Abstract
Oxy- (HbO2) and deoxy- (HHb) haemoglobin signalsmeasured by near infrared (NIR) spectroscopy over the human frontal lobes frequently contain respiratory and low frequency oscillations (LFOs). It has been suggested previously that venous oxygen saturation (SvO2) can be calculated from these respiratory oscillations. In this paper, we investigated the use of a Fourier transform based algorithm to calculate an oxygen saturation measure known as SoscO2 which may be a close estimate of the underlying SvO2. SoscO2 was calculated using three different frequency ranges, (1) respiratory oscillations only, (2) LFOs only, and (3) both respiratory oscillations and LFOs. At each frequency range SoscO2 was calculated using either (1) the modified Beer-Lambert law (MBL) or (2) spatially resolved spectroscopy (SRS). In total six different measurements of SoscO2 were investigated here. Experiments were performed in six adult ventilated patients with traumatic brain injury. The patients’ inspired oxygen fraction (FiO2) was raised in two hyperoxic phases. The calculated SoscO2 values were compared with other cerebral oxygenation measures including an intraparenchymal catheter based brain tissue oxygen tension (PbrO2) and the NIR based tissue oxygenation index (TOI). It was found that the SoscO2 calculated using the combined respiratory and LFO frequency range and the SRS method resulted in the highest detection rates of hyperoxic changes.This measure of SoscO2 may provide a viable, continuous, non invasive, bedside measure of cerebral venous oxygen saturation.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
L. Skov, O. Pryds, G. Greisen, H. Lou, Estimation of cerebral venous saturation in newborn infants by near infrared spectroscopy, Pediatr Res 33(1), 52–55 (1993).
C. W. Yoxall, A. M. Weindling, The measurement of peripheral venous oxyhemoglobin saturation in newborn infants by near infrared spectroscopy with venous occlusion, Pediatr Res 39, 1103–1106 (1996).
C. E. Elwell, S. J. Matcher, L. Tyszczuk, J. H. Meek, D. T. Delpy, Measurement of cerebral venous saturation in adults using near infrared spectroscopy, Adv Exp Med Biol 411, 453–460 (1997).
C. E. Elwell, H. Owen-Reece, J. S. Wyatt, M. Cope, E. O. R. Reynolds, D. T. Delpy, Influence of respiration and changes in expiratory pressure on cerebral hemoglobin concentration measured by near-infrared spectroscopy, J Cereb Blood Flow Metab 16(2), 353–357 (1996).
M. Wolf, G. Duc, M. Keel, P. Niederer, K. von Siebenthal, H-U. Bucher, Continuous noninvasive measurement of cerebral arterial and venous oxygen saturation at the bedside in mechanically ventilated neonates, Crit Care Med 25(9), 1579–1582 (1997).
M. A. Franceschini, D. A. Boas, A. Zourabian, S. G. Diamond, S. Nadgir, D. W. Lin, J. B. Moore, S. Fantini, Near-infrared spiroximetry: noninvasive measurements of venous saturation in piglets and human subjects, J Appl Phyiol 92, 372–384 (2002).
L. Nilsson, A. Johansson, S. Kalman, Macrocirculation is not the sole determinant of respiratory induced variations in the reflection mode photoplethysmographic signal, Physiol Meas 24, 925–937 (2003).
R. M. Berne, M. N. Levy, Cardiovascular Physiology (7th ed.), St. Louis, MO: Mosby Year Book (1997).
C. E. Elwell, R. Springett, E. Hillman, D. T. Delpy, Oscillations in cerebral haemodynamics – implications for functional activation studies, Adv Exp Med Bio 471, 57–65 (1999).
H. Obrig, M. Neufang, R. Wenzel, M. Kohl, J. Steinbrink, K. Einhaupl, A. Villringer, Spontaneous low frequency oscillations of cerebral hemodynamics and metabolism in human adults, Neuroimage 12, 623–639 (2000).
I. Tachtsidis, C. E. Elwell, T. S. Leung, C. W. Lee, M. Smith, D. T. Delpy, Investigation of cerebral haemodynamics by near infrared spectroscopy in young healthy volunteers reveals posture dependent spontaneous oscillations, Physiol Meas 25(2), 437–445 (2004).
T. Katura, N. Tanaka, A. Obata, H. Sato, A. Maki, Quantitative evaluation of interrelations between spontaneous low-frequency oscillations in cerebral hemodynamics and systemic cardiovascular dynamics, Neuroimage, 31, 1592–1600 (2006).
A. C. Guyton, J. E. Hall, The textbook of medical physiology, 10th ed. W.B.Sunders Company, Philadelphia (2000).
K. Siebenthal, J. Beran, M. Wolf, M. Keel, V. Dietz, S. Kundu, H. U. Bucher, Cyclical fluctuations in blood pressure, heart rate and cerebral blood volume in preterm infants, Brain Dev 21(8), 529–534 (1999).
H. Nilsson, C. Aalkjaer, Vasomotion: mechanisms and physiological importance, Mol Interv 3(2), 79–89 (2003).
J. Nortje, A. K. Gupta, The role of tissue oxygen monitoring in patients with acute brain injury,Brit J Anaesthesia 97(1), 95–106 (2006).
S. Suzuki, S. Takasaki, T. Ozaki, Y. Kobayashi, A Tissue Oxygenation Monitor using NIR Spatially Resolved Spectroscopy, Proc SPIE 3597 582–592 (1999).
P. G. Al-Rawi, P. Smielewski, P. J. Kirkpatrick, Evaluation of a near-infrared spectrometer (NIRO 300) for the detection of intracranial oxygenation changes in the adult head. Stroke 32(11), 2492–2500 (2001).
H. M. Watzman, C. D. Kurth, L. M. Montenegro, J. Rome, J. M. Steven, S. C. Nicolson, Arterial and venous contributions to near-infrared cerebral oximetry, Anesthesiology 93, 947–953 (2000).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2008 Springer Science+Business Media, LLC
About this paper
Cite this paper
Leung, T.S., Tisdall, M.M., Tachtsidis, I., Smith, M., Delpy, D.T., Elwell, C.E. (2008). Cerebral Tissue Oxygen Saturation Calculated Using Low Frequency Haemoglobin Oscillations Measured by Near Infrared Spectroscopy in Adult Ventilated Patients. In: Kang, K.A., Harrison, D.K., Bruley, D.F. (eds) Oxygen Transport to Tissue XXIX. Advances In Experimental Medicine And Biology, vol 614. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-74911-2_27
Download citation
DOI: https://doi.org/10.1007/978-0-387-74911-2_27
Publisher Name: Springer, Boston, MA
Print ISBN: 978-0-387-74910-5
Online ISBN: 978-0-387-74911-2
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)