Microfluidics-Based Lysis of Bacteria and Spores for Detection and Analysis

  • Ning Bao
  • Chang Lu


The disruption of the membrane/coat, or lysis, of bacteria and spores is often a critical step for analyzing the intracellular molecules such as proteins and nucleic acids. In this chapter, we review recent advances in the application of microfluidic devices for lysis of bacteria and spores. We divide existent devices and methods into five categories: mechanical, chemical, thermal, laser, and electrical. We also point out future directions in this field.


Pulse Electric Field Microfluidic Chip Apple Juice Microfluidic System Bacterial Spore 
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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Ning Bao
    • 1
  • Chang Lu
    • 1
  1. 1.Department of Agricultural and Biological Engineering School of Chemical Engineering Birck Nanotechnology Center Bindley Bioscience CenterPurdue UniversityWest Lafayette

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