Yersinia enterocolitica biovar 1B maintains two distinct and independently operating type 3 secretion (T3S) systems with the capacity to translocate toxic effector proteins into mammalian cells. Each of these T3S systems plays a role in the outcome of an infection by influencing different stages of infection. Recent investigations of the Ysa T3S system have revealed it is important for Y. enterocolitica survival during the gastrointestinal phase of infection. This sets this system apart from the Ysc T3S system which is important for systemic infections. Identification of the effector proteins has provided insight on how the Ysa T3S system modulates Y. enterocolitica interactions with the host. In part, the Ysa T3S system targets the innate immune response to suppress the ability of the host to rapidly clear an infection.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Aepfelbacher, M. (2004) Modulation of Rho GTPases by type III secretion system translo-cated effectors of Yersinia. Rev. Physiol. Biochem. Pharmacol. 152, 65-77.
Bliska, J.B., Guan, K.L., Dixon, J.E. and Falkow, S. (1991) Tyrosine phosphate hydrolysis of host proteins by an essential Yersinia virulence determinant. PNAS 88, 1187-1191.
Botsford, J.L. and Harman, J.G. (1992) Cyclic AMP in prokaryotes. Microbiol. Rev. 56, 100-122.
Bottone, E.J. (1999) Yersinia enterocolitica: overview and epidemiologic correlates. Microbes Infect. 1, 323-333.
Bradford, W.D., Noce, P.S. and Gutman, L.T. (1974) Pathologic features of enteric infection with Yersinia enterocolitica. Arch. Pathol. 98, 17-22.
Buttner, D. and Bonas, U. (2002) Port of entry--the type III secretion translocon. Trends Mi-crobiol. 10, 186-192.
Carniel, E. and Mollaret, H.H. (1990) Yersiniosis. Comp. Immunol. Microbiol. Infect. Dis. 13, 51-58.
Carter, P.B. (1975a) Oral Yersinia enterocolitica infection of mice. Amer. J. Pathol. 81, 703-705.
Carter, P.B. (1975b) Pathogenicity of Yersinia enterocolitica for mice. Infect. Immun. 11, 164-170.
Carter, P.B. and Collins, F.M. (1974a) Experimental Yersinia enterocolitica infection in mice: kinetics of growth. Infect. Immun. 9, 851-857.
Carter, P.B. and Collins, F.M. (1974b) The route of enteric infection in normal mice. J. Exp. Med. 139, 1189-1203.
Castanie-Cornet, M.P., Treffandier, H., Francez-Charlot, A., Gutierrez, C. and Cam, K. (2007) The glutamate-dependent acid resistance system in Escherichia coli: essential and dual role of the His-Asp phosphorelay RcsCDB/AF. Microbiology 153, 238-246.
Cornelis, G., Laroche, Y., Balligand, G., Sory, M.-P. and Wauters, G. (1987) Y. enterocolitica, a primary model for bacterial invasiveness. Rev. Infect. Dis. 9, 64-87.
Cover, T.L. and Aber, R.C. (1989) Yersinia enterocolitica. N. Engl. J. Med. 321, 16-24.
Denecker, G., Totemeyer, S., Mota, L.J., Troisfontaines, P., Lambermont, I., Youta, C., Stainier, I., Ackermann, M. and Cornelis, G.R. (2002) Effect of low- and high-virulence Yersinia enterocolitica strains on the inflammatory response of human umbilical vein en-dothelial cells. Infect. Immun. 70, 3510-20.
Erickson, K.D. and Detweiler, C.S. (2006) The Rcs phosphorelay system is specific to enteric pathogens/commensals and activates ydeI, a gene important for persistent Salmonella infection of mice. Mol. Microbiol. 62, 883-894.
Foultier, B., Troisfontaines, P., Muller, S., Opperdoes, F.R. and Cornelis, G.R. (2002) Charac-terization of the ysa pathogenicity locus in the chromosome of Yersinia enterocolitica and phylogeny analysis of Type III secretion systems. J. Mol. Evol. 55, 37-51.
Foultier, B., Troisfontaines, P., Vertommen, D., Marenne, M.-N., Rider, M., Persot, C. and Cornelis, G.R. (2003) Identification of substrates and chaperone from the Yersinia entero-colitica 1B Ysa type III secretion system. Infect. Immun. 71, 242-253.
Galan, J.E. and Wolf-Watz, H. (2006) Protein delivery into eukaryotic cells by type III secre-tion machines. Nature 444, 567-573.
Gleason, T.H. and Patterson, S.D. (1982) The pathology of Yersinia enterocolitica ileocolitis. Amer. J. Sur. Pathol. 6, 347-355.
Haller, J.C., Carlson, S., Pederson, K.J. and Pierson, D.E. (2000) A chromosomally encoded type III secretion pathway in Yersinia enterocolitica is important in virulence. Mol. Mi-crobiol. 36, 1436-1446.
Hanski, C., Kutschka, U., Schmoranzer, H.P., Naumann, M., Stallmach, A., Hahn, H., Menge, H. and Riecken, E.O. (1989) Immunohistochemical and electron microscopic study of interaction of Yersinia enterocolitica serotype O:8 with intestinal mucosa during experimental enteritis. Infect. Immun. 57, 673-678.
Iwobi, A., Heesemann, J., Garcia, E., Igwe, E., Noelting, C. and Rakin, A. (2003) Novel viru-lence-associated type II secretion system unique to high-pathogenicity Yersinia enterocoli-tica. Infect. Immun. 71, 1872-1879.
Kim, D.W., Lenzen, G., Page, A.-L., Legrain, P. and Sansonetti, P.J. (2005) The Shigella flexneri effector OspG interferes with innate immune responses by targeting ubiquitin-conjugating enzymes. PNAS 102, 14046-14051.
Marenne, M.-N., Mota, L.J. and Cornelis, G.R. (2004) The pYV plasmid and the Ysc-Yop type III secretion system. In: E. Carniel and B.J. Hinebusch (Eds.), Yersinia: Molecular and Cellular Biology. Horizon Press, Norfolk, pp. 319-348.
Marlovits, T.C., Kubori, T., Lara-Tejero, M., Thomas, D., Unger, V.M. and Galan, J.E. (2006) Assembly of the inner rod determines needle length in the type III secretion injectisome. Nature 441, 637-40.
Matsumoto, H. and Young, G.M. (2006) Proteomic and functional analysis of the suite of Ysp proteins exported by the Ysa type III secretion system of Yersinia enterocolitica Biovar 1B. Mol. Microbiol. 59, 689-706.
Mukherjee, S., Keitany, G., Li, Y., Wang, Y., Ball, H.L., Goldsmith, E.J. and Orth, K. (2006) Yersinia YopJ acetylates and inhibits kinase activation by blocking phosphorylation. Science 312, 1211-1214.
Petersen, S. and Young, G.M. (2002) Essential role for cAMP and its receptor protein in Yersinia enterocolitica virulence. Infect. Immun. 70, 3665-3672.
Portnoy, D.A., Wolf-Watz, H., Bolin, I., Beeder, A.B. and Falkow, S. (1984) Characterization of common virulence plasmids in Yersinia species and their role in the expression of outer membrane proteins. Infect. Imunn. 43, 108-114.
Snellings, N.J., Popek, M. and Linder, L.E. (2001) Complete DNA sequence of Yersinia enterocolitica Serotype O:8 low-calcium response plasmid reveals a new virulence plas-mid-associated replicon. Infect. Immun. 69, 4627-4638.
Sory, M.-P. and Cornelis, G.R. (1994) Translocation of hybrid YopE-adenylate cyclase from Yersinia enterocolitica into HeLa cells. Mol. Microbiol. 14, 583-594.
Sory, M.-P., Boland, A., Lambermont, I., Cornelis, G.R. (1995) Identification of the YopE and YopH domains required for secretion and internalization into the cytosol of macrophages, using the cyaA gene fusion approach. PNAS 92, 11928-12002.
Tamano, K., Katayama, E., Toyotome, T., Sasakawa, C. (2002) Shigella Spa32 is an essential secretory protein for functional type III secretion machinery and uniformity of its needle length. J. Bacteriol. 184, 1244-1252.
Thomson, N.R., Howard, S., Wren, B.W., Holden, M.T., Crossman, L., Challis, G.L., Churcher, C., Mungall, K., Brooks, K., Chillingworth, T., Feltwell, T., Abdellah, Z., Hauser, H., Jagels, K., Maddison, M., Moule, S., Sanders, M., Whitehead, S., Quail, M.A., Dougan, G., Parkhill, J. and Prentice, M.B. (2006) The complete genome sequence and comparative genome analysis of the high pathogenicity Yersinia enterocolitica strain 8081. PLoS Genet 2, e206.
Vantrappen, G., Ponette, E., Geboes, K. and Bertrand, P. (1977) Yersinia enteritis and entero-colitis: gastroenterological aspects. Gastroenterol. 72, 220-227.
Venecia, K. and Young, G.M. (2005) Environmental regulation and virulence attributes of the Yas type III secretion system of Yersinia entercolitica Biovar 1B. Infect. Immun. 73, 5961-5977.
Viboud, G.I. and Bliska, J.B. (2005) Yersinia outer proteins: role in modulation of host cell signaling responses and pathogenesis. Annu. Rev. Microbiol. 59, 69-89.
Walker, K.A. and Miller, V.L. (2004) Regulation of the Ysa type III secretion system of Yersinia enterocolitica by YsaE/SycB and YsrS/YsrR. J. Bacteriol. 186, 4056-4066.
Young, B.M. and Young, G.M. (2002a) Evidence for targeting of Yop effectors by the chro-mosomally encoded Ysa type III secretion system of Yersinia enterocolitica. J. Bacteriol. 184, 5563-5571.
Young, B.M. and Young, G.M. (2002b) YplA is exported by the Ysc, Ysa and flagellar type III secretion systems of Yersinia enterocolitica. J. Bacteriol. 184, 1324-1334.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2007 Springer Science+Business Media, LLC
About this chapter
Cite this chapter
Young, G.M. (2007). The Ysa Type 3 Secretion System of Yersinia enterocolitica Biovar 1B. In: Perry, R.D., Fetherston, J.D. (eds) The Genus Yersinia. Advances In Experimental Medicine And Biology, vol 603. Springer, New York, NY. https://doi.org/10.1007/978-0-387-72124-8_26
Download citation
DOI: https://doi.org/10.1007/978-0-387-72124-8_26
Publisher Name: Springer, New York, NY
Print ISBN: 978-0-387-72123-1
Online ISBN: 978-0-387-72124-8
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)