HIV-1 infection of central nervous system results in significant cognitive abnormalities. While underlying mechanisms of such impairment are still not completely understood, chronic neurotoxin production (pro-inflammatory factors and viral proteins) by virus-infected macrophages are considered to be the cause. A better understanding of HIV-1 neurobiology as it is driven by virus replication and anti-viral immunity will continue to drive the development of new therapeutic strategies to combat cognitive decline.
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© 2008 Springer Science+Business Media, LLC
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Persidsky, Y. (2008). NeuroAIDS. In: Gendelman, H.E., Ikezu, T. (eds) Neuroimmune Pharmacology. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-72573-4_22
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DOI: https://doi.org/10.1007/978-0-387-72573-4_22
Publisher Name: Springer, Boston, MA
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