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Pathogenesis of Group A Streptococcal Infections and Their Sequelae

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Hot Topics in Infection and Immunity in Children IV

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 609))

Streptococcus pyogenesor group A streptococci are Gram positive extracellular bacterial pathogens which colonize the throat or skin and are responsible for a number of suppurative infections and non-suppurative sequelae (Cunningham 2000). As pathogens they evade host defense mechanisms and exhibit a group of virulence determinants. Group A streptococci are a common cause of bacterial pharyngitis, scarlet fever or impetigo. The concept of distinct throat and skin strains arose from decades of epidemiological studies, where it became evident that there were serotypes of group A streptococci with a strong tendency to cause throat infection, and similarly, there were other serotypes often associated with skin infections (Bisno 1995b). The group A streptococcus is most well recognized for streptococcal toxic shock syndrome and necrotizing fasciitis which involves destruction of the skin and soft tissues in severe cases (Stevens 2000).

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Cunningham, M.W. (2008). Pathogenesis of Group A Streptococcal Infections and Their Sequelae. In: Finn, A., Pollard, A.J. (eds) Hot Topics in Infection and Immunity in Children IV. Advances in Experimental Medicine and Biology, vol 609. Springer, New York, NY. https://doi.org/10.1007/978-0-387-73960-1_3

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