Exfoliation Syndrome and Glaucoma

  • Anastasios G. P. Konstas
  • Gábor Holló
  • Robert Ritch


Exfoliative glaucoma (XFG) is the most common type of secondary open-angle glaucoma.1 Its worldwide prevalence makes it critical for ophthalmologists to be familiar with the full clinical spectrum of the disease.1–3 Exfoliation syndrome (XFS) and XFG were initially described in 1917 by the Finnish ophthalmologist John Lindberg. In 1924, it was determined that XFG develops from XFS. Both conditions currently affect 60-70 million people worldwide. Of these, 15-17 million people have increased intraocular pressure (IOP) and 5-6 million are estimated to suffer from XFG.3 Both XFS and XFG are characterized by the systemic synthesis and accumulation of an abnormal fibrillar material, called exfoliation material. Originally it was believed that the sole source of this abnormal material is the lens. The terms exfoliation material, XFS, XFG, and capsular glaucoma were introduced based on this early theory. True exfoliation of the lens capsule is a different and an exceedingly rare entity, which occurs as a consequence of thermal damage of the lens.


Trabecular Meshwork Pigment Granule Selective Laser Trabeculoplasty POAG Patient Deep Sclerectomy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Supported in part by a Pythagoras grant (Dr. Konstas); a Hungarian National Health Grant (ETT 001/2009), (Dr. Holló); and a Horizon Award, Allergan, Inc., and Edith C. Blum Foundation, New York, NY (Dr. Ritch).


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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Anastasios G. P. Konstas
    • 1
  • Gábor Holló
    • 2
  • Robert Ritch
    • 3
    • 4
  1. 1.Head Glaucoma Unit, 1st University Department of Ophthalmology, Ahepa HospitalThessalonikiGreece
  2. 2.1st Department of OphthalmologySemmelweis University School of MedicineBudapestHungary
  3. 3.Department of OphthalmologyThe New York Eye and Ear InfirmaryNew YorkUSA
  4. 4.Department of OphthalmologyThe New York Medical CollegeValhallaUSA

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