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The Agrobacterium Tumefaciens C58 Genome

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Agrobacterium: From Biology to Biotechnology

Agrobacterium is a bacterial plant pathogen capable of transferring a specific fragment of DNA, called the T-DNA, into plants and other organisms. Once in a eukaryotic cell, the T-DNA moves to the nucleus and integrates into the genome at an essentially random location. T-DNA integration generally leads to tumor formation in the plant host, and Agrobacterium’s ability to transfer DNA has been adapted as an important tool for mutagenesis and genetic engineering of plants and fungi. Agrobacterium tumefaciens C58 was the first species of Agrobacterium to have a fully-sequenced genome, and the sequence data are catalyzing expansion of A. tumefaciens research beyond its traditional focus on plant pathogenesis and T-DNA transfer. This chapter reviews many of the findings of the original genome publications and discusses many new insights derived from the availability of the genome sequence.

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Authors and Affiliations

  1. The Biodesign Institute and Department of Applied Biological Sciences, Arizona State University, Mesa, AZ 85212, USA

    Steven C. Slater

  2. Department of Biology, Hiram College, Hiram, OH 44234, USA

    Brad W. Goodner

  3. Virginia Bioinformatics Institute and Department of Computer Science, Virginia Polytechnic Institute and State University, Blacksburg, VA 24060, USA

    João C. Setubal

  4. Monsanto Company, 800 North Lindbergh Boulevard, St. Louis, MO 63167, USA

    Barry S. Goldman

  5. Department of Biology, Seattle Pacific University, Seattle, WA 98119, USA

    Derek W. Wood & Eugene W. Nester

  6. Department of Microbiology, University of Washington, Seattle, WA 98195, USA

    Derek W. Wood

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  1. Department of Molecular, Cellular and Developmental Biology, University of Michigan, 830 N. University Ave. 4071D Natural Science Building, Ann Arbor, MI 48109-1048, USA

    Tzvi Tzfira

  2. Department of Biochemistry and Cell Biology, State University of New York, Stony Brook, NY 11792-5215, USA

    Vitaly Citovsky

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Slater, S.C., Goodner, B.W., Setubal, J.C., Goldman, B.S., Wood, D.W., Nester, E.W. (2008). The Agrobacterium Tumefaciens C58 Genome. In: Tzfira, T., Citovsky, V. (eds) Agrobacterium: From Biology to Biotechnology. Springer, New York, NY. https://doi.org/10.1007/978-0-387-72290-0_4

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