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MRI-Guided FUS and its Clinical Applications

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Image-Guided Interventions

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Focused ultrasound offers a completely noninvasive means to deliver energy to targeted locations deep within the body. It is actively being investigated for thermal ablation to offer a noninvasive alternative to surgical resection, and for altering tissue or cell membrane properties as a means to enhance or enable the delivery of drugs at targeted locations. Although focused ultrasound technology has been investigated for more than 60 years, it has not found widespread use because of the difficulty of guiding and monitoring the procedure. One needs to accurately identify the target tissue, confirm that the focal point is correctly targeted before high energies are employed, ensure that sufficient energy is delivered safely to the entire target, and evaluate the outcome after the treatment. Combining focused ultrasound with MRI overcomes all of these problems through MRI’s abilities to create high quality anatomical images and to quantify temperature changes. This chapter provides an overview of the marriage of these two technologies. We describe the basics of focused ultrasound technology and MRI methods to guide thermal therapies. This chapter also describes how this technology is currently being used in the clinic, and overviews some new opportunities that are being developed, such as targeted drug delivery in the brain.

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Authors and Affiliations

  1. Brigham & Women's Hospital, Boston, MA, USA

    Ferenc Jolesz, Nathan McDannold, Greg Clement, Manabu Kinoshita, Fiona Fennessy & Clare Tempany

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  1. Ferenc Jolesz
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  2. Nathan McDannold
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  3. Greg Clement
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  4. Manabu Kinoshita
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  1. University of Western Ontario, 100 Perth Drive, N6A 5K8, London, ON, Canada

    Terry Peters

  2. Imaging Science and Information Systems (ISIS) Center, 2115 Wisconsin Ave, 20057, Washington, DC, USA

    Kevin Cleary

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Jolesz, F., McDannold, N., Clement, G., Kinoshita, M., Fennessy, F., Tempany, C. (2008). MRI-Guided FUS and its Clinical Applications. In: Peters, T., Cleary, K. (eds) Image-Guided Interventions. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-73858-1_10

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