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Targeted Therapies in Cancer pp 100–111Cite as

Anticancer Cell Therapy with TRAIL-Armed CD34+ Progenitor Cells

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 610))

Dysregulated apoptosis plays a key role in the pathogenesis and progression of neoplastic disorders, allowing tumor cells to survive beyond their normal life-span, and to eventually acquire chemo-radioresistance (Laconi, Pani and Farber, 2000; Pommier, Sordet, Antony, Hayward and Kohn 2004). Thus, apoptotic pathways represent attractive therapeutic targets for restoring apoptosis sensitivity of malignant cells, or activating agonists of apoptosis. To modulate apoptotic genes and proteins, several strategies can be envisaged which target either the mitochondria-dependent or the death receptor-dependent pathways of apoptosis (Waxman and Schwartz 2003). Due to the ability of death receptor ligands to induce death in susceptible cell types, there has been considerable interest in the therapeutic potential of these cytokines as anticancer agents. Death receptor ligands of the tumor necrosis factor α (TNFα) superfamily are type II transmembrane proteins that signal to target cells upon cell-cell contact, or after protease-mediated release to the extracellular space (Ashkenazi 2002). Four members of this family—including Fas ligand (FasL), TNFα, TL1A, and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)—stand out because of their ability to induce cell death (Wiley, Schooley, Smolak, Din, Huang, Nicholl, Sutherland, Smith, Rauch and Smith 1995; Wajant 2003).

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Authors and Affiliations

  1. Department of Medical Oncology, University of Milano and Istituto Nazionale Tumori, Milano, Italy

    Carmelo Carlo-Stella, Cristiana Lavazza & Alessandro M. Gianni

  2. Department of Pathology, Istituto Nazionale Tumori, Milano, Italy

    Antonino Carbone

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  1. Carmelo Carlo-Stella
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  2. Cristiana Lavazza
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  1. Nerviano Medical Sciences, 10 Viale Pasteur, Nerviano (Milano), 20014, Italy

    Francesco Colotta

  2. Istituto Clinico Humanitas and Institute of Pathology, University of Milan, 56 Via Manzoni, Rozzano, Milano, 20089, Italy

    Alberto Mantovani

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Carlo-Stella, C., Lavazza, C., Carbone, A., Gianni, A.M. (2008). Anticancer Cell Therapy with TRAIL-Armed CD34+ Progenitor Cells. In: Colotta, F., Mantovani, A. (eds) Targeted Therapies in Cancer. Advances in Experimental Medicine and Biology, vol 610. Springer, New York, NY. https://doi.org/10.1007/978-0-387-73898-7_8

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