Abstract
The extracellular matrix (ECM) of vertebrates is an important biological mechanotransducer that prevents premature mechanical failure of tissues and stores and transmits energy created by muscular deformation. It also transfers large amounts of excess energy to muscles for dissipation as heat, and in some cases, the ECM itself dissipates energy locally. Beyond these functions, ECMs regulate their size and shape as a result of the changing external loads. Changes in tissue metabolism are transduced into increases or decreases in synthesis and catabolism of the components of ECMs. Viscoelasticity is an important feature of the mechanical behavior of ECMs. This parameter, however, complicates the understanding of ECM behavior since it contains both viscous and elastic contributions in most real-time measurements made on vertebrate tissues.
The purpose of this chapter is to examine how time-dependent (viscous) and timeindependent (elastic) mechanical behaviors of an ECMare related to the hierarchical structure of vertebrate tissues and the macromolecular components found in specific tissues. In most ECMs, energy storage is believed to involve elastic stretching of collagen triple helices found in the cross-linked collagen fibrils comprising vertebrate connective tissues, and energy dissipation is believed to involve sliding of such collagen fibrils by each other during tissue deformation. It may be concluded that viscoelasticity differs markedly among different ECMs and is related to ECM hierarchical structure at the molecular and supramolecular levels of any particular vertebrate tissue.
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References
Alexander R M (1983) Animal Mechanics (2nd ed.). Blackwell Scientific, Oxford, UK.
Alexander R M (1984) Elastic energy stores in running vertebrates. A. Zool. 24, 85–94.
Arnoczky S P (1992) Gross and vascular anatomy of the meniscus and its role in meniscal healing, regeneration, and remodeling. In: Mow V C, Arnoczky S P, and Jackson D W (Eds.), Knee Meniscus: Basic and Clinical Foundations, Raven Press, New York, pp. 1–14.
Birk D E, Zycband E I, Winkelmann D A, Trelstad R L (1989) Collagen fibrillogenesis in situ: Fibril segments are intermediates in matrix assembly. Proc. Natl. Acad. Sci. U S A 86:4549–4553.
Christiansen D L, Huang E K, Silver F H (2000) Assembly of type I collagen: Fusions of fibril subunits and the influence of fibril diameter on mechanical properties. Matrix Biol. 19:409–420.
Dunn M G, Silver F H (1983) Viscoelastic behavior of human connective tissue: Relative contribution of viscous and elastic components. Connect. Tissue Res. 12: 59–70.
Freeman J W, Silver, F H (2004a) Analysis of mineral deposition in turkey tendons and self-assembled collagen fibers using mechanical techniques. Connect. Tissue Res. 45: 131–141.
Freeman J W, Silver F H (2004b) Elastic energy storage in unimineralized and mineralized extracellular matrices (ECMs): A comparison between molecular modeling and experimental measurements. J. Theor. Biol. 229: 371–381.
Freeman J W, Silver F H (2005) The effects of prestrain on in vitro mineralization of self-assembled collagen fibers. Connect. Tissue Res. 46: 107–155.
Landis W J, Silver, F H (2002) The structure and function of normally mineralizing tendons. Comp. Biochem. Physiol. A, 133: 1135–1157.
Landis W J, Silver F H, Freeman J (2006) Collagen as a scaffold for biomimetic mineralization of vertebrate tissues. J. Mater. Chem. 16: 1495–1503.
McBride D J (1984) Hind Limb Extensor Tendon Development in the Chick: A Light and Transmission Electron Microscopic Study. M.S. Thesis in Physiology, Rutgers University, Piscataway, NJ.
McBride D J, Hahn R, Silver F H (1985) Morphological characterization of tendon development during chick embryogenesis: Measurement of birefringence retardation. Int. J. Biol. Macromol. 7: 71–76.
McBride D J, Trelstad R L, Silver, F H (1988) Structural and mechanical assessment of developing chick tendon. Int. J. Biol. Macromol. 10: 194–200.
Mosler E, Folkhard W, Knorzer E., Nemetschek-Gansler H, Nemetschek T H, Koch M H (1985) Stress-induced molecular arrangement in tendon collagen. J. Mol. Biol. 182: 589–596.
Paterlini M G, Nemethy G, Scheraga H A (1995) The energy of formation of internal loops in triple-helical collagen polypeptides. Biopolymers 35: 607–619.
Rigby B J (1964) Effect of cyclic extension on the physical properties of tendon collagen and its possible relation to biological aging of collagen. Nature 202: 1072–1074.
Schoenfeld A, Landis W J, Kay D. (2007) Meniscal tissue engineering. Am. J. Orthop. 36:614–620.
Seehra G P, Silver F H (2006) Viscoelastic properties of acid- and alkaline-treated human dermis: A correlation between total surface charge and elastic modulus. Skin Res. Technol. 12:190–198.
Silver, F H (2006) Mechanosensing and Mechanochemical Transduction in Extracellular Matrix: Biological, Chemical, Engineering and Physiological Aspects, Springer, New York.
Silver F H, Birk D E (1984) Molecular structure of collagen in solution: Comparison of types I, II, III, and V. Int. J. Biol. Macromol. 6: 125–132.
Silver F H, Bradica G (2002) Mechanobiology of cartilage: how do internal and external stresses affect mechanochemical transduction and elastic energy storage? Biomechanics & Modeling in Mechanobiology 1: 1–19.
Silver F H, Christiansen D L (1999) Biomaterials Science and Biocompatibility, Chapter 6, Springer, New York.
Silver F H, Siperko L M (2003) Mechanosensing and mechanochemical transduction. Crit. Rev. Biomed. Eng. 31: 255–331.
Silver F H, Christiansen D L, Snowhill P, Chen Y (2000) Role of storage on changes in the mechanical properties of tendon and self-assembled collagen fibers. Connect. Tissue Res. 41: 155–164.
Silver F H, Christiansen D L, Snowhill P B, Chen Y (2001a) Transition from viscous to elastic-based dependency of mechanical properties of self-assembled type I collagen fibers. J. Appl. Polym. Sci. 79: 134–142.
Silver F H, Freeman J W, Horvath I, Landis W J (2001b) Molecular basis for elastic energy storage in mineralized tendon. Biomacromolecules 2: 750–756.
Silver F H, Freeman J, DeVore D (2001c) Viscoelastic properties of human skin and processed dermis. Skin Res. Technol. 7: 18–25.
Silver F H, Horvath I, Foran D (2001d) Viscoelasticity of the vessel wall: Role of collagen and elastic fibers. Crit. Rev. Biomed. Eng. 29: 279–301.
Silver F H, Bradica G, Tria A (2001e) Relationship among biomechanical, biochemical and cellular changes associated with osteoarthritis. Crit. Rev. Biomed. Eng. 29: 373–391.
Silver F H, Bradica G, Tria A (2001f) Viscoelastic behavior of osteoarthritic cartilage. Connect. Tissue Res. 42: 223–233.
Silver F H, Seehra P, Freeman J W, DeVore D (2002a) Viscoelastic properties of young and old human dermis: Evidence that elastic energy storage occurs in the flexible regions of collagen and elastin. J. Appl. Polym. Sci. 86: 1978–1985.
Silver F H, Bradica G, Tria A (2002b) Elastic energy storage in human articular cartilage: Estimation of the elastic spring constant for type II collagen and changes associated with osteoarthritis. Matrix Biol. 21: 129–137.
Silver F H, Ebrahimi A, Snowhill P B (2002c) Viscoelastic properties of self-assembled type I collagen fibers: Molecular basis of elastic and viscous behaviors. Connect. Tissue Res. 43: 1–12.
Silver F H, Horvath I, Foran D J (2002d) Mechanical implications of the domain structure of fibril forming collagens: Comparison of the molecular and fibrillar flexibility of α -chains found in types I, II and III collagens. J. Theor. Biol. 216: 243–254.
Silver F H, Siperko L M, Seehra G P (2002e) Mechanobiology of force transduction in dermis. Skin Res. Technol. 8: 1–21.
Silver F H, DeVore D, Siperko L M (2003a) Invited Review: Role of mechanophysiology in aging of ECM: Effects of changes in mechanochemical transduction. J. Appl. Physiol. 95: 2134–2141.
Silver F H, Snowhill P B, Foran D (2003b) Mechanical behavior of vessel wall: A comparative study of aorta, vena cava, and carotid artery. Ann. Biomed. Eng. 31: 793–803.
Silver F H, Freeman J, Seehra G P (2003c) Collagen self-assembly and development of matrix mechanical properties. J. Biomech. 36: 1529–1553.
Silver F H, Bradica G., Tria A (2004) Do changes in mechanical properties of articular cartilage alter mechanochemical transduction and promote osteoarthritis? Matrix Biol. 23: 467–476.
Snowhill P B, Silver F H (2005) A mechanical model of porcine vascular tissues-Part II: Stress–strain and mechanical properties of juvenile porcine blood vessels. Cardiovasc. Eng. 5:157–169.
Snowhill P B, Foran D J, Silver F H (2004) A mechanical model of porcine vascular tissues-Part I. Determination of macromolecular component arrangement and volume fractions. Cardiovasc. Eng. 4: 281–294.
Wilson A M, McGuigan M P, Su A, van den Bogert A J (2001) Horses damp the spring in their step. Nature 414: 895–899.
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Silver, F., Landis, W. (2008). Viscoelasticity, Energy Storage and Transmission and Dissipation by Extracellular Matrices in Vertebrates. In: Fratzl, P. (eds) Collagen. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-73906-9_6
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DOI: https://doi.org/10.1007/978-0-387-73906-9_6
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