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Biophysical Aspects of Actin-Based Cell Motility in Fish Epithelial Keratocytes

  • Kinneret Keren
  • Julie A. Theriot
Part of the Biological and Medical Physics, Biomedical Engineering book series (BIOMEDICAL)

Summary

Cell motility is a fascinating dynamic process crucial for a wide variety of biological phenomena, including defense against injury or infection, embryogenesis, and cancer metastasis. A cell using actin-based motility to crawl across a substrate must coordinate the action of numerous individual molecular building blocks to achieve coherent cell movement. While the molecular basis of cell motility is beginning to be understood, relatively little is known about the large-scale mechanisms responsible for this remarkable self-organization that bridges many orders of magnitude in both space and time. In this chapter, we discuss the biophysical aspects of actin-based cell motility and the importance of their interplay with the underlying biochemical processes, focusing on fish epithelial keratocytes as a relatively simple model system. We review the current understanding regarding the mechanical and biochemical aspects of keratocyte motility, and at the same time highlight some gaps in our knowledge.

Keywords

Cell Motility Actin Polymerization Actin Network Membrane Tension Actin Monomer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Kinneret Keren
    • 1
  • Julie A. Theriot
    • 1
    • 2
  1. 1.Department of BiochemistryStanford UniversityStanfordUSA
  2. 2.Department of Microbiology and ImmunologyStanford UniversityStanfordUSA

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