Bioactive Components of Milk pp 357-395

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 606) | Cite as

Producing Recombinant Human Milk Proteins in the Milk of Livestock Species

  • Zsuzsanna Bösze
  • Mária Baranyi
  • C. Bruce
  • A. Whitelaw

Abstract

Recombinant human proteins produced by the mammary glands of genetically modified transgenic livestock mammals represent a special aspect of milk bioactive components. For therapeutic applications, the often complex posttranslational modifications of human proteins should be recapitulated in the recombinant products. Compared to alternative production methods, mammary gland production is a viable option, underlined by a number of transgenic livestock animal models producing abundant biologically active foreign proteins in their milk. Recombinant proteins isolated from milk have reached different phases of clinical trials, with the first marketing approval for human therapeutic applications from the EMEA achieved in 2006.

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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Zsuzsanna Bösze
    • 1
  • Mária Baranyi
  • C. Bruce
  • A. Whitelaw
  1. 1.Agricultural Biotechnology CenterHungary

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