High Throughput Production and Screening Strategies for Creating Advanced Biomaterials and Chemical Sensors

  • William G. Holthoff
  • Loraine T. Tan
  • Ellen L. Holthoff
  • Ellen M. Cardone
  • Frank V. BrightEmail author
Part of the Integrated Analytical Systems book series (ANASYS)


Development of new materials is needed for numerous applications in engineering, medical, and scientific arenas. In this chapter, we describe some of our research efforts that focus on developing strategies and tools for high throughput production and screening to create advanced biomaterials and chemical sensors. Using our developed tools, we are able to produce and screen a wide array of materials in a short period of time. In several current embodiments, the system can readily produce and fully screen 100–1,000 samples/day. Our developed automated systems can provide results with minimal user input, yet with better precision and accuracy in comparison to traditional manual methods.


Sensor Array Sensor Element Hybrid Class Quencher Molecule High Throughput Production 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



The work from our laboratories was generously supported by the National Science Foundation, the National Institute of Health, the Gerald A. Sterbutzel fund at UB, and the John R. Oishei Foundation.


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Copyright information

© Springer Science + Business Media, LLC 2009

Authors and Affiliations

  • William G. Holthoff
    • 1
  • Loraine T. Tan
    • 2
  • Ellen L. Holthoff
  • Ellen M. Cardone
    • 3
  • Frank V. Bright
    • 4
    Email author
  1. 1.Joint Expeditionary Forensics Program, Naval Surface Warfare Center DahlgrenAsymmetric Operations Technology Branch (Z11)DahlgrenUSA
  2. 2.Department of Chemistry, University at BuffaloThe State University of New YorkBuffaloUSA
  3. 3.Department of ChemistryThe State University of New YorkBuffaloUSA
  4. 4.Department of Chemistry, Natural Sciences Complex, University at BuffaloThe State University of New YorkBuffaloUSA

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