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Drug Addiction pp 327–339Cite as

Receptors of Mammalian Trace Amines

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Abstract

The discovery of a family of G-protein coupled receptors, some of which bind and are activated by biogenic trace amines, has prompted speculation as to the physiological role of these receptors. Observations associated with the distribution of these trace amine associated receptors (TAARs) suggest that they may be involved in depression, attention-deficit hyperactivity disorder, eating disorders, migraine headaches, and Parkinson’s disease. Preliminary in vitro data, obtained using cloned receptors, also suggest a role for TAARs in the function of hallucinogens.

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Author information

Authors and Affiliations

  1. Chemistry and Life Sciences, Research Triangle Institute, Research Triangle Park, NC

    Anita H. Lewin

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  1. Anita H. Lewin
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Correspondence to Anita H. Lewin .

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Editors and Affiliations

  1. National Institute on Drug Abuse, Bethesda, MD, USA

    Rao S. Rapaka

  2. College of Medicine and Public Health, Ohio State University, Columbus, OH, USA

    Wolfgang Sadée

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© 2008 American Association of Pharmaceutical Scientists

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Lewin, A.H. (2008). Receptors of Mammalian Trace Amines. In: Rapaka, R.S., Sadée, W. (eds) Drug Addiction. Springer, New York, NY. https://doi.org/10.1007/978-0-387-76678-2_20

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