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EGF Receptor in Breast Cancer Chemoresistance

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Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 608)

Abstract

Acquisition of resistance of breast cancer to chemotherapy is commonly associated with progression of the disease to increased metastatic spread. Although early studies on this problem examined the possible roles of chemotherapy drug metabolism and efflux by resistant breast cancer cells, more recent work has implicated aberrant growth factor receptor and signal transduction pathways in the process for such commonly used drugs as the anthracyclines. Cell mutability, DNA repair defects, and loss of DNA damage checkpoint controls certainly must play key roles in the ability of cancer cells to evolve such resistance mechanisms.1,2

Keywords

Breast Cancer Epidermal Growth Factor Receptor Clin Oncol Pleckstrin Homology Domain Mouse Mammary Epithelial Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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© Landes Bioscience and Springer Science+Business Media 2007

Authors and Affiliations

  1. 1.Georgetown University Medical CenterWashington, DCUSA

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