The reelin gene maps to mouse chromosome 5 and human chromosome 7q22 (DeSilva et al., 1997; Royaux et al., 1997). The mouse reelin gene has a large size, about 450kb, principally due to the presence of some very large introns. It is composed of 65 exons, 51 of which encode the eight reelin repeats. At the 3′-terminal portion of the gene, alternative splicing involves the inclusion of a hexanucleotide AGTAAG encoding amino acids Val-Ser, which create a potential phosphorylation site. This sequence is flanked by two introns and considered a bona fide exon (exon 64) (Royaux et al., 1997). The hexanucleotide sequence is evolutionarily conserved, because it is observed in the same relative location in the turtle and lizard cDNA, while the similar sequence AATAAG is present in chick (Lambert de Rouvrait et al., 1999). An alternative, polyadenylated product corresponds to the alternative exon 63a, expressed in the embryonic mouse brain, that codes for a truncated protein lacking the C-terminal region. This alternative mRNA represents between 10 and 25% of total reelin message in the embryonic mouse brain and is most abundant in Cajal-Retzius neurons of the cerebral cortex and hippocampus and in granule cells of the cerebellum; highly similar sequences are also found in human and rat. While reelin mRNA containing the microexon 64 is the major form in the brain of mouse, rat, man, turtle, and lizard, reelin transcripts in liver and kidney lack the hexanucleotide (Lambert de Rouvrait et al., 1999).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Abraham, H., and Meyer, G. (2003). Reelin-expressing neurons in the postnatal and adult human hippocampal formation. Hippocampus 13: 715-727.
Abraham, H., Perez-Garcia, C. G., and Meyer, G. (2004). p73 and reelin in Cajal-Retzius cells of the developing human hippocampal formation. Cerebral Cortex 14:484-495.
Alcantara, S., Ruiz, M., D’Arcangelo, G., Ezan, F., de Lecea, L., Curran, T., Sotelo, C., and Soriano E. (1998). Regional and cellular patterns of reelin mRNA expression in the forebrain of the developing and adult mouse. J. Neurosci. 18:7779-7799.
Bar, I., Lambert de Rouvroit, C., and Goffinet, A. M. (2000). The evolution of cortical develop-ment. An hypothesis based on the role of the reelin signaling pathway. Trends Neurosci. 23:633-638.
Bar, I., Tissir, F., Lambert de Rouvroit, C., De Backer, O., and Goffinet, A. M. (2003). The gene encoding disabled-1 (DAB1), the intracellular adaptor of the reelin pathway, reveals unusual complexity in human and mouse. J. Biol. Chem. 278:5802-5812.
Beffert, U., Weeber, E. J., Durudas, A., Qiu, S., Masiulis, I., Sweatt, J. D., Li, W. P., Adelmann, G., Frotscher, M., Hammer, R. E., and Herz, J. (2005). Modulation of synaptic plasticity and memory by reelin involves differential splicing of the lipoprotein receptor Apoer2. Neuron 47:567-579.
Beffert, U., Durudas, A., Weeber, E. J., Stolt, P. C., Giehl, K. M., Sweatt, J. D., Hammer, R. E., and Herz, J. (2006). Functional dissection of reelin signaling by site-directed disruption of disabled-1 adaptor binding to apolipoprotein E receptor 2: distinct roles in development and synaptic plasticity. J. Neurosci. 26:2041-2052.
Bernier, B., Bar, I., Pieau, C., Lambert de Rouvroit, C., and Goffinet, A. M. (1999). Reelin mRNA expression during embryonic brain development in the turtle Emys orbicularis. J. Comp. Neurol. 413:463-479.
Bernier, B., Bar, I., D’Arcangelo, G., Curran, T., and Goffinet, A. M. (2000). Reelin mRNA expression during embryonic brain development in the chick. J. Comp. Neurol. 422:448-463.
Bielle, F., Griveau, A., Narboux-Neme, N., Vigneau, S., Sigrist, M., Arber, S., Wassef, M., and Pierani, A. (2005). Multiple origins of Cajal-Retzius cells at the borders of the developing pallium. Nature Neurosci. 8:1002-1012.
Botella-Lopez, A., Burgaya, F., Gavin, R., Garcia-Ayllon, M. S., Gomez-Tortosa, E., Pena-Casanova, J., Urena, J. M., Del Rio, J. A., Blesa, R., Soriano, E., and Saez-Valero, J. (2006). Reelin expression and glycosylation patterns are altered in Alzheimer’s disease. Proc. Natl. Acad. Sci. USA 103:5573-5578.
Braak, H., and Braak, E. (1992). The human entorhinal cortex: normal morphology and lamina-specific pathology in various diseases. Neurosci. Res. 15:6-31.
Cabrera-Socorro, A., Hernandez-Acosta, N. C., Gonzalez-Gomez, M., and Meyer, G. (2007). Comparative aspects of p73 and reelin expression in Cajal-Retzius cells and the cortical hem in lizard, mouse and human. Brain Res. 1132:59-70.
Ceranik, K., Deng, J., Heimrich, B., Lubke, J., Zhao, S., Forster, E., and Frotscher, M. (1999). Hippocampal Cajal-Retzius cells project to the entorhinal cortex: retrograde tracing and intra-cellular labelling studies. Eur. J. Neurosci. 11:4278-4290.
Chen, M. L., Chen, S. Y., Huang, C. H., and Chen, C. H. (2002). Identification of a single nucle-otide polymorphism at the 5 promoter region of human reelin gene and association study with schizophrenia. Mol. Psychiatry 7:447-448.
Chen, Y., Sharma, R. P., Costa, R. H., Costa, E., and Grayson, D. R. (2002). On the epigenetic regulation of the human reelin promoter. Nucleic Acids Res. 30:2930-2939.
Chen, Y., Beffert, U., Ertunc, M., Tang, T. S., Kavalali, E. T., Bezprozvanny, I., and Herz, J. (2005). Reelin modulates NMDA receptor activity in cortical neurons. J. Neurosci. 25:8209-8216.
Chin, J., Massaro, C. M., Palop, J. J., Thwin, M. T., Yu, G. Q., Bien-Ly, N., Bender, A., and Mucke, L. (2007). Reelin depletion in the entorhinal cortex of human amyloid precursor protein trans-genic mice and humans with Alzheimer’s disease. J. Neurosci. 27:2727-2733.
Costagli, A., Kapsimali, M., Wilson, S. W., and Mione, M. (2002). Conserved and divergent patterns of reelin expression in the zebrafish central nervous system. J. Comp. Neurol. 450:73-93.
Costagli, A., Felice, B., Guffanti, A., Wilson, S. W., and Mione, M. (2006). Identification of alter-natively spliced dab1 isoforms in zebrafish. Dev.Genes Evol. 216:291-299.
D’Arcangelo G., Miao, G. G., Chen, S. C., Soares, H. D., Morgan, J. I., and Curran, T. (1995). A protein related to extracellular matrix proteins deleted in the mouse mutant reeler. Nature 374:719-723.
D’Arcangelo, G., Nakajima, K., Miyata, T., Ogawa, M., Mikoshiba, K., and Curran, T. (1997). Reelin is a secreted glycoprotein recognized by the CR-50 monoclonal antibody. J. Neurosci. 17:23-31.
de Bergeyck, V., Naerhuyzen, B., Goffinet, A. M., and Lambert de Rouvroit, C. (1998). A panel of monoclonal antibodies against reelin, the extracellular matrix protein defective in reeler mutant mice. J. Neurosci. Methods 82:17-24.
Deguchi, K., Inoue, K., Avila, W. E., Lopez-Terrada, D., Antalffy, B. A., Quattrocchi, C. C., Sheldon, M., Mikoshiba, K., D’Arcangelo, G., and Armstrong, D. L. (2003). Reelin and disa-bled-1 expression in developing and mature human cortical neurons. J. Neuropathol. Exp. Neurol. 62:676-684.
Derer, P., and Derer, M. (1990). Cajal-Retzius cell ontogenesis and death in mouse brain visual-ized with horseradish peroxidase and electron microscopy. Neuroscience 36:839-856.
Derer, P., Derer, M., and Goffinet, A. (2001). Axonal secretion of reelin by Cajal-Retzius cells: evidence from comparison of normal and Reln(Orl) mutant mice. J. Comp. Neurol. 440:136-143.
DeSilva, U., D’Arcangelo, G., Braden, V. V., Chen, J., Miao, G. G., Curran, T., and Green, E. D. (1997). The human reelin gene: isolation, sequencing, and mapping on chromosome 7. Genome Res. 199:157-164.
Drakew, A., Frotscher, M., Deller, T., Ogawa, M., and Heimrich, B. (1998). Developmental distri-bution of a reeler gene-related antigen in the rat hippocampal formation visualized by CR-50 immunocytochemistry. Neuroscience 82:1079-1086.
Eastwood, S. L., and Harrison, P. J. (2006). Cellular basis of reduced cortical reelin expression in schizophrenia. Am. J. Psychiatry 163:540-542.
Fatemi, S. H., Emamian, E. S., Kist, D., Sidwell, R. W., Nakajima, K., Akhter, P., Shier, A., Sheikh, S., and Bailey, K. (1999). Defective corticogenesis and reduction in reelin immunoreactivity in cortex and hippocampus of prenatally infected neonatal mice. Mol. Psychiatry 4:145-154.
Fatemi, S. H., Earle, J. A., and McMenomy, T. (2000). Reduction in reelin immunoreactivity in hippocampus of subjects with schizophrenia, bipolar disorder and major depression. Mol. Psychiatry 5:654-663.
Gertler, F. B., Bennett, R. L., Clark, M. J., and Hoffmann, F. M. (1989). Drosophila abl tyrosine kinase in embryonic CNS axons: a role in axonogenesis is revealed through dosage-sensitive interactions with disabled. Cell 58:103-113.
Goffinet, A. M., Bar, I., Bernier, B., Trujillo, C., Raynaud, A., and Meyer, G. (1999). Reelin expression during embryonic brain development in lacertilian lizards. J. Comp. Neurol. 414:533-550.
Gomez-Isla, T., Price, J. L., McKeel, D. W., Jr., Morris, J. C., Growdon, J. H., and Hyman, B. T. (1996). Profound loss of layer II entorhinal cortex neurons occurs in very mild Alzheimer’s disease. J. Neurosci. 16:4491-4500.
Hevner, R. F., Neogi, T., Englund, C., Daza, R. A., and Fink, A. (2003). Cajal-Retzius cells in the mouse: transcription factors, neurotransmitters, and birthdays suggest a pallial origin. Brain Res. Dev. Brain Res. 141:39-53.
Hiesberger, T., Trommsdorff, M., Howell, B. W., Goffinet, A., Mumby, M. C., Cooper, J. A., and Herz, J. (1999). Direct binding of reelin to VLDL receptor and ApoE receptor 2 induces tyro-sine phosphorylation of disabled-1 and modulates tau phosphorylation. Neuron 24:481-489.
Howell, B. W., Herrick, T. M., and Cooper, J. A. (1999a). Reelin-induced tryosine phosphorylation of disabled 1 during neuronal positioning. Genes Dev. 13:643-648.
Howell, B. W., Lanier, L. M., Frank, R., Gertler, F. B., and Cooper, J. A. (1999b). The disabled 1 phosphotyrosine-binding domain binds to the internalization signals of transmembrane glyco-proteins and to phospholipids. Mol. Cell Biol.19:5179-5188.
Jellinger, K., Braak, H., Braak, E., and Fischer, P. (1991). Alzheimer lesions in the entorhinal region and isocortex in Parkinson’s and Alzheimer’s diseases. Ann. N.Y. Acad. Sci. 640:203-209.
Jossin, Y., Ignatova, N., Hiesberger, T., Herz, J., Lambert de Rouvroit, C., and Goffinet, A. M. (2004). The central fragment of reelin, generated by proteolytic processing in vivo, is critical to its function during cortical plate development. J. Neurosci. 24:514-521.
Keshvara, L., Benhayon, D., Magdaleno, S., and Curran, T. (2001). Identification of reelin-induced sites of tyrosyl phosphorylation on disabled 1. J. Biol. Chem. 276:16008-16014.
Lambert de Rouvroit, C., and Goffinet, A. M. (1998). The reeler mouse as a model of brain devel-opment. Adv. Anat. Embryol.Cell Biol. 50:1-106.
Lambert de Rouvroit, C., Bernier, B., Royaux, I., de Bergeyck, V., and Goffinet, A. M. (1999). Evolutionarily conserved, alternative splicing of reelin during brain development. Exp. Neurol. 156:229-238.
Luque, J. M., Morante-Oria, J., and Fairen, A. (2003). Localization of ApoER2, VLDLR and Dab1 in radial glia: groundwork for a new model of reelin action during cortical development. Brain Res. Dev. Brain Res. 140:195-203.
Martinez-Cerdeno, V., and Clasca, F. (2002). Reelin immunoreactivity in the adult neocortex: a com-parative study in rodents, carnivores, and non-human primates. Brain Res. Bull. 57:485-488.
Martinez-Cerdeno, V., Galazo, M. J., Cavada, C., and Clasca, F. (2002). Reelin immunoreactivity in the adult primate brain: intracellular localization in projecting and local circuit neurons of the cerebral cortex, hippocampus and subcortical regions. Cerebral Cortex 12:1298-1311.
Martinez-Cerdeno, V., Galazo, M. J., and Clasca, F. (2003). Reelin-immunoreactive neurons, axons, and neuropil in the adult ferret brain: evidence for axonal secretion of reelin in long axonal pathways. J. Comp. Neurol. 463:92-116.
Meyer, G. (2001). Human neocortical development: the importance of embryonic and early fetal events. Neuroscientist 7:303-314.
Meyer, G. (2007). Genetic control of neuronal migrations in human cortical development. Adv. Anat. Embryol. Cell Biol.189:1-111.
Meyer, G., and Goffinet, A. M. (1998). Prenatal development of reelin-immunoreactive neurons in the human neocortex. J. Comp. Neurol. 397:29-40.
Meyer, G., and González-Hernández, T. (1993). Developmental changes in layer I of the human neocortex during prenatal life: a DiI-tracing and AChE and NADPH-d histochemistry study. J. Comp. Neurol. 338:317-336.
Meyer, G., and Wahle, P. (1999). The paleocortical ventricle is the origin of reelin-expressing neurons in the marginal zone of the foetal human neocortex. Eur. J. Neurosci. 11:3937-3944.
Meyer, G., Soria, J. M., Martinez-Galan, J. R., Martin-Clemente, B., and Fairen, A. (1998). Different origins and developmental histories of transient neurons in the marginal zone of the fetal and neonatal rat cortex. J. Comp. Neurol. 397:493-518.
Meyer, G., Goffinet, A. M., and Fairen, A. (1999). What is a Cajal-Retzius cell? A reassessment of a classical cell type based on recent observations in the developing neocortex. Cerebral Cortex 9:765-775.
Meyer, G., Pérez-García, C. G., Abraham, H., and Caput, D. (2002). Expression of p73 and reelin in the developing human cortex. J.Neurosci. 22:4973-4986.
Meyer, G., de Rouvroit, C. L., Goffinet, A. M., and Wahle, P. (2003). Disabled-1 mRNA and pro-tein expression in developing human cortex. Eur. J. Neurosci. 17:517-525.
Meyer, G., Cabrera-Socorro, A., Pérez-García, C. G., Martínez-Millán, L., Walker, N., and Caput, D. (2004). Developmental roles of p73 in Cajal-Retzius cells and cortical patterning. J. Neurosci. 24:9878-9887.
Nieuwenhuys, R., and Meek, J. (1990). The telencephalon of actinopterygian fishes. In Jones, G. G., and Peters, A. (Eds.), Cerebral Cortex, Vol. 8A. Plenum Press, New York, pp.31-73.
Ogawa, M., Miyata, T., Nakajima, K., Yagyu, K., Seike, M., Ikenaka, K., Yamamoto, H., and Mikoshiba, K. (1995). The reeler gene-associated antigen on Cajal-Retzius neurons is a crucial molecule for laminar organization of cortical neurons. Neuron 14:899-912.
Pappas, G. D., Kriho, V., and Pesold, C. (2001). Reelin in the extracellular matrix and dendritic spines of the cortex and hippocampus: a comparison between wild type and heterozygous reeler mice by immunoelectron microscopy. J. Neurocytol. 30:413-425.
Pérez-Costas, E., Melendez-Ferro, M., Santos, Y., Anadon, R., Rodicio, M. C., and Caruncho, H. J. (2002). Reelin immunoreactivity in the larval sea lamprey brain. J. Chem. Neuroanat. 23:211-221.
Pérez-Costas, E., Meléndez-Ferro, M., Pérez-García, C. G., Caruncho, H. J., and Rodicio, M. C. (2004). Reelin immunoreactivity in the adult sea lamprey brain. J. Chem. Neuroanat. 27:7-21.
Pérez-García, C. G., González-Delgado, F. J., Suárez-Solá, M. L., Castro-Fuentes, R., Martín-Trujillo, J. M., Ferres-Torres, R., and Meyer, G. (2001). Reelin-immunoreactive neurons in the adult vertebrate pallium. J. Chem. Neuroanat. 21:41-51.
Pérez-García, C. G., Tissir, F., Goffinet, A. M., and Meyer, G. (2004). Reelin receptors in develop-ing laminated brain structures of mouse and human. Eur. J. Neurosci. 20:2827-2832.
Persico, A. M., D’Agruma, L., Maiorano, N., Totaro, A., Militerni, R., Bravaccio, C., Wassink, T. H., Schneider, C., Melmed, R., Trillo, S., Montecchi, F., Palermo, M., Pascucci, T., Puglisi-Allegra, S., Reichelt, K. L., Conciatori, M., Marino, R., Quattrocchi, C. C., Baldi, A., Zelante, L., Gasparini, P., and Keller, F. (2001). Reelin gene alleles and haplotypes as a factor predisposing to autistic disorder. Mol. Psychiatry 6:150-159.
Pesold, C., Impagnatiello, F., Pisu, M. G., Uzunov, D. P., Costa, E., Guidotti, A., and Caruncho, H. J. (1998). Reelin is preferentially expressed in neurons synthesizing gamma-aminobutyric acid in cortex and hippocampus of adult rats. Proc. Natl. Acad. Sci. USA 95:3221-3226.
Pesold, C., Liu, W. S., Guidotti, A., Costa, E., and Caruncho, H. J. (1999). Cortical bitufted, horizontal, and Martinotti cells preferentially express and secrete reelin into perineuronal nets, nonsynaptically modulating gene expression. Proc. Natl. Acad. Sci. USA 96:3217-3222.
Pollard, K. S., Salama, S. R., Lambert, N., Lambot, M. A., Coppens, S., Pedersen, J. S., Katzman, S., King, B., Onodera, C., Siepel, A., Kern, A. D., Dehay, C., Igel, H., Ares, M., Jr., Vanderhaeghen, P., and Haussler, D. (2006). An RNA gene expressed during cortical development evolved rapidly in humans. Nature 443:167-172.
Pozniak, C. D., Radinovic, S., Yang, A., McKeon, F., Kaplan, D. R., and Miller, F. D. (2000). An anti-apoptotic role for the p53 family member, p73, during developmental neuron death. Science 289:304-306.
Qiu, S., and Weeber, E. J. (2007). Reelin signaling facilitates maturation of CA1 glutamatergic synapses. J. Neurophysiol. 97:2312-2321.
Ramos-Moreno, T., Galazo, M. J., Porrero, C., Martinez-Cerdeno, V., and Clasca, F. (2006). Extracellular matrix molecules and synaptic plasticity: immunomapping of intracellular and secreted reelin in the adult rat brain. Eur. J. Neurosci. 23:401-422.
Rice, D. S., and Curran, T. (2001). Role of the reelin signaling pathway in central nervous system development. Annu. Rev. Neurosci. 24:1005-1039.
Rice, D. S., Sheldon, M., D’Arcangelo, G., Nakajima, K., Goldowitz, D., and Curran, T. (1998). Disabled-1 acts downstream of reelin in a signaling pathway that controls laminar organization in the mammalian brain. Development 125:3719-3729.
Rice, D. S., Nusinowitz, S., Azimi, A. M., Martinez, A., Soriano, E., and Curran, T. (2001). The reelin pathway modulates the structure and function of retinal synaptic circuitry. Neuron 31:929-941.
Roberts, R. C., Xu, L., Roche, J. K., and Kirkpatrick, B. (2005). Ultrastructural localization of reelin in the cortex in post-mortem human brain. J. Comp. Neurol. 482:294-308.
Rodriguez, M. A., Pesold, C., Liu, W. S., Kriho, V., Guidotti, A., Pappas, G. D., and Costa, E. (2000). Colocalization of integrin receptors and reelin in dendritic spine postsynaptic densities of adult nonhuman primate cortex. Proc. Natl. Acad. Sci. USA 97:3550-3555.
Rodríguez, M. A., Caruncho, H. J., Costa, E., Pesold, C., Liu, W. S., and Guidotti, A. (2002). In Patas monkey, glutamic acid decarboxylase-67 and reelin mRNA coexpression varies in a manner dependent on layers and cortical areas. J. Comp. Neurol. 451:279-288.
Royaux, I., Lambert de Rouvroit, C., D’Arcangelo, G., Demirov, D., and Goffinet, A. M. (1997). Genomic organization of the mouse reelin gene. Genomics 46:240-250.
Saez-Valero, J., Costell, M., Sjogren, M., Andreasen, N., Blennow, K., and Luque, J. M. (2003). Altered levels of cerebrospinal fluid reelin in frontotemporal dementia and Alzheimer’s dis-ease. J. Neurosci. Res. 72:132-136.
Schiffmann, S. N., Bernier, B., and Goffinet, A. M. (1997). Reelin mRNA expression during mouse brain development. Eur. J. Neurosci. 9:1055-1071.
Steward, O., and Scoville, S. A. (1976). Cells of origin of entorhinal cortical afferents to the hip-pocampus and fascia dentata of the rat. J. Comp. Neurol. 169:347-370.
Tissir, F., and Goffinet, A. M. (2003). Reelin in brain development. Nature Rev. Neurosci. 4:496-505.
Tissir, F., Lambert de Rouvroit, C., and Goffinet, A. M. (2002). The role of reelin in the develop-ment and evolution of the cerebral cortex. Braz. J. Med. Biol. Res. 35:1473-1484.
Tissir, F., Lambert de Rouvroit, C., Sire, J. Y., Meyer, G., and Goffinet, A. M. (2003). Reelin expression during embryonic brain development in Crocodylus niloticus. J. Comp. Neurol. 457:250-262.
Trommsdorff, M., Gotthardt, M., Hiesberger, T., Shelton, J., Stockinger, W., Nimpf, J., Hammer, R. E., Richardson, J. A., and Herz, J. (1999). Reeler/disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2. Cell 97:689-701.
Ulinski, P. S. (1990). The cerebral cortex of reptiles. In: Jones, E. G., and Peters, A. (Eds.), Cerebral Cortex, Vol. 8A. Plenum Press, New York, pp. 139-215.
van Groen, T., Miettinen, P., and Kadish, I. (2003). The entorhinal cortex of the mouse: organiza-tion of the projection to the hippocampal formation. Hippocampus 13:133-149.
Van Hoesen, G. W., and Hyman, B. T. (1990). Hippocampal formation: anatomy and the patterns of pathology in Alzheimer’s disease. Prog. Brain Res. 83:445-457.
Weeber, E. J., Beffert, U., Jones, C., Christian, J. M., Forster, E., Sweatt, J. D., and Herz, J. (2002). Reelin and ApoE receptors cooperate to enhance hippocampal synaptic plasticity and learning. J. Biol. Chem. 277:39944-39952.
Willnow, T. E., Nykjaer, A., and Herz, J. (1999). Lipoprotein receptors: new roles for ancient pro-teins. Nature Cell Biol. 1:157-162.
Witter, M. P., and Groenewegen, H. J. (1984). Laminar origin and septotemporal distribution of entorhinal and perirhinal projections to the hippocampus in the cat. J. Comp. Neurol. 224:371-385.
Yang, A., Walker, N., Bronson, R., Kaghad, M., Oosterwegel, M., Bonnin, J., Vagner, C., Bonnet, H., Dikkes, P., Sharpe, A., McKeon, F., and Caput, D. (2000). p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours. Nature 404: 99-103.
Yoshida, M., Assimacopoulos, S., Jones, K. R., and Grove, E. A. (2006). Massive loss of Cajal-Retzius cells does not disrupt neocortical layer order. Development 133:537-545.
Zhao, S., Chai, X., Forster, E., and Frotscher, M. (2004). Reelin is a positional signal for the lamination of dentate granule cells. Development 131:5117-5125.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2008 Springer
About this chapter
Cite this chapter
Meyer, G. (2008). Comparative Anatomy and Evolutionary Roles of Reelin. In: Fatemi, S.H. (eds) Reelin Glycoprotein. Springer, New York, NY. https://doi.org/10.1007/978-0-387-76761-1_6
Download citation
DOI: https://doi.org/10.1007/978-0-387-76761-1_6
Publisher Name: Springer, New York, NY
Print ISBN: 978-0-387-76760-4
Online ISBN: 978-0-387-76761-1
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)