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Bioactive Components of Milk pp 241–250Cite as

A Proline-Rich Polypeptide from Ovine Colostrum: Colostrinin with Immunomodulatory Activity

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Part of the Advances in Experimental Medicine and Biology book series (AEMB,volume 606)

Abstract

A proline-rich polypeptide (PRP), later called colostrinin (CLN), was originally found as a fraction accompanying sheep colostral immunoglobulins. Extensive in vitro and in vivo studies in mice revealed its interesting T cell-tropic activities. The polypeptide promoted T cell maturation from early thymic precursors that acquired the phenotype and function of mature, helper cells; on the other hand, it also affected the phenotype and function of mature T cells. In particular, PRP was shown to recruit suppressor T cells in a model of T cell-independent humoral immune response and suppressed autoimmune hemolytic anemia in New Zealand Black mice. Subsequent in vitro studies in the human model revealed that CLN regulated mitogen-induced cytokine production in whole blood cultures. A discovery that CLN promoted procognitive functions in experimental animal models, supported by other laboratory findings, indicating prevention of pathological processes in the central nervous system, led to application of CLN in multicenter clinical trials. The trials demonstrated the therapeutic benefit of CLN in Alzheimer’s disease (AD) patients by delaying progress of the disease.

Keywords

  • Alzheimer Patient
  • Humoral Immune Response
  • Autoimmune Hemolytic Anemia
  • Guanidinium Chloride
  • Immunoregulatory Activity

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Authors and Affiliations

  1. The Institute of Immunology and Experimental Therapy, R. Weigla str. 12, 53-114 Wroclaw, Poland

    Michal Zimecki

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  1. Michal Zimecki
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Editors and Affiliations

  1. Agricultural Biotechnology Center, Gödöllo, Hungary

    Zsuzsanna Bösze

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Zimecki, M. (2008). A Proline-Rich Polypeptide from Ovine Colostrum: Colostrinin with Immunomodulatory Activity. In: Bösze, Z. (eds) Bioactive Components of Milk. Advances in Experimental Medicine and Biology, vol 606. Springer, New York, NY. https://doi.org/10.1007/978-0-387-74087-4_9

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