth factor (IGF) system in tumorigenesis and tumor growth. IGFs inhibit apoptosis, induce transformation, and promote tumor growth in many types of malignancies. Previously published data indicate that the IGF system is a major regulator of normal adrenocortical growth and development.


Adrenocortical Cell IGFBP2 Level Adrenocortical Tumor IGFBP2 Expression IGF2 mRNA 
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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Christian Fottner
    • 1
  • Ina M. Niederle
    • 1
  • Matthias M. Weber
    • 1
    Email author
  1. 1.Schwerpunkt Endokrinologie und Stoffwechselerkrankungen, I. Medizinische Klinik und Poliklinik, UniversitätsmedizinJohannes Gutenberg Universität MainzMainzGermany

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