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Protective Immunity Against Plague

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The Genus Yersinia

Part of the book series: Advances In Experimental Medicine And Biology ((AEMB,volume 603))

Plague, an infectious disease that reached catastrophic proportions during three pandemics, continues to be a legitimate public health concern worldwide. Although antibiotic therapy for the causative agent Yersinia pestis is available, pharmaceutical supply limitations, multi-drug resistance from natural selection as well as malicious bioengineering are a reality. Consequently, plague vaccinology is a priority for biodefense research. Development of a multi-subunit vaccine with Fraction 1 and LcrV as protective antigens seems to be receiving the most attention. However, LcrV has been shown to cause immune suppression and Y. pestis mutants lacking F1 expression are thought to be fully virulent in nature and in animal experiments. The LcrV variant, rV10, retains the well documented protective antigenic properties of LcrV but with diminished inhibitory effects on the immune system. More research is required to examine the molecular mechanisms of vaccine protection afforded by surface protein antigens and to decipher the host mechanisms responsible for vaccine success.

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Authors and Affiliations

  1. Department of Microbiology, University of Chicago, Chicago, IL, USA

    Claire Cornelius, Olaf Schneewind, Deborah Anderson & Lauriane Quenee

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  1. Claire Cornelius
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  2. Olaf Schneewind
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  1. University of Kentucky, 800 Rose Street, 40536, Lexington, KY, USA

    Robert D. Perry  & Jacqueline D. Fetherston  & 

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Cornelius, C., Schneewind, O., Anderson, D., Quenee, L. (2007). Protective Immunity Against Plague. In: Perry, R.D., Fetherston, J.D. (eds) The Genus Yersinia. Advances In Experimental Medicine And Biology, vol 603. Springer, New York, NY. https://doi.org/10.1007/978-0-387-72124-8_38

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