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Acute Neuronal Injury pp 79–88Cite as

Excitotoxic Programmed Cell Death Involves Caspase-Independent Mechanisms

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Abstract

Excitotoxicity is a common pathological process in many neurodegenerative disorders; and this process involves over-stimulation of glutamate receptors and an excessive influx of calcium into cells. Cell death in excitotoxicity is unique in that it does not involve caspase dependent pathways. Overactivation of poly (ADP-ribose) polymerase-1 (PARP-1) is an early pathological event in excitotoxicity that leads to a unique form of cell death called parthanatos. Biochemical events in parthanatos include early accumulation of poly (ADP-ribose) (PAR) and nuclear translocation of apoptosis inducing factor (AIF) from the mitochondria.

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Acknowledgements

We thank K. Quinn Tyler for editorial assistance. This work was supported by USPHS NS039148, DA000266. TMD is the Leonard and Madlyn Abramson Professor in Neurodegenerative Diseases.

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Authors and Affiliations

  1. Institute For Cell Engineering, Johns Hopkins University School of Medicine, 733 North Broadway, BRB731, Baltimore, MD, 21205, USA

    Ho Chul Kang, Ted M. Dawson & Valina L. Dawson

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  1. Ho Chul Kang
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  2. Ted M. Dawson
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  3. Valina L. Dawson
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Correspondence to Ho Chul Kang .

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  1. Healthcare System, VA Greater Los Angeles, Plummer St. 16111, North Hills, 91343, U.S.A.

    Denson G. Fujikawa

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Kang, H.C., Dawson, T.M., Dawson, V.L. (2010). Excitotoxic Programmed Cell Death Involves Caspase-Independent Mechanisms. In: Fujikawa, D. (eds) Acute Neuronal Injury. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-73226-8_5

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