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Reelin Glycoprotein pp 227–235Cite as

Reelin and Thyroid Hormone

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Thyroid hormone [3,5,3′-triiodothyronine (T3) and thyroxine (T4)] is essential for proper brain development. In humans, the lack of adequate T3 levels during the perinatal period leads to cretinism, a syndrome associated with mental retardation and neurological deficits, such as ataxia, spasticity, and deafness (for review, see Legrand, 1984; Dussault and Ruel, 1987; Braverman and Utiger, 2000; Bernal, 2005a). These alterations are due to misregulation of the gene expression controlled by T3 through its interaction with nuclear receptors, which act as ligand-modulated transcription factors (Muñoz and Bernal, 1997; Forrest and Vennström, 2000; Yen et al., 2006).

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Authors and Affiliations

  1. Cellular Regeneration Laboratory, Centra de Investigatión Principe Felipe (CIPF), Avenida Autopista del Saler 16-3, Valencia, 46013, Spain

    Manuel Álvarez-Dolado

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  1. Manuel Álvarez-Dolado
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Editors and Affiliations

  1. Medical School, University of Minnesota, Minneapolis, MN, USA

    S. Hossein Fatemi M.D., Ph.D. (Professor of Psychiatry, Adjunct Professor of Pharmacology and Neuroscience) (Professor of Psychiatry, Adjunct Professor of Pharmacology and Neuroscience)

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Álvarez-Dolado, M. (2008). Reelin and Thyroid Hormone. In: Fatemi, S.H. (eds) Reelin Glycoprotein. Springer, New York, NY. https://doi.org/10.1007/978-0-387-76761-1_15

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