Reactive oxygen species (ROS) likely play a role in the hypoxic ventilatory response. We determined whether hypoxic responses were influenced by alterations in cellular redox status induced by reductions in superoxide dismutase-1 (SOD-1) activity, a cytosolic anti-oxidant enzyme. Using whole-body, continuous-flow plethysmography, we compared ventilatory responses to moderate hypoxia (10% inspired O2) of Sod1 +/+, +/− and −/− postnatal day 4 (P4) littermates. Sod1 +/− neonates exhibited a consistently lower breathing frequency than their wild-type littermates, regardless of inspired O2 level. While SOD-1 deficiency had no effect on the magnitude of the ventilatory response during hypoxia, it did compromise stability of breathing in the post-hypoxic period. Our results suggest SOD-1 stimulates ventilation and helps stabilize breathing after a hypoxic perturbation.
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References
Bissonnette, J.M. and S.J. Knopp, S.J. (2001) Developmental changes in the hypoxic ventil-atory response in C57BL/6 mice. Respir. Physiol. 128(2), 179–186.
Brown, D.R. et al. (1993) Breathing periodicity in intact and carotid body-denervated ponies during normoxia and chronic hypoxia. J. Appl. Physiol. 74(3), 1073–1082.
Cummings, K.J., et al. (2004) Sudden neonatal death in PACAP-deficient mice is associated with reduced respiratory chemoresponse and susceptibility to apnoea. J. Physiol. 555(Pt. 1), 15–26.
Elchuri, S., et al. (2005) CuZnSOD deficiency leads to persistent and widespread oxidative damage and hepatocarcinogenesis later in life. Oncogene 24(3), 367–380.
He, L., et al. (2005) Effect of p47phox gene deletion on ROS production and oxygen sensing in mouse carotid body chemoreceptor cells. Am. J. Physiol. Lung Cell Mol. Physiol. 289(6), L916–L924.
Kemp, P.J. (2006) Detecting acute changes in oxygen: will the real sensor please stand up? Exp. Physiol. 91(5), 829–834.
Roy, A. et al. (2000) Mice lacking in gp91 phox subunit of NAD(P) H oxidase showed glomus cell [Ca2+]i and respiratory responses to hypoxia. Brain Res. 872 (1–2), 188–193.
Tankersley, C.G. et al. (1994) Differential control of ventilation among inbred strains of mice. Am. J. Physiol. 267(5 Pt. 2), R1371–R1377.
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Cummings, K.J., Kalf, D., Moore, S., Miller, B.J., Jirik, F.R., Wilson, R.J.A. (2008). Superoxide Dismutase-1 Influences the Timing and Post-hypoxic Stability of Neonatal Breathing. In: Poulin, M.J., Wilson, R.J.A. (eds) Integration in Respiratory Control. Advances in Experimental Medicine and Biology, vol 605. Springer, New York, NY. https://doi.org/10.1007/978-0-387-73693-8_23
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DOI: https://doi.org/10.1007/978-0-387-73693-8_23
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