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References
Davies, D.F., Shock, N.W. Age changes in glomerular filtration rate, effective renal plasma flow, and tubular excretory capacity in adult males. J. Clin. Invest. 1950; 29:490–507.
Berglund, F. Urinary excretion patterns for substances with simultaneous secretion and reabsorption by active transport. Acta Physiol. Scand. 1961; 52:276–290.
Namnun, P., Insogna, K., Baggish, D., Hayslett, J.P. Evidence for bidirectional net movement of creatinine in the rat kidney. Am. J. Physiol. 1983; 224:F719–F723.
Lee, K.E., Behrendt, G., Kaczmarczyk, G., Mohnhaupt, R., Reindhart, H.W. Estimation of glomerular filtration rate in conscious dogs following a bolus of creatinine. Pflügers Arch. 1983; 396:176–178.
Sjostrom, P.A., Odlind, B.G., Wolgast, M. Extensive tubular secretion and reabsorption of creatinine in humans. Scand. J. Urol. Nephrol. 1988; 22(2):129–131.
Macías-Núñez, J.F., Garcia Iglesias, C., Tabernero Romo, J., Bondia, A., Rodriguez Commes, J.L., Corbacho, L., Martin, M., De Pablo, F., De Castro, S. Estudio del filtrado glomerular en viejos sanos. Rev. Esp. Geriatr. Gerontol. 1981; 16(2):113–124.
Smith, H.W. The Kidney, Structure and Function in Health and Disease. New York: Oxford University Press. 1957; pp. 39–63, 182–194.
Guyton, A.G., Hall, J.E. Textbook of Medical Physiology. Philadelphia: WB Saunders. 1996; p. 348.
Kimmel, P.L., Lew, S.Q., Bosch, J.P. Nutrition, ageing and GFR: Is age-associated decline inevitable? Nephrol., Dial., Transplant. 1996; 11:85–87.
Lindeman, R.D. Overview: Renal physiology and pathophysiology of aging. Am. J. Kidney Dis. 1990; 16:275–282.
Larsson, M., Jagenburg, R., Landahl, S. Renal function in an elderly population. Scand. J. Clin. Lab. Invest. 1986; 46:593–598.
Kampmann, J., Siersbaek-Nielsen, K., Kristensen, K., Molholm-Hansen, J. Rapid evaluation of creatinine clearance. Acta Med. Scand. 1974; 196:517–520.
Rowe, J.W., Shock, N., De Fronzo, R.A. The influence of age on the renal response to water deprivation in man. Nephron 1976; 17:270–278.
Cockroft, D.W., Gault, M.N. Prediction of creatinine clearance from serum creatinine. Nephron 1976; 16:31–41.
Nicholl, S.R., et al. Assessment of creatinine clearance in healthy subjects over 65 years of age. Nephron 1991; 59:621–625.
Keller, F. Kidney function and age (letter). Nephrol., Dial., Transplant. 1087; 2:382.
Nankivell, B.J., Gruenwald, S.M., Allen, R.D., Chapman, J.R. Predicting glomerular filtration rate after kidney transplantation. Transplant. 1995; 59:1683–1689.
Baracskay, K., Jarjoura, D., Cugino, A., et al. Geriatric renal function: Estimating glomerular filtration in an ambulatory elderly population. Clin. Nephrol. 1997; 47:222–228.
Levey, A.S., Bosch, J.P., Lewis, J.B., Greene, T., Rogers, N., Roth, D. A more accurate method to estimate glomerular filtration rate from serum creatinine: A new prediction equation. Ann. Intern. Med. 1999; 130:461–470.
Rule, A.D., Jacobsen, S.J., Schwartz, G.L., Mosley, T.H., Scott, C.G., Kardia, S.L., Boerwinkle, E., Turner, S.T. A comparison of serum creatinine-based methods for identifying chronic kidney diseases in hypertensive individuals and their siblings. A.J.H. 2006; 19:608–661.
Musso, C., Macías-Núñez, J.F., Oreopoulos, D.G. The aged kidney and the chronically aged one. Ann. Intern. Med. Oct. 4, 2006 (letter, in press).
Durakovic, Z. Creatinine clearance in the elderly: A comparison of direct measurement and calculation from serum creatinine. Nephron 1986; 44:66–69.
Xu, X., Zou, J., Ding, X., Xin, D., Ren, Y. Clinical value of serum cystatin-C by Elisa for estimation of glomerular filtration rate. J. Clin. Lab. Anal. 2004; 18(2):61–64.
Knigt, E.L., Verhave, J.C., Spiegelman, D., Hillege, H., De Zeeuw, D., Curham, G.C., De Jong, P.E. Factors influencing serum cystatin-C levels other than renal function and the impact on renal function measurement. Kidney Int. 2004; 65:1416–1421.
Shemesh, O., Golbetz, H., Kriss, J.P., Myers, B.D. Limitations of creatinine as a filtration marker in glomerulopathic patients. Kidney Int. 1985; 28(5):830–838.
Larsson, A., Helmersson, J., Hansson, L.O., Basu, S. Increased serum cystatin-C is associated with increased mortality in elderly men. Scand. J. Clin. Invest. 2005; 65(4):301–305.
De Santo, N., Anastasio, P., Coppola, S., Barba, G., Jadanza, A., Capasso, G. Age-related changes in renal reserve and renal tubular function in healthy humans. Child Nephrol. Urol. 1991; 11:33–40.
Macías-Núñez, J.F., et al. Renal handling of sodium in old people: A functional study. Age and Ageing 1978; 7:178–181.
Macías-Núñez, J.F., Cameron, J.S. The ageing kidney. In Oxford Textbook of Clinical Nephrology, 3rd ed. A.M. Davison, J.S. Cameron, J.P. Grünfeld et al., eds. Oxford: Oxford University Press. 2005; pp. 73–85.
Musso, C., López-Novoa, J.M., Macías-Núñez, J.F. Handling of water and sodium by the senescent kidney. Interpretation of a clearance technique for functional study. Rev. Esp. Ger. 2005; 40(2):114–119.
Burg, M.B. The renal handling of sodium chloride. In The Kidney, B.M. Brenner and F.C. Rector, eds. Oxford: Saunders. 1976; pp. 272–298.
Refoyo, A., Macías-Núñez, J.F. The maintenance of sodium in healthy aged. Geriatr. Nephrol. Urol. 1991; 1:65–68.
You, G., Smith, C.P., Kanay, Y., et al. Cloning and expression of the vasopressin-regulated urea transporter. Nature 1993; 365–844.
Dontas, A.S., Marketos, S., Papanayioutou, P. Mechanisms of renal tubular defects in old age. Postgraduate Med. J. 1972; 48:295–303.
Lewis, W.H., Alving, A.S. Changes with age in the renal function of adult men. Clearance of urea, amount of urea nitrogen in the blood, concentrating ability of kidneys. Am. J. Physiol. 1938; 123:505–515.
Kirkland, J.L., Lye, M., Levy, D.W., Banerjee, A.K. Patterns of urine flow and electrolyte secretion in healthy elderly people. Br. Med. J. 1985; 285:1665–1667.
Kleeman, C.R. Water metabolism. In Clinical Disorders of Fluid and Electrolyte Balance, M.H. Maxwell and C.R. Kleeman, eds. New York: McGraw-Hill. 1972; p. 697.
Takazakura, E., Sawabu, N., Handa, A., Takada, A., Shinada, A., Takeuchi, J. Intrarenal vascular change with age and disease. Kidney Int. 1972; 2:224–230.
Hollenberg, N.K., Adams, D.F., Solomon, H.S., Rashid, A., Abrams, H.L., Merrill, J.P. Senescence and the renal vasculature in normal man. Circ. Res. 1974; 34:309–316.
Crowe, M.J., Forsling, M.L., Philips, P.A., Ledinghan, J.G., Smith, R.F. Altered water excretion in healthy elderly men. Age and Ageing 1987; 16:285–293.
Hiraide, K. Alterations in electrolytes with aging. Nihon Univ. J. Med. 1981; 23:21–31.
Lye, M. Distribution of body potassium in healthy elderly subjects. Gerontology 1981; 27:286.
Kromhout, D., Broberg, U., Carlmark, B., Karlsson, S., Nissel, O., Reizenstein, P. Potassium depletion and ageing. Comprehensive Therapeutics 1977; 3:32–37.
Burini, R., Da Silva, C.A., Ribeiro, M.A.C., Campana, A.D. Concentraçao de sodio e de potassio no soro e plasma de individuos normais. Influencia da idade, do sexo e do sistema de colheita do sangue sobre os resultados. Revista de Hospitale Clinico da Facultad do Medicina de Saõ Paulo 1973; 28:9–14.
Macías-Núñez, J.F., García-Iglesias, C., Tabernero-Romo, J.M., Rodríguez-Commes, J.L., Corbacho-Becerra, L., Sanchez-Tomero, J.A. Renal management of sodium under indomethacin and aldosterone in the elderly. Age and Ageing 1980; 9:165–172.
Biswas, K., Mulkerrin, E.C. Potassium homoeostasis in the elderly. Quar. J. Med. 1997; 90:487–492.
Rodriguez-Puyol, D. The aging kidney. Kidney Int. 1998; 54:2247–2265.
Musso, C.G., Musso, C.A., Joseph, H., De Miguel, R., Rendo, P., Gonzalez, E., Algranati, L., dos Ramos Farias, E. Plasma erythropoietin levels in the oldest old. Int. Urol. Nephrol. 2004; 36(2):259–262.
Musso, C., Liakopoulos, V., De Miguel, R., Imperiali, N., Algranati, L. Transtubular potassium concentration gradient: Comparison between healthy old people and chronic renal failure patients. Int. Urol. Nephrol. 2006; 38:387–390.
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Macías-Núñez, JF., López-Novoa, J.M. (2008). Physiology of the Healthy Aging Kidney. In: MachasNúñez, J.F., Cameron, J.S., Oreopoulos, D.G. (eds) The Aging Kidney in Health and Disease. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-72659-5_5
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