A Computer Model of Mammalian Central CO2 Chemoreception
We developed a single compartment model of a mammalian CO2 sensitive neuron and tested the hypothesis that pH-dependent inhibition of multiple potassium channels contributes to CO2 sensitivity. pH-dependent inhibition of potassium channels by either intracellular or extracellular pH was sufficient to alter neuronal activity, but changes in neither intracellular nor extracellular pH are required to elicit a neuronal response to hypercapnic stimulation.
KeywordsFiring Rate Potassium Channel Extracellular Acidification Hypercapnic Acidosis Task Channel
Unable to display preview. Download preview PDF.
- Nottingham, S., Leiter, J.C., Wages, P., Buhay, S. and Erlichman, J.S. (2001) Developmental changes in intracellular pH regulation in medullary neurons of the rat. Am. J. Physiol. 281, R1940–R1951.Google Scholar