Acute Renal Failure in the Aged

  • Carlos G. Musso
  • José M. López-Novoa
  • José Carlos Fernandez
  • Juan-Florencio Macías-Núñez


Acute Renal Failure Fractional Excretion Renal Blood Flow Hemolytic Uremic Syndrome Acute Tubular Necrosis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Lameire, N. Recent advances in clinical acute renal failure. Rev. Port. Hipert. 2005; 19(1):15–30.Google Scholar
  2. 2.
    Macías-Núñez, J.F., Sanchez Tomero, J.A. Acute renal failure in old people. In Renal Function and Disease in the Elderly, J.F. Macías-Núñez and S. Cameron, eds. London: Butterworth. 1987; pp. 461–484.Google Scholar
  3. 3.
    Brady, H.R., Clarckson, M.R., Lieberthal, W. Acute renal failure. In The Kidney, B. Brenner, ed. Philadelphia: Saunders. 2005; pp. 1215–1292.Google Scholar
  4. 4.
    Racusen, L.C. The morphologic basis of acute renal failure. In Acute Renal Failure: A Comparison to Brenner and Rectorś The Kidney, B.A. Molitoris and W.F. Finn, eds. Philadelphia: W.B. Saunders. 2001; pp. 1–12.Google Scholar
  5. 5.
    Stein, J.H., Lifschitz, B.D., Barnes, L.D. Current concepts on the pathophysiology of acute renal failure. Am. J. Physiol. 1978; 234:F171–181.PubMedGoogle Scholar
  6. 6.
    Solez, K. The morphology of acute renal failure. In Acute Renal Failure, J.M. Lazarus and B.M. Brenner, eds. New York. Churchill Livingstone. 1993; pp. 33–51.Google Scholar
  7. 7.
    Solez, K., Altman, J., Rienhoff, H., et al. Early angiographic and renal blood flow changes after HgCl2 or glycerol administration. Kidney Int. 1976; 10:S153–S159.Google Scholar
  8. 8.
    Rodriguez Mañas, L. Aging and the vascular wall. Circulation 2000; 104: 2638–2640.Google Scholar
  9. 9.
    Avasthi, P., Evan, A.P., Hay, D. Glomerular endothelial cells in uranyl nitrate-induced acute renal failure in rats. J. Clin. Invest. 1980; 65:121–127.PubMedGoogle Scholar
  10. 10.
    Schor, N., Ichikawa, I., Rennke, H.G., et al. Pathophysiology of altered glomerular function in aminoglycoside-treated rats. Kidney Int. 1981; 19:288–296.PubMedCrossRefGoogle Scholar
  11. 11.
    Flamenbaum, W., McNeil, J.S., Kotchen, T.W., Saladino, A.J. Experimental acute renal failure induced by uranyl nitrate in the dog. Circ. Res. 1972; 31:682–698.PubMedGoogle Scholar
  12. 12.
    Venkatachalam, M.A., Bernard, B.D., Donohoe, J.F., Levinsky, N.G. Ischemic damage and repair in the rat proximal tubule: Differences among the S1, S2 and S3 segments. Kidney Int. 1978; 14:31–49.PubMedCrossRefGoogle Scholar
  13. 13.
    Lameire, N.H., Vanholder, R.C. Acute renal failure: Pathophysiology and prevention. In Oxford Textbook of Clinical Nephrology, A. Davison, J.S. Cameron, J.P. Grünfeld, C. Ponticelli, E. Ritz, C.G. Winearls, and C. Van Ypersele, eds. Oxford: Oxford University Press. 2005; pp. 1445–1464.Google Scholar
  14. 14.
    Donohoe, J.F., Venkatachalam, M.A., Bernard, D.B., Levinsky, N.G. Tubular leakage and obstruction after renal ischemia: Structure-function correlations. Kidney Int. 1978; 13:208–222.PubMedCrossRefGoogle Scholar
  15. 15.
    Goormaghtigh, N. Existence of an endocrine gland in the arteriolar media of renal arterioles. Proc. Soc. Exp. Biol. Med. 1939; 42:688–689.Google Scholar
  16. 16.
    López-Novoa, J.M., Casado, S., Hernando, L. Protection by propanolol againstGoogle Scholar
  17. 17.
    glycerol-induced acute renal failure. Role of extracellular volume expansion. Biomedicina 1978; 29:303–306.Google Scholar
  18. 18.
    López-Novoa, J.M. Potential role of platelet activating factor in acute renal failure. Kidney Int. 1999; 55:1672–1682.PubMedCrossRefGoogle Scholar
  19. 19.
    Martínez-Salgado, C., Rodríguez-Barbero, A., Rodríguez-Puyol, D., Pérez de Lema, G., López-Novoa, J.M. Involvement of phospholipase A2 in gentamicin-induced rat mesangial cell activation. Am. J. Physiol. 1997; 273:F60–F66.PubMedGoogle Scholar
  20. 20.
    Werb, R., Clark, W.F., Lindsay, R.M., et al. Protective effect of prostaglandin (PGE2) in glycerol-induced acute renal failure in rats. Clin. Sci. Mol. Med. 1978; 55:505–507.PubMedGoogle Scholar
  21. 21.
    Mauk, R.H., Patak, R.V., Fadem, S.Z., et al. Effect of prostaglandin E administration in a nephrotoxic and a vasoconstrictor model of acute renal failure. Kidney Int. 1977; 12:122–130.PubMedCrossRefGoogle Scholar
  22. 22.
    Perez del Villar, C., Garcia Alonso, C.J., Feldstein, C.A., Juncos, L.A., Romero, J.C. Role of endothelin in the pathogenesis of hypertension. Mayo Clin. Proc. 2005; 80:84–96.PubMedGoogle Scholar
  23. 23.
    Garcia, R.E. Therapeutic strategies in the prevention of acute renal failure. Ren. Fail. 1997; 19:231–235.PubMedCrossRefGoogle Scholar
  24. 24.
    Tsau, Y.K., Tsai, W.S., Chen, C. Urinary entothelin-1 in children with acute renal failure of tubular origin. J. Fromo. Med. Assoc. 1998; 97:387–391.Google Scholar
  25. 25.
    Macías-Núñez, J.F., García Iglesias, C., Santos, J.C., Villamediana, L.M., López-Novoa, J.M. Influence of plasma renin content, intrarenal angiotensin II, captopril and calcium channel blockers on the vasoconstriction and renin release promoted by adenosine in the kidney. J. Lab. Clin. Med. 1985; 106:562–567.PubMedGoogle Scholar
  26. 26.
    Kolonko, A., Wiecek, A., Kokot, F. The nonselective adenosine antagonist theophylline does prevent renal dysfunction induced by radiographic contrast agents. J. Nephrol. 1998; 11:151–156.PubMedGoogle Scholar
  27. 27.
    Valdivielso, J.M., Rivas Cabañero, L., Perez-Barriocanal, F., López-Novoa, J.M. Effect of nitric oxide synthesis modification on renal function in gentamicin-induced nephrotoxicity. Env. Toxicol. Pharmacol. 1997; 3:123–128.CrossRefGoogle Scholar
  28. 28.
    Musso, C.G. Acute renal failure in the elderly: Pearls for its assessment and treatment. Scholar
  29. 29.
    Lameire, N., Nelde, A., Hoeben, H., Vanholder, R. Acute renal failure in the elderly. In Nephrology and Geriatrics Integrated, D. Oreopoulos, W. Hazzard, and R. Luke, eds. Dordrecht: Kluwer Academic Publishers. 2000; pp. 93–111.Google Scholar
  30. 30.
    Fillit, H., Mayer, L., Bona, C.A. Immunology of aging. In Textbook of Geriatric Medicine and Gerontology, J.C. Brocklehurst, R.C. Tallis, and H. Fillit, eds. New York: Churchill-Livingstone. 1992; pp. 71–90.Google Scholar
  31. 31.
    Pascual , J., Ordónez, O., Liaño, F. Fracaso renal agudo en el anciano. In Fracaso Renal Agudo, F. Liaño and J. Pascal, eds. [in Spanish] Barcelona: Masson. 2002; pp. 369–382.Google Scholar
  32. 32.
    Beck, L.H. Changes in renal function with aging. Clin. Geriatr. Med. 1998; 11:199–209.Google Scholar
  33. 33.
    Hernando Avendaño, L., López-Novoa, J. Glomerular filtration and renal blood flow in the aged. In Renal Function and Disease in the Elderly, J.F. Macías-Núñez and S. Cameron, eds. London: Butterworth. 1987; pp. 27–48.Google Scholar
  34. 34.
    Musso, C.G. Geriatric nephrology and the “nephrogeriatric giants.” Int. Urol. Nephrol. 2002; 34:255–256.PubMedCrossRefGoogle Scholar
  35. 35.
    Macías-Núñez, J.F., García Iglesias, C., Bondía Román, A., Rodríguez Commes, J.L., et al. Renal handling of sodium in old people: A functional study. Age and Ageing 1978; 7:178–181.PubMedCrossRefGoogle Scholar
  36. 36.
    Macías-Núñez, J.F., Musso, C.G. Renal physiology in the oldest old: The Sphinx remakes her question. Int. Nephrol. Urol.(in publication).Google Scholar
  37. 37.
    Macías-Núnez, J.F., López-Novoa, J.M., Martinez-Maldonado, M. Acute renalGoogle Scholar
  38. 38.
    failure in the aged. Sem. Nephrol. 1996; 16:330–338.Google Scholar
  39. 39.
    Spangler, P.F., Risley, T.R., Bilyew, D.D. The management of dehydration and incontinence in non-ambulatory geriatric patients. J. Appl. Behav. Anal. 1984; 17:397–401.PubMedCrossRefGoogle Scholar
  40. 40.
    Jerkic, M., Vojvodic, S., López-Novoa, J.M. The mechanism of increased renal susceptibility to toxic substances in the elderly. Part I. The role of increased vasoconstriction. Int. Urol. Nephrol. 2001; 32(4):539–547.PubMedCrossRefGoogle Scholar
  41. 41.
    Lameire, N., Matthys, E., Vanholder, R., De Keyser, K., Pauwels, W., Nachtergaele, H., Lambrecht, L., Ringoir, S. Causes and prognosis of acute renal failure in the elderly. Nephrol. Dial. Transplant 1987; 2:316–322.PubMedGoogle Scholar
  42. 42.
    Lameire, N., Verspeelt, J., Vanholder, R., Ringoir, S. A review of the pathophysiology, causes and prognosis of acute renal failure in the elderly. Geriatr. Nephrol. Urol. 1991; 1:77–91.CrossRefGoogle Scholar
  43. 43.
    Dixon, B.S., Anderson, R.J. Nonoliguric acute renal failure. Am. J. Kidney 1985; 6:71–80.Google Scholar
  44. 44.
    Musso, C.G. Aminoglycosides and nephropathy. 2004; 2(2): 1–3.Google Scholar
  45. 45.
    Musso, C.G. Clinical catastrophic events in geriatrics: Its physiopathological bases. Int. Nephrol. Urol. (in publication).Google Scholar
  46. 46.
    Musso, C.G., Pidoux, R., Mombelli, C., et al. Acute renal failure secondary to rhabdomyololysis induced by influenza vaccine in n old patient. www.biomed. 2005; (3).Google Scholar
  47. 47.
    Lou, L.M., Boned, B., Gomez Sanchez, R. Characteristics of acute renal failure in elderly patients admitted to a small town hospital. Nefrologia 2002; 22(6): 547–554.PubMedGoogle Scholar
  48. 48.
    Musso, C.G., Macías-Núñez, J.F. Renal diseases. In Principles and Practice of Geriatric Medicine, J.M.S. Pathy, A.J. Sinclair, and J.E. Morley, eds. Chichester: John Wiley & Sons. 2006; pp. 1495–1508.Google Scholar
  49. 49.
    Liaño, F., Gamez, C., Pascual, J., Teruel, J.L., Villafruela, J.J., Orte, L., Ortuno, J. Use of urinary parameters in the diagnosis of total acute renal artery occlusion. Nephron 1994; 66:170–175.PubMedGoogle Scholar
  50. 50.
    Pascual, J., Orofino, L., Liano, F., Marcen, R., Naya, T., Orte, L., Ortuno, J. Incidence and prognosis of acute renal failure in older patients. J. Am. Geriatr. Soc. 1990; 38:25–30.PubMedGoogle Scholar
  51. 51.
    Walsh, P.C. Benign prostatic hyperplasia. In Campbell’s Urology, 5th ed., P.C. Walsh, R.F. Gittes, A.D. Perlmutter, T.A. Stamey, and W.B. Saunders, eds. Philadelphia: 1986; pp. 1248–1265.Google Scholar
  52. 52.
    Serra, R.M., Engle, J.E., Jones, R.E., Schoolwerth, A.C. Perianeurysmal retroperitoneal fibrosis: An unusual cause of renal failure. Am. J. Med. 1980; 68:149–153.PubMedCrossRefGoogle Scholar
  53. 53.
    Wagneknecht, L.V., Hardy, I.C. Value of various treatments for retroperitoneal fibrosis. Eur. Urol. 1981; 7:193–198.Google Scholar
  54. 54.
    Maletz, R., Berman, D., Peelle, K., Bernard, D. Reflex anuria and uremia from unilateral ureteral obstruction. Am. J. Kidney Dis. 1993; 22:870–873.PubMedGoogle Scholar
  55. 55.
    Perez Almeida, E., Blanco Pascual, E. The patient with immobility syndrome. In Geriatría desde el Principio, J.F. Macías-Núñez, F.G. Guillén Llera, and J.M. Ribera Casado, eds. [in Spanish] Barcelona: Editorial Glosa. 2000; pp. 135–152.Google Scholar
  56. 56.
    Gil Gregorio, P. The patient with psychiatric alterations. In Geriatría desde el Principio, J.F. Macías-Núñez, F.G. Guillén Llera, and J.M. Ribera Casado, eds. [in Spanish] Barcelona: Editorial Glosa. 2000; pp. 183–202.Google Scholar
  57. 57.
    Musso, C.G., Macías-Núñez, J.F. The aged kidney: Structure and function. Main nephropathies. In Geriatría desde el Principio, A. Salgado, F.G. Guillén Llera, and I. Ruipérez, eds. [in Spanish] Barcelona: Masson. 2000; pp. 399–412.Google Scholar
  58. 58.
    Musso, C.G., Caceres, J.M., Luque, K., et al. Fractional excretion of urea in severe dehydrated elderly. 2005; (1).Google Scholar
  59. 59.
    Musso, C.G., Jauregui, R., et al. Low fractional excretion of urea in hypothyroidism-induced hyponatremia. 2005; (1).Google Scholar
  60. 60.
    Musso, C.G., Luque, K., Reynaldi, J., et al. Intermediate syndrome: A typical pattern of pre-renal acute renal failure in the elderly. 2004; (3).Google Scholar
  61. 61.
    Musso, C.G., Giordani, C., Stonski, E. Acute renal failure with normal plasma urea levels: A marker of proximal tubular dysfunction with diabetes insipidus. 2004; (2).Google Scholar
  62. 62.
    Musso, C.G., Vilas, M., Fernandez Otero, L., Jauregui, R., Imperiali, N.,Google Scholar
  63. 63.
    Algranati, L. Acute renal failure with normal plasma urea level secondary to acute pyelonephritis in a single kidney patient. 2006; (1).Google Scholar
  64. 64.
    Musso, C.G. El riñón del anciano, nefropatías más frecuentes y tratamiento dialítico. In A. Cusumano and O. Hermida, eds. [in Spanish] Buenos Aires. 2000.Google Scholar
  65. 65.
    Solomon, R., Werner, C., Mann, D., D’Elia, J., Silva, P. Effects of saline, mannitol and furosemide on acute decreases in renal function by radiocontrast agents. N. Engl. J. Med. 1994; 331:1414–1416.CrossRefGoogle Scholar
  66. 66.
    Pfaffle, A.E., Moses, J.W., Chan, R., Gleim, G.W., Zabetakis, P.M., Stugensky, K., Michelis, M.F. Negative fluid balance and the occurrence of radiocontrast associated acute renal failure. Geriatr. Nephrol. Urol. 1994; 4:71–77.CrossRefGoogle Scholar
  67. 67.
    Piper, S.N., Kumle, B., Boldt, J. Diltiazem may preserve renal tubular integrity after cardiac surgery. Can. J. Anaesth. 2003; 50(3):285–292.PubMedGoogle Scholar
  68. 68.
    Amis, E.S., Cronan, J.J., Pfister, R.C., Yoder, I.C. Ultrasonic inaccuracies in diagnosing renal obstruction. Urology 1982; 19:101–105.PubMedCrossRefGoogle Scholar
  69. 69.
    Rascoff, J.H., Golden, R.A., Spinowitz, B.S., Charytan, C. Non-dilated obstructive nephropathy. Arch. Intern. Med. 1983; 143:696–698.PubMedCrossRefGoogle Scholar
  70. 70.
    Lalli, A.F. Retroperitoneal fibrosis and inapparent obstructive uropathy. Radiology 1977; 122:339–342.PubMedGoogle Scholar
  71. 71.
    Musso, C., Liakopoulos, V., Ioannidis, I., Stefanidis, I. Acute renal failure in the elderly: Particular characteristics. Int. Nephrol. Urol. (in publication).Google Scholar
  72. 72.
    Cantarovich, F., Fernandez, J.C., Locatelli, A., Perez Loredo, J. Furosemide in high dose in the treatment of acute renal failure. Postgrad. Med. J. 1971; 47(Suppl): 13–17.Google Scholar
  73. 73.
    Cantarovich, F., Rangoonwala, B., Lorez, H., et al. High-dose furosemide for established ARF: A prospective, randomized, double blind, placebo controlled, multicenter trial. Am. J. Kidney Dis. 2004; 44:402–409.PubMedGoogle Scholar
  74. 74.
    Firedrich, J.O., Adhikari, N., Herridge, M.S., Beyene, J. Meta-analysis: Low-dose dopamine increases urine output but does not prevent renal dysfunction or death. Ann. Intern. Med. 2005; 142:505–524.Google Scholar
  75. 75.
    Rakowski, T.A., Winchester, J.F. Renal biopsy in the elderly patient. In Geriatric Nephrology, M.F. Michelis and H.G. Preuss, eds. New York: Field Rich. 1986; pp. 37–39.Google Scholar
  76. 76.
    Keller, F., Michaelis, C., Biitner, P., Bennhold, I., Schwarz, A., Distler, A. Risk factors for long-term survival and renal function in 64 patients with rapidly progressive glomerulonephritis (RPGN). Geriatr. Nephrol. Urol. 1994; 4:5–13.CrossRefGoogle Scholar
  77. 77.
    Baraldi, A., Ballestri, M., Rapana, R., Lucchi, L., et al. Acute renal failure of medical type in an elderly population. Nephrol. Dial. Transplant 1998; 13(Suppl 7):25–29.PubMedCrossRefGoogle Scholar
  78. 78.
    Van de Noortgate, N., Verbeke, F., Dhondt, A., Colardijn, F., et al. The dialytic management of acute renal failure in the elderly. Semin. Dial. 2002; 15(2): 127–132.PubMedCrossRefGoogle Scholar
  79. 79.
    Mandal, A.K., Baig, M., Koutoubi, Z. Management of acute renal failure in the elderly. Treatment options. Drugs Aging 1996; (4):226–250.Google Scholar
  80. 80.
    Klouche, K., Cristol, J.P., Kaaki, M., Turc-Baron, C., et al. Prognosis of acute renal failure in the elderly. Nephrol. Dial. Transplant 1995; 10(12):2240–2243.PubMedGoogle Scholar
  81. 81.
    Santacruz, F., Barreto, S., Mayor, M.M., Cabrera, W., et al. Mortality in elderly patients with acute renal failure. Ren. Fail. 1996; 18(4):601–605.PubMedCrossRefGoogle Scholar
  82. 82.
    Pascual, J., Liano, F. Causes and prognosis of acute renal failure in the very old. J. Am. Geriatr. Soc. 1998; 46(6):721–725.PubMedGoogle Scholar
  83. 83.
    Sesso, R., Roque, A., Viciosos, B., Stella, S. Prognosis of ARF in hospitalized elderly patients. Am. J. Kidney Dis. 2004; 44(3):410–419.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Carlos G. Musso
  • José M. López-Novoa
  • José Carlos Fernandez
  • Juan-Florencio Macías-Núñez

There are no affiliations available

Personalised recommendations