Signalling Pathways and Adhesion Molecules as Targets for Antiangiogenesis Therapy in Tumors

  • Gianfranco Bazzoni
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 610)

In the embryo, blood vessels derive from endothelial precursors in a process called vasculogenesis. These progenitors assemble into a primitive vascular plexus. Subsequently, in a process called angiogenesis, the primitive vascular plexus expands by means of vessel sprouting and organizes into a network of blood vessels. Finally, the developing vessels are reinforced by the association with pericytes and smooth muscle cells (Coultas, et al. 2005). In parallel, in a process called lymphangiogenesis, lymphatic endothelial cells, which derive from embryonic veins by sprouting, form primary lymph sacs and the primary lymphatic plexus (Alitalo and Carmeliet 2002).


Vascular Endothelial Growth Factor Adherens Junction Embryonic Lethality Vascular Development Lymphatic Endothelial Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer 2008

Authors and Affiliations

  • Gianfranco Bazzoni
    • 1
  1. 1.Department of Biochemistry and Molecular PharmacologyIstituto di Ricerche Farmacologiche Mario NegriMilanoItaly

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