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Genetic Risks in Schizophrenia: Cross-National Prospective Longitudinal High-Risk Studies

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Handbook of Behavior Genetics

Prospective longitudinal studies are a powerful means to identify the causal chains of biological and environmental factors that underlie the development of serious mental disorders. Schizophrenia is one of these disorders. Schizophrenia is a multifactorial neurodevelopmental disorder whose specific molecular genetic, epigenetic, stochastic, and environmental bases remain elusive. The chronic debilitating nature of the disorder places a heavy emotional and financial burden on the individual, family, and society. Although the lifetime prevalence of schizophrenia is 1% in the general population that has passed through the risk period, it accounts for up to 3% of total national health-care expenditures in Western countries (). The hypothetical ability to intervene in the developmental progression of the disorder at a point before breakdown is contingent upon the elucidation of early behavioral and other markers of genetic liability to the disorder and their triggers. In this chapter, we focus on research aimed at early detection of markers that may predict to the later onset of schizophrenia. Once these markers are identified, intervention can, at least in principle, be targeted to those individuals most at risk for the disorder.

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Authors and Affiliations

  1. Department of Psychology, Ben-Gurion University, Beer-Sheva, Israel

    Judith G. Auerbach

  2. Center for Advanced Studies, Norwegian Academy of Science and Letters, Oslo, Norway

    Judith G. Auerbach

  3. Departments of Medical Genetics, New York State Psychiatric Institute, New York, NY 10032, USA

    L. Erlenmeyer-Kimling

  4. Departments of Psychiatry and of Genetics and Development, Columbia University, New York, NY, USA

    L. Erlenmeyer-Kimling

  5. Department of Psychiatry and Behavioral Sciences, University of California, Los Angeles, CA 90095, USA

    Barbara Fish

  6. School of Social Service Administration, University of Chicago, Chicago, IL 60637, USA

    Sydney L. Hans

  7. Department of Psychology, The George Washington University, Washington, DC 20037, USA

    Loring J. Ingraham

  8. Department of Psychiatry, University of Chicago, Chicago, IL 60637, USA

    Joseph Marcus

  9. Department of Psychiatric Epidemiology, University Hospital, Lund University, Israel

    Thomas F. McNeil & Erland Schubert

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  1. Judith G. Auerbach
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  2. L. Erlenmeyer-Kimling
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  3. Barbara Fish
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  4. Sydney L. Hans
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  5. Loring J. Ingraham
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  6. Joseph Marcus
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  7. Thomas F. McNeil
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  8. Erland Schubert
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Corresponding author

Correspondence to Judith G. Auerbach .

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Editors and Affiliations

  1. University of Georgia, Athens, GA, USA

    Yong-Kyu Kim Ph.D

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Auerbach, J.G. et al. (2009). Genetic Risks in Schizophrenia: Cross-National Prospective Longitudinal High-Risk Studies. In: Kim, YK. (eds) Handbook of Behavior Genetics. Springer, New York, NY. https://doi.org/10.1007/978-0-387-76727-7_32

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