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Parameters for Carbamate Pesticide QSAR and PBPK/PD Models for Human Risk Assessment

  • Chapter
Reviews of Environmental Contamination and Toxicology

Part of the book series: Reviews of Environmental Contamination and Toxicology ((RECT,volume 193))

Abstract

Our interest in providing parameters for the development of quantitative structure physiologically based pharmacokinetic/pharmacodynamic (QSPBPK/PD) models for assessing health risks to carbamates (USEPA 2005) comes from earlier work with organophosphorus (OP) insecticides (Knaak et al. 2004). Parameters specific to each carbamate are needed in the construction of PBPK/PD models along with their metabolic pathways. Parameters may be obtained by (1) development of QSAR models, (2) collecting pharmacokinetic data, and (3) determining pharmacokinetic parameters by fitting to experimental data. The biological parameters are given in Table 1 (Blancato et al. 2000).

Biological Parameters Required for Carbamate Pesticide Physiologically Based Pharmacokinetic/Pharmacodynamic (PBPK/PD) Models.a

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Authors and Affiliations

  1. Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, SUNY at Buffalo, 3435 Main Street, Buffalo, NY, 14214, USA

    James B. Knaak

  2. U.S. Environmental Protection Agency, Human Exposure and Atmospheric Sciences Division, 944 E Harmon Ave, Las Vegas, NV, 89193-3478, USA

    Curt C. Dary, Miles S. Okino & Fred W. Power

  3. General Dynamics Information Technology, 181 N Arroyo Grande Blvd, Suite 105, Henderson, NV, 89074-1624, USA

    Xiaofei Zhang & Carol B. Thompson

  4. U.S. Environmental Protection Agency, National Exposure Research Laboratory, Mail Code: D305-01, Research Triangle Park, NC, 27711, USA

    R. Tornero-Velez & Jerry N. Blancato

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    David M. Whitacre

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Communicated by James B. Knaak.

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Knaak, J.B. et al. (2008). Parameters for Carbamate Pesticide QSAR and PBPK/PD Models for Human Risk Assessment. In: Whitacre, D.M. (eds) Reviews of Environmental Contamination and Toxicology. Reviews of Environmental Contamination and Toxicology, vol 193. Springer, New York, NY. https://doi.org/10.1007/978-0-387-73163-6_3

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