Breast cancer is a significant public health problem in virtually all industrialized societies. In many developed countries it is the most common life-threatening malignancy and the second most frequent cause of cancer-related mortality. After peaking in the 1990s, and despite a gradual increase in incidence [1], the overall mortality for breast cancer has been declining in the United States and in some European countries [1, 2].
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Valagussa, P. (2009). History of Adjuvant Therapy. In: Castiglione, M., Piccart, M. (eds) Adjuvant Therapy for Breast Cancer. Cancer Treatment and Research, vol 151. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-75115-3_1
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