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Molecular Pathology of Lung Diseases pp 459–469Cite as

Inflammation

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Part of the book series: Molecular Pathology Library ((MPLB,volume 1))

Abstract

In the lung, as in other anatomic sites, inflammation can be regarded as a complex, generally salutary response of the body to injurious agents. This bodily response derives from a series of interconnected cellular and molecular events acting in concert with an equally complex array of neurogenic1,2 and vasogenic factors.3–5 Principal cellular actors playing a role in the inflammatory process include polymorphonuclear leukocytes, lymphocytes, plasma cells, eosinophils, mast cells, monocytes, and macrophages. Leading molecular compounds regulating cellular responses are chemical mediators such as vasoactive amines, prostaglandins, and leukotrienes, as well as members of the kinin and complement activation system (Table 43.1).6 This chapter discusses the major forms of the inflammatory response, namely, acute and chronic inflammation, and addresses granulomatous inflammation. In addition, it covers mechanisms of response selection, innate immunity (Toll receptors), and specific cellular constituents, in particular, pulmonary alveolar macrophages and dendritic cells and their roles in antigen presentation and human leukocyte antigen (HLA)-linked diseases.

Inflammatory mediators.

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Author information

Authors and Affiliations

  1. Department of Pathology, University of Massachusetts Medical School, Worchester, MA, USA

    Armando E. Fraire MD (Professor)

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  1. Armando E. Fraire MD
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Editor information

Editors and Affiliations

  1. Department of Pathology, Penn State Milton S. Hershey Medical Center, Hershey, PA, USA

    Dani S. Zander MD

  2. Institute of Pathology, Laboratories for Molecular Cytogenetics, Medical University of Graz, Graz, Austria

    Helmut H. Popper MD

  3. Department of Pathology, University of Texas Health Science Center, San Antonio, TX, USA

    Jaishree Jagirdar MD

  4. Weill Medical College of Cornell University, New York, NY

    Abida K. Haque MD

  5. Department of Pathology, San Jacinto Methodist Hospital, Baytown, TX, USA

    Abida K. Haque MD

  6. Pathology and Laboratory Medicine, Weill Medical College of Cornell University, New York, NY

    Philip T. Cagle MD  & Roberto Barrios MD  & 

  7. The Methodist Hospital, Houston, TX, USA

    Philip T. Cagle MD  & Roberto Barrios MD  & 

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Fraire, A.E. (2008). Inflammation. In: Zander, D.S., Popper, H.H., Jagirdar, J., Haque, A.K., Cagle, P.T., Barrios, R. (eds) Molecular Pathology of Lung Diseases. Molecular Pathology Library, vol 1. Springer, New York, NY. https://doi.org/10.1007/978-0-387-72430-0_43

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  • DOI: https://doi.org/10.1007/978-0-387-72430-0_43

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-0-387-72429-4

  • Online ISBN: 978-0-387-72430-0

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