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Role of Chemokines and Chemokine Receptors in Diseases of Ageing

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Immunosenescence

Part of the book series: Medical Intelligence Unit ((MIUN))

Abstract

Chemokines play an important role in orchestrating leukocyte recruitment and activation during inflammation. Given the ubiquity of chemokines involved in inflammatory tissue destruction, it is not surprising that they contribute to numerous human pathologies. Epidemiological studies have suggested that chronic low-grade inflammation is related to several diseases of ageing with an inflammatory pathogenesis (such as atherosclerosis, type 2 diabetes, osteoarthritis and Alzheimer’s disease) and to increased mortality risk. In this chapter, we will briefly review the properties of chemokines and their receptors and highlight the roles of these chemoattractants in the above selected diseases of ageing.

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Authors and Affiliations

  1. Dipartimento di Medicina Interna e Gastroenterologia, University of Bologna, Bologna, Italy

    Adriana Rita Mariani & Andrea Facchini

  2. Laboratorio di Immunologia e Genetica, Istituto di Ricerca Codivilla-Putti, IOR, Via di Barbiano 1/10, 40136, Bologna, Italy

    Erminia Mariani

Authors
  1. Erminia Mariani
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  2. Adriana Rita Mariani
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  3. Andrea Facchini
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© 2007 Landes Bioscience and Springer Science+Business Media

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Mariani, E., Mariani, A.R., Facchini, A. (2007). Role of Chemokines and Chemokine Receptors in Diseases of Ageing. In: Immunosenescence. Medical Intelligence Unit. Springer, New York, NY. https://doi.org/10.1007/978-0-387-76842-7_9

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