Skip to main content
SpringerLink
Log in

Activity-Dependent Bigenomic Transcriptional Regulation of Cytochrome c Oxidase in Neurons

  • Chapter
Transcriptional Regulation by Neuronal Activity

Abstract

Cytochrome c oxidase, a sensitive indicator of neuronal metabolic capacity and activity, is one of only four proteins in mammalian cells that are bigenomically encoded. The mitochondrial and nuclear genomes have to coordinate to form a functional holoenzyme with 13 subunits. Nuclear respiratory factors 1 and 2 (NRF-1 and NRF-2) are viable candidates for such bigenomic coordination, most likely in association with coactivators, such as peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1α). These three factors are themselves regulated by neuronal activity.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Anderson, S., Bankier, A.T., Barrell, B.G., de Bruijn, M.H., Coulson, A.R., Drouin, J., Eperon, I.C., Nierlich, D.P., Roe, B.A., Sanger, F., Schreier, P.H., Smith, A.J., Staden, R. and Young, I.G. (1981) Sequence and organization of the human mitochondrial genome. Nature 290, 457–465.

    Article  PubMed  CAS  Google Scholar 

  • Andersson, U. and Scarpulla, R.C. (2001) PGC-1-related coactivator, a novel, serum-inducible coactivator of nuclear respiratory factor 1-dependent transcription in mammalian cells. Mol. Cell Biol. 21, 3738–3749.

    Article  PubMed  CAS  Google Scholar 

  • Arany, Z., Novikov, M., Chin, S., Ma, Y., Rosenzweig, A. and Speigelman, B.M. (2006) Transverse aortic constriction leads to accelerated heart failure in mice lacking PPAR-γ coactivator 1α . Proc. Natl. Acad. Sci. 103, 10086–10091.

    Google Scholar 

  • Baar, K., Wende, A.R., Jones, T.E., Marison, M., Nolte, L.A., Chen, M., Kelly, D.P. and Holloszy, J.O. (2002) Adaptations of skeletal muscle to exercise: rapid increase in the transcriptional coactivator PGC-1. Faseb. J. 16, 1879–1886.

    Article  PubMed  CAS  Google Scholar 

  • Bachman, N.J., Yang, T.L., Dasen, J.S., Ernst, R.E. and Lomax, M.I. (1996) Phylogenetic footprinting of the human cytochrome c oxidase subunit VB promoter. Arch. Biochem. Biophys. 333, 152–162.

    Article  PubMed  CAS  Google Scholar 

  • Basu, A., Park, K., Atchison, M.L., Carter, R.S. and Avadhani, N.G. (1993) Identification of a transcriptional initiator element in the cytochrome c oxidase subunit Vb promoter which binds to transcription factors NF-E1 (YY-1, delta) and Sp1. J. Biol. Chem. 268, 4188–4196.

    PubMed  CAS  Google Scholar 

  • Bengtsson, J., Gustafsson, T., Widegren, U., Jansson, E. and Sundberg, C. (2001) Mitochondrial transcription factor A and respiratory complex IV increase in response to exercise training in humans. Pflugers Arch. 443, 61–66.

    Article  PubMed  CAS  Google Scholar 

  • Carter, R.S. and Avadhani, N.G. (1994) Cooperative binding of GA-binding protein transcription factors to duplicated transcription initiation region repeats of the cytochrome c oxidase subunit IV gene. J. Biol. Chem. 269, 4381–4387.

    PubMed  CAS  Google Scholar 

  • Carter, R.S., Bhat, N.K., Basu, A.. and Avadhani, N.G. (1992) The basal promoter elements of murine cytochrome c oxidase subunit IV gene consist of tandemly duplicated ets motifs that bind to GABP-related transcription factors. J. Biol. Chem. 267, 23418–23426.

    PubMed  CAS  Google Scholar 

  • Chantrel-Groussard, K., Deply, L., Ratinaud, M.H. and Cogne, M. (2001) Characterization of the murine gene for subunit VIIaL of cytochrome c oxidase. C.R. Adem. Sci. III 324, 1117–1123.

    CAS  Google Scholar 

  • Chaudhuri, A., Matsubara, J.A. and Cynader, M.S. (1995) Neuronal activity in primate visual cortex assessed by immunostaining for the transcription factor Zif268. Vis. Neurosci. 12, 35–50.

    Article  PubMed  CAS  Google Scholar 

  • Clayton, D.A. (1991) Replication and transcription of vertebrate mitochondrial DNA. Annu. Rev. Cell Biol. 7, 409–435.

    Article  Google Scholar 

  • Clayton, D.A. (2000) Transcription and replication of mitochondrial DNA. Hum. Reprod. 15 Suppl. 2 11–17

    PubMed  Google Scholar 

  • Dairaghi, D.J., Shadel, G.S. and Clayton, D.A. (1995) Addition of a 29 residue carboxyl-terminal tail converts a simple HMG box-containing protein into a transcriptional activator. J. Mol. Biol. 249, 11–28.

    Article  PubMed  CAS  Google Scholar 

  • Ekstrand, M.I., Falkenberg, M., Rantanen, A., Park, C.B., Gaspari, M., Hultenby, K., Rustin, P., Gustafsson, C.M. and Larsson, N.G.. (2004) Mitochondrial transcription factor A regulates mtDNA copy number in mammals. Human Mol. Genetics 13, 935–944.

    Article  CAS  Google Scholar 

  • Evans, M.J. and Scarpulla, R.C. (1989) Interaction of nuclear factors with multiple sites in the somatic cytochrome c promoter. Characterization of upstream NRF-1, ATF, and intron Sp1 recognition sequences. J. Biol. Chem. 264, 14361–14368.

    PubMed  CAS  Google Scholar 

  • Evans, M.J. and Scarpulla, R.C. (1990) NRF-1: a trans-activator of nuclear-encoded respiratory genes in animal cells. Genes Dev. 4, 1023–1034

    Article  PubMed  CAS  Google Scholar 

  • Falkenberg, M., Gaspari, M., Rantanen, A., Trifunovic, A., Larsson, N.G.. and Gustafsson, C.M. (2002) Mitochondrial transcription factors B1 and B2 activate transcription of human mtDNA. Nat. Genet. 31, 289–294.

    Article  PubMed  CAS  Google Scholar 

  • Fisher, R.P. and Clayton, D.A. (1988) Purification and characterization of human mitochondrial transcription factor 1. Mol. Cell Biol. 8, 3496–3509.

    PubMed  CAS  Google Scholar 

  • Gleyzer, N., Vercauteren, K. and Scarpulla, R.C. (2005) Control of mitochondrial transcription specificity factors (TFB1M and TFB2M) by nuclear respiratory factors (NRF-1 and NRF-2) and PGC-1 family coactivators. Mol. Cell Biol. 25, 1354–1366.

    Article  PubMed  CAS  Google Scholar 

  • Gopalakrishnan, L. and Scarpulla, R.C. (1995) Structure, expression, and chromosomal assignment of the human gene encoding nuclear respiratory factor 1. J. Biol. Chem. 270, 18019–18025.

    Article  PubMed  CAS  Google Scholar 

  • Goto, M., Terada, S., Kato, M., Katoh, M., Yokozeki, T., Tabata, I. and Shimokawa, T. (2000) cDNA Cloning and mRNA analysis of PGC-1 in epitrochlearis muscle in swimming-exercised rats. Biochem. Biophys. Res. Commun. 274, 350–354.

    Article  PubMed  CAS  Google Scholar 

  • Gordon, J.W., Rungi, A.A., Inagaki, H. and Hood, D.A. (2001) Effects of contractile activity on mitochondrial transcription factor A expression in skeletal muscle. J. Appl. Physiol. 90, 389–396.

    Article  PubMed  CAS  Google Scholar 

  • Grossman, L.I., Lomax, M.I. (1997) Nuclear genes for cytochrome c oxidase. Biochim. Biophys. Acta 1352, 174–192.

    PubMed  CAS  Google Scholar 

  • Gugneja, S., Virbasius, C.M. and Scarpulla, R.C. (1996) Nuclear respiratory factors 1 and 2 utilize similar glutamine-containing clusters of hydrophobic residues to activate transcription. Mol. Cell Biol. 16, 5708–5716.

    PubMed  CAS  Google Scholar 

  • Guo, A.L., Nie, F. and Wong-Riley, M.T.T. (2000) Human brain nuclear respiratory factor (NRF) 2α cDNA: Isolation, subcloning, sequencing and in situ hybridization of transcripts in normal and visually deprived macaque visual system. J. Comp. Neurol. 417, 221–232.

    Article  PubMed  CAS  Google Scholar 

  • Hevner, R.F. and Wong-Riley, M.T.T. (1991) Neuronal expression of nuclear and mitochondrial genes for cytochrome oxidase (CO) subunits analyzed by in situ hybridization: comparison with CO activity and protein. J. Neurosci. 11, 1942–1958.

    PubMed  CAS  Google Scholar 

  • Hevner, R.F. and Wong-Riley, M.T.T. (1993) Mitochondrial and nuclear gene expression for cytochrome oxidase subunits are disproportionately regulated by functional activity in neurons. J. Neurosci. 13, 1805–1819.

    PubMed  CAS  Google Scholar 

  • Herdegen, T., Kovary, K., Buhl, A., Bravo, R., Zimmermann, M. and Gass, P. (1995) Basal expression of the inducible transcription factors c-Jun, Jun B, Jun D, c-Fos, Fos B, and Krox-24 in the adult rat brain. J. Comp. Neurol. 354, 39–56.

    Article  PubMed  CAS  Google Scholar 

  • Hoshinaga, H., Amuro, N., Goto, Y. and Okazaki, T. (1994) Molecular cloning and characterization of the rat cytochrome c oxidase subunit Vb gene. J. Biochem. (Tokyo) 115, 194–201.

    CAS  Google Scholar 

  • Huo, L. and Scarpulla, R.C. (1999) Multiple 5’-untranslated exons in the nuclear respiratory factor 1 gene span 47 kb and contribute to transcript heterogeneity and translational efficiency. Gene 233, 213–224.

    Article  PubMed  CAS  Google Scholar 

  • Huo, L., Scarpulla, R.C. (2001) Mitochondrial DNA instability and peri-implantation lethality associated with targeted disruption of nuclear respiratory factor 1 in mice. Mol. Cell Biol. 21, 644–654.

    Article  PubMed  CAS  Google Scholar 

  • Hüttemann, M., Muhlenbein, N., Schmidt, T.R., Grossman, L.I. and Kadenbach, B. (2000) Isolation and sequence of the human cytochrome c oxidase subunit VIIaL gene. Biochim. Biophys. Acta 1492, 252–258.

    PubMed  Google Scholar 

  • Inagaki, H., Kitano, S., Lin, K.H., Maeda, S. and Saito, T. (1998) Inhibition of mitochondrial gene expression by antisense RNA of mitochondrial transcription factor A (mtTFA). Biochem. Mol. Biol. Int. 45, 567–573.

    PubMed  CAS  Google Scholar 

  • Inagaki, H., Hayashi, T., Matsushima, Y., Lin, K.H., Maeda, S., Ichihara, S., Kitagawa, Y. and Saito, T. (2000) Isolation of rat mitochondrial transcription factor A (r-Tfam) cDNA. DNA Seq. 11, 131–135.

    PubMed  CAS  Google Scholar 

  • Irrcher, I., Adhihetty, P.J., Sheehan, T., Joseph, A.M. and Hood, D.A. (2003) PPARgamma coactivator-1alpha expression during thyroid hormone- and contractile activity-induced mitochondrial adaptations. Am. J. Physiol. Cell Physiol. 284, C1669–1677.

    PubMed  CAS  Google Scholar 

  • Kadenbach, B., Jarausch, J., Hartmann, R. and Merle, P. (1983) Separation of mammalian cytochrome c oxidase into 13 polypeptides by a sodium dodecyl sulfate-gel eletrophoretic procedure. Analyt. Biochem. 129, 517–521.

    Article  PubMed  CAS  Google Scholar 

  • Kadenbach, B., Hüttemann, M., Arnold, S., Lee, I. and Bender, E. (2000) Mitochondrial energy metabolism is regulated via nuclear-cpded subunits of cytochrome c oxidase. Free Rad. Biol. Med. 29, 211–221.

    Article  PubMed  CAS  Google Scholar 

  • Kelly, D.P. and Scarpulla, R.C. (2004) Transcriptional regulatory circuits controlling mitochondrial biogenesis and function. Genes Dev. 18, 357–368.

    Article  PubMed  CAS  Google Scholar 

  • Knutti, D. and Kralli, A. (2001) PGC-1, a versatile coactivator. Trends Endocrinol. Metab. 12, 360–365.

    Article  PubMed  CAS  Google Scholar 

  • LaMarco, K., Thompson, C.C., Byers, B.P., Walton, E.M. and McKnight, S.L. (1991) Identification of Ets- and Notch-related subunits in GA-binding protein. Science 253, 789–792.

    Google Scholar 

  • Larsson, N.G., Barsh, G.S. and Clayton, D.A. (1997) Structure and chromosomal localization of the mouse mitochondrial transcription factor A gene (Tfam). Mamm. Genome 8, 139–140.

    Article  PubMed  CAS  Google Scholar 

  • Larsson, N.G., Wang, J., Wilhelmsson, H., Oldfors, A., Rustin, P., Lewandoski, M., Barsh, G.S. and Clayton, D.A. (1998) Mitochondrial transcription factor A is necessary for mtDNA maintenance and embryogenesis in mice. Nat. Genet. 18, 231–236.

    Article  PubMed  CAS  Google Scholar 

  • Liang, H.L. and Wong-Riley, M.T.T. (2006) Activity-dependent regulation of nuclear respiratory factor-1, nuclear respiratory factor-2, and peroxisome proliferators-activated receptor gamma coactivator-1 in neurons. NeuroReport 17, 401–405.

    Article  PubMed  CAS  Google Scholar 

  • Liang, H.L., Ongwijitwat, S. and Wong-Riley, M.T.T. (2006) Bigenomic functional regulation of all 13 cytochrome c oxidase subunit transcripts in rat neurons in vitro and in vivo. Neurosci. 140, 177–190.

    Article  CAS  Google Scholar 

  • Lin, J., Wu, H., Tarr, P.T., Zhang, C.Y., Wu, Z., Boss, O., Michael, L.F., Puigserver, P., Isotani, E., Olson, E.N., Lowell, B.B., Bassel-Duby. R. and Spiegelman, B.M. (2002) Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres. Nature 418, 797–801.

    Article  PubMed  CAS  Google Scholar 

  • Lin, J., Wu, P.-H., Tarr, P.T., Lindenberg, K.S., St-Pierre, J., Zhang, C.Y., Mootha, V.K., Jäger, S., Vianna, C.R., Reznick, R.M., Cui, L., Manieri, M., Donovan, M.X., Wu, Z., Cooper, M.P., Fan, M.C., Rohas, L.M., Zavacki, A.M., Cinti, S., Shulman, G.I., Lowell, B.B., Krainc. D. and Spiegelman, B.M. (2004) Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1α null mice. Cell 119, 121–135.

    Article  PubMed  CAS  Google Scholar 

  • Liu, S. and Wong-Riley, M.T.T. (1994) Nuclear-encoded mitochondrial precursor protein: Intramitochondrial delivery to dendrites and axon terminals of neurons and regulation by neuronal activity. J. Neurosci. 14, 5338–5351.

    PubMed  CAS  Google Scholar 

  • Lowry, O.H. (1975) Energy metabolism in brain and its control. In: D.H. Ingvar and N.A. Lassen (Eds.), Brain Work. Alfred Benzon Symposium VIII. Academic Press, New York, pp. 377–388.

    Google Scholar 

  • McCulloch, V. and Shadel, G.S. (2003) Human mitochondrial transcription factor B1 interacts with the C-terminal activation region of h-mtTFA and stimulates transcription independent of its RNA methyltransferase activity. Mol. Cell. Biol. 23, 5816–5824.

    Article  PubMed  CAS  Google Scholar 

  • Mell, O.C., Seibel, P. and Kadenbach, B. (1994) Structural organization of the rat genes encoding liver- and heart-type of cytochrome c oxidase subunit VIa and a pseudogene related to the COXVIa-L cDNA. Gene 140, 179–186.

    Article  PubMed  CAS  Google Scholar 

  • Murakami, T., Shimomura, Y., Yoshimura, A., Sokabe, M. and Fujitsuka, N. (1998) Induction of nuclear respiratory factor-1 expression by an acute bout of exercise in rat muscle. Biochim. Biophys. Acta 1381, 113–122.

    PubMed  CAS  Google Scholar 

  • Nie, F. and Wong-Riley, M. (1999) Nuclear respiratory factor-2 subunit protein: Correlation with cytochrome oxidase and regulation by functional activity in the monkey primary visual cortex. J. Comp. Neurol. 404, 310–320.

    Article  PubMed  CAS  Google Scholar 

  • Nisoli, E., Clementi, E., Paolucci, C., Cozzi, V., Tonello, C., Sciorati, C., Bracale, R., Valerio, A., Francolini, M., Moncada, S. and Carruba, M.O. (2003) Mitochondrial biogenesis in mammals: the role of endogenous nitric oxide. Science 299, 896–899.

    Article  PubMed  CAS  Google Scholar 

  • Okuno, H., Kanou, S., Tokuyama, W., Li, Y.X. and Miyashita, Y. (1997) Layer-specific differential regulation of transcription factors Zif268 and Jun-D in visual cortex V1 and V2 of macaque monkeys. Neurosci. 81, 653–666.

    Article  CAS  Google Scholar 

  • Ongwijitwat, S. and Wong-Riley, M.T.T. (2004) Functional analysis of the rat cytochrome c oxidase subunit 6A1 promoter in primary neurons. Gene 337, 163–171.

    Article  PubMed  CAS  Google Scholar 

  • Ongwijitwat, S. and Wong-Riley, M.T.T. (2005) Is nuclear respiratory factor 2 a master transcriptional coordinator for all ten nuclear-encoded cytochrome c oxidase subunits in neurons? Gene 360, 65–77.

    Article  PubMed  CAS  Google Scholar 

  • Ongwijitwat, S., Liang, H.L., Graboyes, E.M. and Wong-Riley, M.T.T. (2006) Nuclear respiratory factor 2 senses changing cellular energy demands and its silencing down-regulates cytochrome oxidase and other target gene mRNAs. Gene 374, 39–49.

    Google Scholar 

  • Parisi, M.A. and Clayton, D.A. (1991) Similarity of human mitochondrial transcription factor 1 to high mobility group proteins. Science 252, 965–969.

    Article  PubMed  CAS  Google Scholar 

  • Puigserver, P., Wu, Z., Park, C.W., Graves, R., Wright, M. and Spiegelman, B.M. (1998) A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell 92, 829–839.

    Article  PubMed  CAS  Google Scholar 

  • Puigserver, P., Adelmant, G., Wu, Z., Fan, M., Xu, J., O’Malley, B. and Spiegelman, B.M. (1999) Activation of PPARgamma coactivator-1 through transcription factor docking. Science 286, 1368–1371.

    Article  PubMed  CAS  Google Scholar 

  • Puigserver, P. and Spiegelman, B.M. (2003) Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator. Endocr. Rev. 24, 78–90.

    Article  PubMed  CAS  Google Scholar 

  • Scarpulla, R.C. (1997) Nuclear control of respiratory chain expression in mammalian cells. J. Bioenerg. Biomemb. 29, 109–119.

    Article  CAS  Google Scholar 

  • Scarpulla, R.C. (2002) Nuclear activators and coactivators in mammalian mitochondrial biogenesis. Biochim. Biophys. Acta 1576, 1–14.

    PubMed  CAS  Google Scholar 

  • Scarpulla, R.C. (2006) Nuclear control of respiratory gene expression in mammalian cells. J. Cell Biochem. 97, 673–683.

    Article  PubMed  CAS  Google Scholar 

  • Seelan, R.S. and Grossman, L.I. (1997) Structural organization and promoter analysis of the bovine cytochrome c oxidase subunit VIIc gene. A functional role for YY1. J. Biol. Chem. 272, 19175–10181.

    Google Scholar 

  • Seelan, R.S., Gopalakrishnan, L., Scarpulla, R.C. and Grossman, L.I. (1996) Cytochrome c oxidase subunit VIIa liver isoform. Characterization and identification of promoter elements in the bovine gene. J. Biol. Chem. 271, 2112–2120.

    Article  PubMed  CAS  Google Scholar 

  • Short, K.R., Vittone, J.L., Bigelow, M.L., Proctor, D.N., Rizza, R.A., Coenen-Schimke, J.M. and Nair, K.S. (2003) Impact of aerobic exercise training on age-related changes in insulin sensitivity and muscle oxidative capacity. Diabetes 52, 1888–1896.

    Article  PubMed  CAS  Google Scholar 

  • Smith, E.O. and Lomax, M.I. (1993) Structural organization of the bovine gene for the heart/muscle isoform of cytochrome c oxidase subunit VIa. Biochim. Biophys. Acta 1174, 63–71.

    PubMed  CAS  Google Scholar 

  • Sucharov, C., Basu, A., Carter, R.S. and Avadhani, N.G. (1995) A novel transcriptional initiator activity of the GABP factor binding ets sequence repeat from the murine cytochrome c oxidase Vb gene. Gene Expr. 5, 93–111.

    PubMed  CAS  Google Scholar 

  • Takata, K., Inoue, Y.H., Hirose, F., Murakami, S., Shimanouchi, K., Sakimoto, I. and Sakaguchi, K. (2003) Spatio-temporal expression of Drosophila mitochondrial transcription factor A during development. Cell Biol. Int. 27, 361–374.

    Article  PubMed  CAS  Google Scholar 

  • Thompson, C.C., Brown, T.A. and McKnight, S.L. (1991) Convergence of Ets- and Notch-related structural motifs in a heteromeric DNA binding complex. Science 253, 762–768.

    Article  PubMed  CAS  Google Scholar 

  • Tritos, N.A., Mastaitis, J.W., Kokkotou, E.G., Puigserver, P., Spiegelman, B.M. and Maratos-Flier, E. (2003) Characterization of the peroxisome proliferators activated receptor coactivator 1 alpha (PGC 1α ) expression in the murine brain. Brain Res. 961, 255–260.

    Article  PubMed  CAS  Google Scholar 

  • Virbasius, J.V. and Scarpulla, R.C. (1991) Transcriptional activation through ETS domain binding sites in the cytochrome c oxidase subunit IV gene. Mol. Cell Biol. 11, 5631–5638.

    PubMed  CAS  Google Scholar 

  • Virbasius, J.V. and Scarpulla, R.C. (1994) Activation of the human mitochondrial transcription factor A gene by nuclear respiratory factors: a potential regulatory link between nuclear and mitochondrial gene expression in organelle biogenesis. Proc. Natl. Acad. Sci. USA 91, 1309–1313.

    Article  PubMed  CAS  Google Scholar 

  • Virbasius, J.V., Virbasius, C.A. and Scarpulla, R.C. (1993) Identity of GABP with NRF-2: a multisubunit activator of cytochrome oxidase expression, reveals a cellular role for an ETS domain activator of viral promoters. Gene Dev. 7, 380–392.

    Article  PubMed  CAS  Google Scholar 

  • Virbasius, C.A., Virbasius, J.V. and Scarpulla, R.C. (1993b) NRF-1, an activator involved in nuclear-mitochondrial interaction, utilizes a new DNA-binding domain conserved in a family of developmental regulators. Gene Dev. 7, 2431–2445.

    Article  CAS  Google Scholar 

  • Wong-Riley, M.T.T. (1989) Cytochrome oxidase: an endogenous metabolic marker for neuronal activity. Trends Neurosci. 12, 94–101.

    Article  PubMed  CAS  Google Scholar 

  • Wong-Riley, M.T.T., Mullen, M.A., Huang, Z. and Guyer, C. (1997) Brain cytochrome oxidase subunit genes: Isolation, subcloning, sequencing, light and EM in situ hybridization of transcripts, and regulation by neuronal activity. Neurosci. 79, 1035–1055.

    Article  Google Scholar 

  • Wong-Riley, M.T.T., Nie, F., Hevner, R.F. and Liu, S. (1998) Brain cytochrome oxidase: Functional significance and bigenomic regulation in the CNS. In: F. Gonzalez-Lima (Ed.) Cytochrome oxidase in neuronal metabolism and Alzheimer’s Disease. Plenum Press, New York, PP 1–53.

    Google Scholar 

  • Wong-Riley, M.T.T., Guo, A., Bachman, N.J. and Lomax, M.I. (2000) Human COX6A1gene: promoter analysis, cDNA isolation and expression in the monkey brain. Gene 247, 63–75.

    Article  PubMed  CAS  Google Scholar 

  • Wong-Riley, M.T.T., Yang, S.J., Liang, H.L., Ning, G. and Jacobs, P. (2005) Quantitative immuno-electron microscopic analysis of nuclear respiratory factor 2 alpha and beta subunits: Normal distribution and activity-dependent regulation in mammalian visual cortex. Visual Neurosci. 22, 1–18.

    Article  Google Scholar 

  • Wu, Z., Puigserver, P., Andersson, U., Zhang, C., Adelmant, G., Mootha, V., Troy, A., Cinti, S., Lowell, B., Scarpulla, R.C. and Spiegelman, B.M. (1999) Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1. Cell 98, 115–124.

    Article  PubMed  CAS  Google Scholar 

  • Xia, Y., Buja, L.M., Scarpulla, R.C. and McMillin, J.B. (1997) Electrical stimulation of neonatal cardiomyocytes results in the sequential activation of nuclear genes governing mitochondrial proliferation and differentiation. Proc. Natl. Acad. Sci. USA, 94, 11399–11404.

    Google Scholar 

  • Yang, S.J., Liang, H.L., Ning, G. and Wong-Riley, M.T.T. (2004) Ultrastructural study of depolarization-induced translocation of NRF-2 transcription factor in cultured rat visual cortical neurons. Eur. J. Neurosci. 19, 1153–1162.

    Google Scholar 

  • Yang, S.J., Liang, H.L. and Wong-Riley, M.T.T. (2006) Activity-dependent transcriptional regulation of nuclear respiratory factor-1 in cultured rat visual cortical neurons. Neurosci. 141, 1181–1192.

    Article  CAS  Google Scholar 

  • Zhang, C., Wong-Riley, M. (2000) Depolarization stimulation upregulates GA-binding protein in neurons: a transcription factor involved in the bigenomic expression of cytochrome oxidase subunits. Eur. J. Neurosci. 12, 1013–1023.

    Article  PubMed  CAS  Google Scholar 

Download references

Authors
  1. Margaret T.T. Wong-Riley
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Huan Ling Liang
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Sakkapol Ongwijitwat
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Laboratory of Neurobiology, Synaptic & Developmental Plasticity Group NIEHS/NIH, Research Triangle Park, NC 27709, USA

    Serena M. Dudek

Rights and permissions

Reprints and permissions

Copyright information

© 2008 Springer Science+Business Media, LLC

About this chapter

Cite this chapter

Wong-Riley, M.T., Liang, H.L., Ongwijitwat, S. (2008). Activity-Dependent Bigenomic Transcriptional Regulation of Cytochrome c Oxidase in Neurons. In: Dudek, S.M. (eds) Transcriptional Regulation by Neuronal Activity. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-73609-9_11

Download citation

Publish with us

Policies and ethics

Search

Navigation