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Relative Antigenicity of Allograft Components and Differential Rejection

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Transplantation of Composite Tissue Allografts

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A composite tissue comprises tissues derived from all three germ layers: ectoderm, mesoderm, and endoderm. Following transplantation, each component induces an immune response, which differs in character and intensity.

Skin has been shown to be the most antigenic tissue and is the first tissue to be rejected in animal models and human transplants. The heightened antigenicity of skin has been attributed to Langerhans' dendritic cells and skin-specific antigens. Muscle, bone, cartilage, and nerve predictably induce a relatively lower immune response in that order. However, rejection of even one component of a composite tissue renders the entire allograft vulnerable to dysfunction.

The knowledge of relative antigenicity can lead to the development of strategies intended to decrease the antigenicity of a specific component. In addition, a better understanding of this relative antigenicity of allograft components enables the concept of tailored immunosuppression targeting only specific cellular and humoral components of rejection. This would limit the amount of immunosuppression used and the consequent related complications of opportunistic infections and malignancies.

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Authors and Affiliations

  1. Division of Plastic Surgery, Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania

    Jignesh Unadkat (Research Fellow) & Justin M. Sacks (Research Fellow)

  2. Division of Plastic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania

    Stefan Schneeberger (Research Assistant Professor of Surgery)

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  1. Jignesh Unadkat
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  2. Justin M. Sacks
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  3. Stefan Schneeberger
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  4. W. P. Andrew Lee
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Editors and Affiliations

  1. Division of Surgical Research UMDNJ-Robert Wood Johnson Medicine Medical School, Cooper University Hospital, Camden, New Jersey

    Charles W. Hewitt (Professor of Surgery Head) (Professor of Surgery Head)

  2. Division of Plastic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania

    W. P. Andrew Lee (Professor of Surgery and Orthopedic Surgery Chief) (Professor of Surgery and Orthopedic Surgery Chief)

  3. Department of Surgery UMDNJ-Robert Wood Johnson Medical School, Cooper University Hospital, Camden, New Jersey

    Chad R. Gordon (Chief Resident) (Chief Resident)

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Unadkat, J., Sacks, J.M., Schneeberger, S., Lee, W.P.A. (2008). Relative Antigenicity of Allograft Components and Differential Rejection. In: Hewitt, C.W., Lee, W.P.A., Gordon, C.R. (eds) Transplantation of Composite Tissue Allografts. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-74682-1_6

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