An important activity of mucosal surfaces is the production of the special type of antibodies referred to as secretory IgA (SIgA) (Lamm, 1997). SIgA is produced predominantly as a dimer complexed with the J-chain and the secretory component (SC). SC is the ectodomain of the polymeric immunoglobulin receptor (pIgR) that either remains bound to polymeric IgA (pIgA) following transcytosis and proteolytic cleavage (Mostov et al., 1980) or is released alone, (i.e., free SC, in mucosal secretions) (Poger and Lamm, 1974) (see Chapter 3). The classical view is that SIgA serves as the first line of defense against microorganisms by agglutinating potential invaders and facilitating their clearance by peristaltic and mucociliary movements, a mechanism called immune exclusion (Mestecky et al., 1999).
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References
Anjuère, F., Luci, C., Lebens, M., Rousseau, D., Hervouet, C., Milon, G., Holmgren, J., Ardavin, C., and Czerkinsky, C. (2004). In vivo adjuvant-induced mobilization and maturation of gut dendritic cells after oral administration of cholera toxin. J. Immunol. 173:5103–5111.
Biesbrock, A. R., Reddy, M. S., and Levine, M. J. (1991). Interaction of a salivary mucin-secretory immunoglobulin A complex with mucosal pathogens. Infect. Immun. 59:3492–3497.
Bollinger, R. R., Everett, M. L., Palestrant, D., Love, S. D., Lin, S. S., and Parker, W. (2003). Human secretory immunoglobulin A may contribute to biofilm formation in the gut. Immunology 109:580–587.
Bollinger, R. R., Everett, M. L., Wahl, S. D., Lee, Y. H., Orndorff, P. E., and Parker, W. (2006). Secretory IgA and mucin-mediated biofilm formation by environmental strains of Escherichia coli: role of type 1 pili. Mol. Immunol. 43:378–387.
Bomsel, M., Heyman, M., Hocini, H., Lagaye, S., Belec, L., Dupont, C., and Desgranges, C. (1998). Intracellular neutralization of HIV transcytosis across tight epithelial barriers by anti-HIV envelope protein dIgA or IgM. Immunity 19:277–287.
Boren, T., Falk, P., Roth, K. A., Larson, G., and Normark, S. (1993). Attachment of Helicobacter pylori to human gastric epithelium mediated by blood group antigens. Science 262:1892–1895.
Brière, F., Paliard, X., and De Vries, J. E. (1988). Induction of the receptor for the Fc portion of IgA by secretory IgA on human T cell lines and T cell clones. Eur. J. Immunol. 18:445–450.
Brock, S. C., McGraw, P. A., Wright, P. F., Crowe, J. E., Jr. (2002). The human polymeric immunoglobulin receptor facilitates invasion of epithelial cells by Streptococcus pneumoniae in a strain-specific and cell type-specific manner. Infect. Immun. 70:5091–5095.
Cebra, J. J. (1999). Influences of microbiota on intestinal immune system development. Am. J. Clin. Nutr. 69:1046S–1051S.
Chintalacharuvu, K. R., and Morrison, S. L. (1997). Production of secretory immunoglobulin A by a single mammalian cell. Proc. Natl. Acad. Sci. USA 94:6364–6368.
Corthésy, B., Benureau, Y., Perrier, C., Fourgeux, C., Parez, N., Greenberg, H., and Schwartz-Cornil, I. (2006). Rotavirus anti-VP6 secretory IgA contributes to protection via intracellular neutralization but not via immune exclusion. J. Virol. 80:10, 692–10, 699.
Corthésy, B., Kaufmann, M., Phalipon, A., Peitsch, M., Neutra, M. R., and Kraehenbuhl, J. P. (1996). A pathogen-specific epitope inserted into recombinant secretory immunoglobulin A is immunogenic by the oral route. J. Biol. Chem. 271:33, 670–33, 677.
Costerton, J. W., Lewandowski, Z., Caldwell, D. E., Korber, D. R., and Lappin-Scott, H. M. (1995). Microbial biofilms. Annu. Rev. Microbiol. 49:711–745.
Crottet, P., and Corthésy, B. (1998). Secretory component delays the conversion of secretory IgA into antigen-binding competent F(ab’) 2: A possible implication for mucosal defense. J. Immunol. 161:5445–5453.
Cukrowska, B., Lodinova-Zadnikova, R., Enders, C., Sonnenborn, U., Schulze, J., and Tlaskalova-Hogenova, H. (2002). Specific proliferative and antibody responses of premature infants to intestinal colonization with nonpathogenic probiotic E. coli strain Nissle 1917. Scand. J. Immunol. 55:204–209.
Dallas, S. D., and Rolfe, R. D. (1998) Binding of Clostridium difficile toxin A to human milk secretory component. J. Med. Microbiol. 47:879–888.
Eberl, G. (2005). Inducible lymphoid tissues in the adult gut: recapitulation of a fetal developmental pathway? Nat. Rev. Immunol. 5:413–420.
Elm, C., Braathen, R., Bergmann, S., Frank, R., Vaerman, J. P., Kaetzel, C. S., Chhatwal, G. S., Johansen, F. E., and Hammerschmidt, S. (2004). Ectodomains 3 and 4 of human polymeric immunoglobulin receptor (hpIgR) mediate invasion of Streptococcus pneumoniae into the epithelium. J. Biol. Chem. 279:6296–6304.
Fagarasan, S., Muramatsu, M., Suzuki, K., Nagaoka, H., Hiai, H., and Honjo, T. (2002). Critical roles of activation-induced cytidine deaminase in the homeostasis of gut flora. Science 298:1424–1427.
Fagarasan, S., and Honjo, T. (2004). Regulation of IgA synthesis at mucosal surfaces. Curr. Opin. Immunol. 16:277–283.
Falk, P., Roth, K. A., Boren, T., Westblom, T. U., Gordon, J. I., and Normark, S. (1993). An in vitro adherence assay reveals that Helicobacter pylori exhibits cell lineage-specific tropism in the human gastric epithelium. Proc. Natl. Acad. Sci. USA 90:2035–2039.
Fang, H., Elina, T., Heikki, A., and Seppo, S. (2000). Modulation of humoral immune response through probiotic intake. FEMS Immunol. Med. Microbiol. 29:47–52.
Favre, L., Spertini, F., and Corthésy, B. (2005). Secretory IgA possesse intrinsic modulatory properties stimulating mucosal and systemic immune responses. J. Immunol. 175:2793–2800.
Fernandez, M. I., Pedron, T., Tournebize, R., Olivo-Marin, J. C., Sansonetti, P. J., and Phalipon. (2003). A. Anti-inflammatory role for intracellular dimeric immunoglobulin a by neutralization of lipopolysaccharide in epithelial cells. Immunity 18:739–749.
Friman, V., Adlerberth, I., Connell, H., Svanborg, C., Hanson, L. A., and Wold, A. E. (1996). Decreased expression of mannose-specific adhesins by Escherichia coli in the colonic microflora of immunoglobulin A-deficient individuals. Infect. Immun. 64:2794–2798.
Fujioka, H., Emancipator, S. N., Aikawa, M., Huang, D. S., Blatnik, F., Karban, T., DeFife, K., and Mazanec, M. B. (1998). Immunocytochemical colocalization of specific immunoglobulin A with sendai virus protein in infected polarized epithelium. J. Exp. Med. 188:1223–1229.
Fukushima, Y., Kawata, Y., Hara, H., Terada, A., and Mitsuoka, T. (1998). Effect of a probiotic formula on intestinal immunoglobulin A production in healthy children. Int. J. Food Microbiol. 42:39–44.
Geissmann, F., Launay, P., Pasquier, B., Lepelletier, Y., Leborgne, M., Lehuen, A., Brousse, N., and Monteiro, R. C. (2001). A subset of human dendritic cells expresses IgA Fc receptor (CD89), which mediates internalization and activation upon cross-linking by IgA complexes. J. Immunol. 166:346–352.
Giugliano, L. G., Ribeiro, S. T., Vainstein, M. H., and Ulhoa, C. J. (1995). Free secretory component and lactoferrin of human milk inhibit the adhesion of enterotoxigenic Escherichia coli. J. Med. Microbiol. 42:3–9.
Gonnella, P. A., Chen, Y., Inobe, J., Komagata, Y., Quartulli, M., and Weiner, H. L. (1998). In situ immune response in gut-associated lymphoid tissue (GALT) following oral antigen in TCR-transgenic mice. J. Immunol. 160:4708–4718.
Hammerschmidt, S., Talay, S. R., Brandtzaeg, P., and Chhatwal, G. S. (1997). SpsA, a novel pneumococcal surface protein with specific binding to secretory immunoglobulin A and secretory component. Mol. Microbiol. 25:1113–1124.
Hammerschmidt, S., Tillig, M. P., Wolff, S., Vaerman, J. P., and Chhatwal, G. S. (2000). Species-specific binding of human secretory component to SpsA protein of Streptococcus pneumoniae via a hexapeptide motif. Mol. Microbiol. 36:726–736.
Heystek, H. C., Moulon, C., Woltman, A. M., Garonne, P., and van Kooten, C. (2002). Human immature dendritic cells efficiently bind and take up secretory IgA without the induction of maturation. J. Immunol. 168:102–107.
Hooper, L. V., and Gordon, J. I. (2001). Commensal host-bacterial relationships in the gut. Science 292:1115–1118.
Huang, Y. T., Wright, A., Gao, X., Kulick, L., Yan, H., and Lamm, M. E. (2005). Intraepithelial cell neutralization of HIV-1 replication by IgA. J. Immunol. 174:4828–4835.
Iwasaki, A., and Kelsall, B. L. (1999). Freshly isolated Peyer’s patch, but not spleen, dendritic cells produce interleukin 10 and induce the differentiation of T helper type 2 cells. J. Exp. Med. 190:229–239.
Jang, M. H., Kweon, M. N., Iwatani, K., Yamamoto, M., Terahara, K., Sasakawa, C., Suzuki, T., Nochi, T., Yokota, Y., Rennert, P. D., Hiroi, T., Tamagawa, H., Iijima, H., Kunisawa, J., Yuki, Y., and Kiyono, H. (2004). Intestinal villous M cells: An antigen entry site in the mucosal epithelium. Proc. Natl. Acad. Sci. USA 101:6110–6115.
Jenkins, S. L., Wang, J., Vazir, M., Vela, J., Sahagun, O., Gabbay, P., Hoang, L., Diaz, R. L., Aranda, R., and Martin, M. G. (2003). Role of passive and adaptive immunity in influencing enterocyte-specific gene expression. Am. J. Physiol:. Gastrointest. Liver Physiol. 285:G714–G725.
Kaetzel, C. S. (2001). Polymeric Ig receptor: defender of the fort or Trojan horse? Curr. Biol. 11:R35–R38.
Kaetzel, C. S., Robinson, J. K., Chintalacharuvu, K. R., Vaerman, J. P., and Lamm, M. E. (1991). The polymeric immunoglobulin receptor (secretory component) mediates transport of immune complexes across epithelial cells: a local defense function for IgA. Proc. Natl. Acad. Sci. USA 88:8796–8800.
Kerr, M. A. (1990). The structure and function of human IgA. Biochem. J. 271:285–296.
Kiyono, H., McGhee, J. R., Mosteller, L. M., Eldridge, J. H., Koopman, W. J., Kearney, J. F., and Michalek, S. M. (1982). Murine Peyer’s patch T cell clones. Characterization of antigen-specific helper T cells for immunoglobulin A responses. J. Exp. Med. 156:1115–1130.
Lamm, M. E. (1997). Interaction of antigens and antibodies at mucosal surfaces. Annu. Rev. Microbiol. 51:311–340.
Langley, R., Wines, B., Willoughby, N., Basu, I., Proft, T., and Fraser, J. D. (2005). The staphylococcal superantigen-like protein 7 binds IgA and complement C5 and inhibits IgA-Fc alpha RI binding and serum killing of bacteria. J. Immunol. 174:2926–2933.
Liepke, C., Adermann, K., Raida, M., Magert, H. J., Forssmann, W. G., and Zucht, H. D. (2002). Human milk provides peptides highly stimulating the growth of bifidobacteria. Eur. J. Biochem. 269:712–718.
Lindh, E. (2005). Increased resistance of immunoglobulin A dimers to proteolytic degradation after binding of secretory component. J. Immunol. 114:284–286.
Lorenz, R. G., and Newberry, R. D. (2004). Isolated lymphoid follicles can function as sites for induction of mucosal immune responses. Ann. NY Acad Sci. 1029:44–57.
Lu, L., Lamm, M. E., Li, H., Corthésy, B., and Zhang, J. R. (2003). The human polymeric immunoglobulin receptor binds to Streptococcus pneumoniae via domains 3 and 4. J. Biol. Chem. 278:48, 178–48, 187.
Luo, R., Mann, B., Lewis, W. S., Rowe, A., Heath, R., Stewart, M. L., Hamburger, A. E., Sivakolundu, S., Lacy, E. R., Bjorkman, P. J., Tuomanen, E., and Kriwacki, R. W. (2005). Solution structure of choline binding protein A, the major adhesin of Streptococcus pneumoniae. EMBO J. 24:34–43.
Macpherson, A. J., Gatto, D., Sainsbury, E., Harriman, G. R., Hengartner, H., and Zinkernagel, R. M. (2000). A primitive T cell-independent mechanism of intestinal mucosal IgA responses to commensal bacteria. Science 288:2222–2226.
Macpherson, A. J., Hunziker, L., McCoy, K., and Lamarre, A. (2001). IgA responses in the intestinal mucosa against pathogenic and non-pathogenic microorganisms. Microbes Infect. 3:1021–1035.
Macpherson, A. J., and Uhr, T. (2004). Induction of protective IgA by intestinal dendritic cells carrying commensal bacteria. Science 303:1662–1665.
Mantis, N. J., Cheung, M. C., Chintalacharuvu, K. R., Rey, J., Corthésy, B., and Neutra, M. R. (2002). Selective adherence of IgA to murine Peyer’s patch M cells: evidence for a novel IgA receptor. J. Immunol. 169:1844–1851.
Mantis, N. J., Farrant, S. A., and Mehta, S. (2004). Oligosaccharide side chains on human secretory IgA serve as receptors for ricin. J. Immunol. 172:6838–6845.
Marshall, L. J., Perks, B., Ferkol, T., and Shute, J. K. (2001). IL-8 released constitutively by primary bronchial epithelial cells in culture forms an inactive complex with secretory component. J. Immunol. 167:2816–2823.
Mattu, T. S., Pleass, R. J., Willis, A. C., Kilian, M., Wormald, M. R., Lellouch, A. C., Rudd, P. M., Woof, J. M., and Dwek, R. A. (1998). The glycosylation and structure of human serum IgA1, Fab, and Fc regions and the role of N-glycosylation on Fc alpha receptor interactions. J. Biol. Chem. 273:2260–2272.
Mazanec, M. B., Kaetzel, C. S., Lamm, M. E., Fletcher, D., and Nedrud, J. G. (1992). Intracellular neutralization of virus by immunoglobulin A antibodies. Proc. Natl. Acad. Sci. USA 89:6901–6905.
Mazmanian, S. K., Liu, C. H., Tzianabos, A. O., and Kasper, D. L. (2005). An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system. Cell 122:107–118.
Mellman, I., and Steinman, R. M. (2001). Dendritic cells: specialized and regulated antigen processing machines. Cell 106:255–258.
Mestecky, J., Russell, M. W., and Elson, C. O. (1999). Intestinal IgA: Novel views on its function in the defence of the largest mucosal surface. Gut 44:2–5.
Mostov, K. E., Kraehenbuhl, J. P., and Blobel, G. (1980). Receptor-mediated transcellular transport of immunoglobulin: synthesis of secretory component as multiple and larger transmembrane forms. Proc. Natl. Acad. Sci. USA 77:7257–7261.
Newburg, D. S. (1999). Human milk glycoconjugates that inhibit pathogens. Curr. Med. Chem. 6:117–127.
Niess, J. H., Brand, S., Gu, X., Landsman, L., Jung, S., McCormick, B. A., Vyas, J. M., Boes, M., Ploegh, H. L., Fox, J. G., Littman, D. R., and Reinecker, H. C. (2005). CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance. Science 307:254–258.
Owen, R. L. (1999). Uptake and transport of intestinal macromolecules and microorganisms by M cells in Peyer’s patches: A personal and historical perspective. Semin. Immunol. 11:157–163.
Palestrant, D., Holzknecht, Z. E., Collins, B. H., Parker, W., Miller, S. E., and Bollinger, R. R. (2004). Microbial biofilms in the gut: visualization by electron microscopy and by acridine orange staining. Ultrastruct. Pathol. 28:23–27.
Pasquier, B., Launay, P., Kanamaru, Y., Moura, I. C., Pfirsch, S., Ruffie, C., Henin, D., Benhamou, M., Pretolani, M., Blank, U., and Monteiro, R. C. (2005). Identification of FcalphaRI as an inhibitory receptor that controls inflammation: dual role of FcRgamma ITAM. Immunity 22:31–42.
Perrier, C., Sprenger, N., and Corthésy, B. (2006). Glycans on secretory component participate in innate protection against mucosal pathogens. J. Biol. Chem. 281:14, 280–14, 287.
Phalipon, A., Cardona, A., Kraehenbuhl, J. P., Edelman, L., Sansonetti, P. J., and Corthésy, B. (2002). Secretory component: a new role in secretory IgA-mediated immune exclusion in vivo. Immunity 17:107–115.
Phalipon, A., and Corthésy, B. (2003). Novel functions of the polymeric Ig receptor: well beyond transport of immunoglobulins. Trends Immunol. 24:55–58.
Poger, M. E., and Lamm, M. E. (1974). Localization of free and bound secretory component in human intestinal epithelial cells. A model for the assembly of secretory IgA. J. Exp. Med. 139:629–642.
Rescigno, M., Urbano, M., Valzasina, B., Francolini, M., Rotta, G., Bonasio, R., Granucci, F., Kraehenbuhl, J. P., and Ricciardi-Castagnoli, P. (2001). Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria. Nat. Immunol. 2:361–367.
Rey, J., Garin, N., Spertini, F., and Corthésy, B. (2004). Targeting of secretory IgA to Peyer’s patch dendritic and T cells after transport by intestinal M cells. J. Immunol. 172:3026–3033.
Rhee, K. J., Sethupathi, P., Driks, A., Lanning, D. K., and Knight, K. L. (2004). Role of commensal bacteria in development of gut-associated lymphoid tissues and preimmune antibody repertoire. J. Immunol. 172:1118–1124.
Rimoldi, M., Chieppa, M., Salucci, V., Avogadri, F., Sonzogni, A., Sampietro, G. M., Nespoli, A., Viale, G., Allavena, P., and Rescigno, M. (2005). Intestinal immune homeostasis is regulated by the crosstalk between epithelial cells and dendritic cells. Nat. Immunol. 6:507–514.
Robinson, J. K., Blanchard, T. G., Levine, A. D., Emancipator, S. N., and Lamm, M. E. (2001). A mucosal IgA-mediated excretory immune system in vivo. J. Immunol. 166:3688–3692.
Rosenow, C., Ryan, P., Weiser, J. N., Johnson, S., Fontan, P., Ortqvist, A., and Masure, H. R. (1997). Contribution of novel choline-binding proteins to adherence, colonization and immunogenicity of Streptococcus pneumoniae. Mol. Microbiol. 25:819–829.
Roy, M. J., and Varvayanis, M. (1987). Development of dome epithelium in gut-associated lymphoid tissues: association of IgA with M cells. Cell Tissue Res. 248:645–651.
Royle, L., Roos, A., Harvey, D. J., Wormald, M. R., van Gijlswijk-Janssen, D., el-Redwan, R. M., Wilson, I. A., Daha, M. R., Dwek, R. A., and Rudd, P. M. (2003). Secretory IgA N- and O-glycans provide a link between the innate and adaptive immune systems. J. Biol. Chem. 278:20, 140–20, 153.
Rudd, P. M., Elliott, T., Cresswell, P., Wilson, I. A., and Dwek, R. A. (2001). Glycosylation and the immune system. Science 291:2370–2376.
Russell, M. W., Reinholdt, J., and Kilian, M. (1989). Anti-inflammatory activity of human IgA antibodies and their Fab alpha fragments: Inhibition of IgG-mediated complement activation. Eur. J. Immunol. 19:2243–2249.
Saltzman, W. M., Radomsky, M. L., Whaley, K. J., and Cone, R. A. (1994). Antibody diffusion in human cervical mucus. Biophys. J. 66:508–515.
Sandor, M., Waldschmidt, T. J., Williams, K. R., and Lynch, R. G. (1990). IgA-induced avidity maturation of IgA Fc receptors on murine T lymphocytes. J. Immunol. 144:4562–4570.
Schneeman, T. A., Bruno, M. E., Schjerven, H., Johansen, F. E., Chady, L., and Kaetzel, C. S. (2005). Regulation of the polymeric Ig receptor by signaling through TLRs 3 and 4: Linking innate and adaptive immune responses. J. Immunol. 175:376–384.
Schroten, H., Stapper, C., Plogmann, R., Kohler, H., Hacker, J., and Hanisch, F. G. (1998). Fab-independent antiadhesion effects of secretory immunoglobulin A on S-fimbriated Escherichia coli are mediated by sialyloligosaccharides. Infect. Immun. 66:3971–3973.
Shroff, K. E., Meslin, K., and Cebra, J. J. (1995). Commensal enteric bacteria engender a self-limiting humoral mucosal immune response while permanently colonizing the gut. Infect. Immun. 63:3904–3913.
Stoel, M., Jiang, H. Q., van Diemen, C. C., Bun, J. C., Dammers, P. M., Thurnheer, M. C., Kroese, F. G., Cebra, J. J., and Bos, N. A. (2005). Restricted IgA repertoire in both B-1 and B-2 cell-derived gut plasmablasts. J. Immunol. 174:1046–1054.
Suzuki, K., Meek, B., Doi, Y., Muramatsu, M., Chiba, T., Honjo, T., and Fagarasan, S. (2004). Aberrant expansion of segmented filamentous bacteria in IgA-deficient gut. Proc. Natl. Acad. Sci. USA 101:1981–1986.
Suzuki, K., Oida, T., Hamada, H., Hitotsumatsu, O., Watanabe, M., Hibi, T., Yamamoto, H., Kubota, E., Kaminogawa, S., and Ishikawa, H. (2000). Gut cryptopatches: direct evidence of extrathymic anatomical sites for intestinal T lymphopoiesis. Immunity 13:691–702.
Tejada-Simon, M. V., Lee, J., Ustunol, Z., and Pestka, J. J. (1999). Ingestion of yogurt containing Lactobacillus acidophilus and Bifidobacterium to potentiate immunoglobulin A responses to cholera toxin in mice. J. Dairy Sci. 82:649–660.
Umesaki, Y., and Setoyama, H. (2000). Structure of the intestinal flora responsible for development of the gut immune system in a rodent model. Microbes Infect. 2:1343–1351.
Underdown, B. J., DeRose, J., Koczekan, K., Socken, D., and Weicker, J. (1977). Isolation of human secretory component by affinity chromatography on IgM-sepharose. Immunochemistry 14:111–118.
van der Waaij, L. A., Limburg, P. C., Mesander, G., and van der Waaij, D. (1996). In vivo IgA coating of anaerobic bacteria in human faeces. Gut 38:348–354.
Weltzin, R., Lucia-Jandris, P., Michetti, P., Fields, B. N., Kraehenbuhl, J. P., and Neutra, M. R. (1989). Binding and transepithelial transport of immunoglobulins by intestinal M cells: Demonstration using monoclonal IgA antibodies against enteric viral proteins. J. Cell. Biol. 108:1673–1685.
Williamson, E., Bilsborough, J. M., and Viney, J. L. (2002). Regulation of mucosal dendritic cell function by receptor activator of NF-kappa B (RANK)/RANK ligand interactions: impact on tolerance induction. J. Immunol. 169:3606–3612.
Wold, A. E., Mestecky, J., Tomana, M., Kobata, A., Ohbayashi, H., Endo, T., and Eden, C. S. (1990). Secretory immunoglobulin A carries oligosaccharide receptors for Escherichia coli type 1 fimbrial lectin. Infect. Immun. 58:3073–3077.
Wu, H. Y., and Weiner, H. L. (2003). Oral tolerance. Immunol. Res. 28:265–284.
Yoshida, M., Claypool, S. M., Wagner, J. S., Mizoguchi, E., Mizoguchi, A., Roopenian, D. C., Lencer, W. I., and Blumberg, R. S. (2004). Human neonatal Fc receptor mediates transport of IgG into luminal secretions for delivery of antigens to mucosal dendritic cells. Immunity 20:769–783.
Zhang, J. R., Mostov, K. E., Lamm, M. E., Nanno, M., Shimida, S., Ohwaki, M., and Tuomanen, E. (2000). The polymeric immunoglobulin receptor translocates pneumococci across human nasopharyngeal epithelial cells. Cell 102:827–837.
Zhou, F, Kraehenbuhl, J. P., and Neutra, M. R. (1995). Mucosal IgA response to rectally administered antigen formulated in IgA-coated liposomes. Vaccine 13:637–644.
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Phalipon, A., Corthésy, B. (2007). Novel Functions for Mucosal SIgA. In: Kaetzel, C.S. (eds) Mucosal Immune Defense: Immunoglobulin A. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-72232-0_8
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