Functional Implication of Taurine in Aging
Age-related impairment of central functions is though to result from alterations of neurochemical indices of synaptic function. These neurochemical modifications involve structural proteins, neurotransmitters, neuropeptides and related receptors. Several studies demonstrated that GABA receptors, glutamic acid decarboxylase (GAD65&67), and different subpopulations of GABAergic neurons are markedly decreased in experimental animal brains during aging. Thus, the age-related decline in cognitive functions could be attributable, at least in part, to decrements in the function of the GABAergic inhibitory neurotransmitter system. In this study we show that chronic supplementation of taurine to aged mice significantly ameliorated the age-dependent decline in memory acquisition and retention, and caused alterations in the GABAergic system. These changes include increased levels of the neurotransmitters GABA and glutamate, increased expression of glutamic acid decarboxylase and the neuropeptide somatostatin and increased in the number of somatostatin-positive neurons. These specific alterations of the inhibitory system caused by taurine treatment oppose those naturally-occurring during aging, and suggest a protective role of taurine in this process.
Increased understanding of age-related neurochemical changes in the GABAergic system will be important in elucidating the underpinnings of the functional changes of aging. Taurine might help forestall the age-related decline in cognitive functions through interaction with the GABAergic system.
KeywordsAged Mouse Inferior Colliculus GABAergic Neuron Glutamic Acid Decarboxylase Dark Compartment
Unable to display preview. Download preview PDF.
- Caspary DM, Raza A, Lawhorn Armour BA, Pippin J, Arnerić SP (1990) Immunocytochemical and neurochemical evidence for age-related loss of GABA in the inferior colliculus: implications for neural presbycusis. J Neurosci 10(7):2363-72.Google Scholar
- Davies P, Katzman R, Terry RD (1980) Reduced somatostatin-like immunoreactivity in cerebral cortex from cases of Alzheimer’s disease and Alzheimer senile dementia Nature 288:279–280Google Scholar
- Dournaud P, Jazat-Poindessous F, Slama A, Lamour Y, Epelbaum J (1996) Correlations between water maze performance and cortical somatostatin mRNA and high-affinity binding sites during ageing in rats Eur J Neurosci 8:476–485Google Scholar
- El Idrissi A, Messing J, Scalia J, Trenkner E (2003) Prevention of Epileptic Seizures through taurine. In: Lombardini JB, Schaffer SW, Azuma J (eds) Taurine 5 Beginning the 21st Century, Adv Exp Med Biol, Vol 526, Kluwer Press, NewYork, pp 515–525Google Scholar
- Kuriyama K, and Hashimoto T (1998) Interrelationship between taurine and GABA. Adv Exp Med Biol 442:329–337Google Scholar